A fluorescence based method for the quantification of surface functional groups in closed micro- and nanofluidic channels

Surface analysis is critical for the validation of microfluidic surface modifications for biology, chemistry, and physics applications. However, until now quantitative analytical methods have mostly been focused on open surfaces. Here, we present a new fluorescence imaging method to directly measure the surface coverage of functional groups inside assembled microchannels over a wide dynamic range. A key advance of our work is the elimination of self-quenching to obtain a linear signal even with a high density of functional groups. This method is applied to image the density and monitor the stability of vapor deposited silane layers in bonded silicon/glass micro- and nanochannels.     

对我国学生体质状况的灰色关联聚类分析

以灰色系统理论中的关联分析方法为基础,建立了基于关联度的聚类分析方法,对1995年全国汉族7～22岁男性学生的体质进行了聚类评价。结果表明:我国大学阶段各年龄组学生群体体质处于最优这一层次;高中阶段各年龄组学生群体体质处于最差层次;初中阶段各年龄组学生群体体质处于中等层次;小学阶段的各年龄组学生群体体质分属于优、中、劣之间。同时显示出,基于灰色关联度聚类的方法计算简捷,结果直观清晰,从而为群体体质的综合评价提供了一种新的量化方法。     

ZNF533、DOCK4和IMMP2L基因多态性与中国东北汉族孤独症的关联研究(英文)

研究目的:ZNF533、DOCK4和IMMP2L在大脑发育过程中起到非常重要的作用,是孤独症研究的候选基因。高加索人群的研究结果发现,ZNF533、DOCK4和IMMP2L基因的5个单核苷酸多态性(SNP)位点与孤独症高度相关。为了探讨上述位点是否与中国孤独症发生相关,我们开展了东北汉族孤独症的核心家系研究。创新要点:孤独症候选基因多态位点的研究结果通常很难得到重复。本研究首次在中国东北汉族人群中验证了与高加索人群孤独症密切相关的候选位点。这一结果对孤独症的研究具有重要指导意义。研究方法:利用SNaPshot的方法,检测了中国东北汉族370个核心家系中ZNF533(rs11885327、rs1964081)、DOCK4(rs2217262)和IMMP2L(rs12537269、rs1528039)的分布情况,利用传递不平衡检验(TDT)分析了这些多态位点与孤独症发生的相关性。重要结论:ZNF533和DOCK4基因多态性与中国北方汉族孤独症发生存在显著关联。     

String vibration dampers do not reduce racket frame vibration transfer to the forearm

In this study, we examined the effect of string vibration damping devices on reducing racket frame vibration transfer to the forearm. Twenty participants volunteered to hold a tennis racket stationary in a forehand and backhand stroking position while tennis balls were fired at 20 m x s(-1) towards two impact locations, the node of vibration and the dead spot. A three-way analysis of variance with repeated measures on damping condition, impact location and stroke condition was performed on the data. The resonant frequency of the hand-held racket was found to be approximately 120 Hz. No significant differences in amplitude of vibration at the resonant frequency were found for the wrist or the elbow when damped and non-damped impacts were compared. Impacts at the dead spot produced greater amplitudes of vibration (P < 0.01) but no interaction between impact location and string dampers was evident. The string dampers had no effect on the grip force used or the muscle electrical activity in the forearm after impact. In conclusion, we found that string dampers do not reduce the amount of racket frame vibration received at the forearm. We suggest that string dampers remain a popular accessory among tennis players because of their acoustic effects and psychological support rather than any mechanical advantage.     

Optofluidic planar reactors for photocatalytic water treatment using solar energy

Optofluidics may hold the key to greater success of photocatalytic water treatment. This is evidenced by our findings in this paper that the planar microfluidic reactor can overcome the limitations of mass transfer and photon transfer in the previous photocatalytic reactors and improve the photoreaction efficiency by more than 100 times. The microreactor has a planar chamber (5 cm×1.8 cm×100 μm) enclosed by two TiO(2)-coated glass slides as the top cover and bottom substrate and a microstructured UV-cured NOA81 layer as the sealant and flow input∕output. In experiment, the microreactor achieves 30% degradation of 3 ml 3×10(-5)M methylene blue within 5 min and shows a reaction rate constant two orders higher than the bulk reactor. Under optimized conditions, a reaction rate of 8% s(-1) is achieved under solar irradiation. The average apparent quantum efficiency is found to be only 0.25%, but the effective apparent quantum efficiency reaches as high as 25%. Optofluidic reactors inherit the merits of microfluidics, such as large surface∕volume ratio, easy flow control, and rapid fabrication and offer a promising prospect for large-volume photocatalytic water treatment.     

Discrete-time stochastic impulsive BAM neural networks with leakage and mixed time delays: An exponential stability problem

In this paper, the stability analysis of impulsive discrete-time stochastic BAM neural networks with leakage and mixed time delays is investigated via some novel Lyapunov–Krasoviskii functional terms and effective techniques. For the target model, stochastic disturbances are described by Brownian motion. Then the result is further extended to address the problem of robust stability of uncertain discrete-time BAM neural networks. The conditions obtained here are expressed in terms of Linear Matrix Inequalities (LMIs), which can be easily checked by MATLAB LMI control toolbox. Finally, few numerical examples are presented to substantiate the effectiveness of the derived LMI-based stability conditions.     

基于Proteus软件的单片机仿真实例

本文以AT89C51单片机显示汉字点阵系统为例,介绍了仿真软件Proteus的基本功能和特点,研究如何使用仿真软件进行仿真,以及和Keil软件联合仿真的方法,对学生学习Proteus仿真软件具有一定的指导意义,而且提高开发效率,降低开发成本,缩短开发周期。