CRP,but not TNF-α or IL-6, decreases after weight loss in patients with morbid obesity exposed to intensive weight reduction and balneological treatment

Objective

The aim of this study was to evaluate the concentrations of C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and the degree of homeostasis model assessment-insulin resistance (HOMA-IR) in patients with morbid obesity exposed to a three-week low-calorie diet and balneotherapy.

Methods

The study included 33 patients (25 females and 8 males; mean age 46 years) with body mass index (BMI) values of >40 kg/m². Evaluations of CRP, IL-6, TNF-α, lipid profile, HOMA-IR, and fasting glucose were carried out before (baseline data) and three weeks after the treatment. The control group consisted of 20 healthy volunteers (15 females and 5 males) with a mean age of 39 years and BMI values of ≤24.9 kg/m².

Results

In the blood of patients with morbid obesity we found significantly elevated levels of CRP, TNF-α, triglycerides, HOMA-IR and fasting glucose, but a decreased level of high density lipoprotein (HDL)-cholesterol, compared with the healthy individuals. The treatment resulted in about a 9.4% reduction in body weight from 122.5 to 111.0 kg and a significant decrease in the concentration of CRP, but no change in TNF-α or IL-6. HOMA-IR was significantly reduced.

Conclusion

The decrease in CRP level without changes in TNF-α or IL-6 concentrations after the low-calorie diet and balneological treatment, suggests that an essential amount of adipose tissue must be removed before proper adipocyte function is restored. The decrease in HOMA-IR indicates an improvement in insulin sensitivity, which is beneficial in obese patients.

     

Visually focusing on the far versus the near target during the putting stroke

Abstract

The purpose was to evaluate the traditional method, of visually focusing on the ball, in comparison to focusing on the hole, during the putting stroke. The study design consisted of a pretest, a 4-week practice period, and a posttest. Participants (n = 31, handicap: 18.7 ± 10.4) practised using only one of the two gaze techniques. Testing consisted of having all participants putt using both gaze techniques from both a 1.22 m and a 4 m distance. Five putts were executed for each gaze technique/putt length combination for a total of 20 putts in each testing session per participant. The kinematics of every putting stroke executed during testing (1240 strokes) were captured using a TOMI® system. There was a significant improvement in putting success for both groups following practice (P = 0.001). Practising while visually focusing on the hole, resulted in a statistically significant reduction in putter speed variability in comparison to practising while visually focusing on the ball (P = 0.017). Visually focusing on the hole did not meaningfully (nor statistically) affect the quality of impact as assessed by the variability in face angle, stroke path, and impact spot at the precise moment the putter head contacted the ball.     

Visually focusing on the far versus the near target during the putting stroke

The purpose was to evaluate the traditional method, of visually focusing on the ball, in comparison to focusing on the hole, during the putting stroke. The study design consisted of a pretest, a 4-week practice period, and a posttest. Participants (n = 31, handicap: 18.7 ± 10.4) practised using only one of the two gaze techniques. Testing consisted of having all participants putt using both gaze techniques from both a 1.22 m and a 4 m distance. Five putts were executed for each gaze technique/putt length combination for a total of 20 putts in each testing session per participant. The kinematics of every putting stroke executed during testing (1240 strokes) were captured using a TOMI? system. There was a significant improvement in putting success for both groups following practice (P = 0.001). Practising while visually focusing on the hole, resulted in a statistically significant reduction in putter speed variability in comparison to practising while visually focusing on the ball (P = 0.017). Visually focusing on the hole did not meaningfully (nor statistically) affect the quality of impact as assessed by the variability in face angle, stroke path, and impact spot at the precise moment the putter head contacted the ball.