Connecting inside out: Development of the social brain in infants and toddlers with a focus on myelination as a marker of brain maturation

Early childhood is a sensitive period for learning and social skill development. The maturation of cerebral regions underlying social processing lays the foundation for later social-emotional competence. This study explored myelin changes in social brain regions and their association with changes in parent-rated social-emotional development in a cohort of 129 children (64 females, 0–36 months, 77 White). Results reveal a steep increase in myelination throughout the social brain in the first 3 years of life that is significantly associated with social-emotional development scores. These findings add knowledge to the emerging picture of social brain development by describing neural underpinnings of human social behavior. They can contribute to identifying age-/stage-appropriate early life factors in this developmental domain.     

在线健康社区用户个人健康信息管理行为特征研究

[目的/意义] 旨在对在线健康社区用户的个人健康信息管理行为特征进行分析，并在此基础上，对"平台-PHIM-健康目标"这一模式中的元素之间的关系进行探讨。[方法/过程] 选择患有红斑狼疮的在线健康社区用户作为调查对象。采用聚类方法对个人健康信息管理行为的总体测度水平不同的群体进行识别；利用单因素方差分析（One-way ANOVA）对不同群组进行比较研究。[结果/结论] 将依托在线健康社区进行的个人健康信息管理行为界定为健康信息发现、健康信息互动和健康信息分享。从数据分析结果来看，首先，在线健康社区的红斑狼疮患者在个人健康信息管理行为水平上存在显著的高低差异。第二，用户所感知到的社会支持与其个人健康信息管理水平存在正相关关系。第三，个人健康信息管理与用户健康目标之间存在正相关关系。本研究为在线健康社区完善其服务方式，促进慢性病人个人健康信息管理水平提高提供合理建议。     

Does modality matter? A latent profile and transition analysis of sedentary behaviours among school-aged youth: The UP&DOWN study

ABSTRACT

The aims of this study were to identify profiles of sedentary behaviour (SB) patterns, based on leisure-time self-reported SB modalities (screen, educative, social, and relaxing) and to evaluate changes in these profiles over 2 years among Spanish youth aged 8–18 years. Latent profile analysis (LPA), a data-driven analytic approach, was used to identify groups of boys and girls (n = 1553; 48% girls; mean±SD age: 12.56 ± 2.49 y) with distinct SB profiles using the SB modalities (time/d) as input variables. Latent transition analysis, an extension of LPA that uses longitudinal data, was used to analyse 2-year changes in these profiles. At baseline, four and three SB profiles were found among boys (labelled: screen, educative, social, and relaxing) and girls (labelled: screen/social, educative, and relaxing), respectively. Overall, more girls (range: 48%-67%) had the same profile over time, than boys (40%-52%). Participants with a screen or relaxing SB profile at baseline were more likely to have an educative profile after 2 years. Youth with a social and an educative SB profile at baseline were more likely to transition to profiles characterized by higher screen and social SB, respectively. Using a novel and person-centered approach, this study identified gender-specific SB profiles that were moderately stable over time.     

Digital Module 16: Longitudinal Data Analysis

In this digital ITEMS module, Dr. Jeffrey Harring and Ms. Tessa Johnson introduce the linear mixed effects (LME) model as a flexible general framework for simultaneously modeling continuous repeated measures data with a scientifically defensible function that adequately summarizes both individual change as well as the average response. The module begins with a nontechnical overview of longitudinal data analyses drawing distinctions with cross-sectional analyses in terms of research questions to be addressed. Nuances of longitudinal designs, timing of measurements, and the real possibility of missing data are then discussed. The three interconnected components of the LME model—(1) a model for individual and mean response profiles, (2) a model to characterize the covariation among the time-specific residuals, and (3) a set of models that summarize the extent that individual coefficients vary—are discussed in the context of the set of activities comprising an analysis. Finally, they demonstrate how to estimate the linear mixed effects model within an open-source environment (R). The digital module contains sample R code, diagnostic quiz questions, hands-on activities in R, curated resources, and a glossary.     

被子植物精细胞分离和特性研究进展

精细胞分离是研究雄性生殖发育的前提之一,近半个世纪以来,人们运用不断更新的生物实验技术,对被子植物精细胞开展了分离及细胞分子特征的研究。分析被子植物精细胞分离方法,总结精细胞二型性与倾向性、细胞融合方面的研究成果,并对其研究意义和前景进行讨论。     

注重思想方法培养创造能力--浅谈《温度计》一节的教学

物理教学上世纪前50年重点是知识的教学,传授几百年来人们已发现的自然界的物理规律,了解自然现象。50～60年代开始转向知识间的联系,70～80年代开始注重知识的综合,本世纪更要重视思想方法的综合,而思想方法的必须在物理教学过程中注重物理思想、物理方法的教学,重视知识的探索过程,注重物理问题的发现以及探索解决问题的途径。现就《温度计》这一节谈谈我在教学中的实践。     

校园网管理信息系统中ASP技术应用

校园网络系统在学校的教学和管理工作中发挥着越来越重要的作用,本文从当前Internet/Intranet及MIS系统的发展出发,在比较当前流行的数据存取及信息处理技术基础上,阐述TASP的作用与优点及其在校园网信息处理中的应用。     

基于网络视频的设备远程维修与培训

现代设备复杂系数的不断提高,导致对设备维修技术专家的需求日益增大。基于网络视频的设备远程维修系统的出现,为缓解设备维修技术力量短缺的矛盾提供了新的解决方式。     

我国社区体育的发展现状及对策

采用文献资料法、访问座谈、比较研究等方法 ,对我国社区体育现状进行分析。结果显示 ,我国社区体育发展较落后 ,分布很不平衡。并对分析结果进行论述 ,提出有利社区体育发展的对策。