Connecting inside out: Development of the social brain in infants and toddlers with a focus on myelination as a marker of brain maturation

Early childhood is a sensitive period for learning and social skill development. The maturation of cerebral regions underlying social processing lays the foundation for later social-emotional competence. This study explored myelin changes in social brain regions and their association with changes in parent-rated social-emotional development in a cohort of 129 children (64 females, 0–36 months, 77 White). Results reveal a steep increase in myelination throughout the social brain in the first 3 years of life that is significantly associated with social-emotional development scores. These findings add knowledge to the emerging picture of social brain development by describing neural underpinnings of human social behavior. They can contribute to identifying age-/stage-appropriate early life factors in this developmental domain.     

Research Training Needs of Scientist‐Practitioners: Implications for Counselor Education

Counselors (N = 911) reported the research skills needed for practice and subsequent research training needs. Findings indicate that counselors have a high need for research skills at work, but training needs differ significantly by counselor type. Recommendations include increasing emphasis on single‐case design, survey design, and widely available data analysis tools.     

A comparison of methods to determine bilateral asymmetries in vertical leg stiffness

Whilst the measurement and quantification of vertical leg stiffness (K_vert) asymmetry is of important practical relevance to athletic performance, literature investigating bilateral asymmetry in K_vert is limited. Moreover, how the type of task used to assess K_vert may affect the expression of asymmetry has not been properly determined. Twelve healthy males performed three types of performance tasks on a dual force plate system to determine K_vert asymmetries; the tasks were (a) bilateral hopping, (b) bilateral drop jumping and (c) unilateral drop jumping. Across all the three methods, K_vert was significantly different between compliant and stiff limbs (P < 0.001) with a significant interaction effect between limb and method (P = 0.005). Differences in K_vert between compliant and stiff limbs were ?5.3% (P < 0.001), ?21.8% (P = 0.007) and ?15.1% (P < 0.001) for the bilateral hopping, bilateral drop jumping and unilateral drop jumping methods, respectively. All the three methods were able to detect significant differences between compliant and stiff limbs, and could be used as a diagnostic tool to assess K_vert asymmetry. Drop jumping tasks detected larger K_vert asymmetries than hopping, suggesting that asymmetries may be expressed to a greater extent in acyclic, maximal performance tasks.     

Evaluation of adverse drug reaction formatting in drug information mobile phone applications

Objective:To evaluate the differences in presentation (formatting) of adverse drug reaction (ADR) information within drug monographs in commonly used drug information (DI) mobile device applications.Methods:A cross-sectional analysis of ADR formatting of twenty commonly prescribed oral medications within seven DI mobile applications was performed. Databases were assessed for ADR information, including presence of placebo comparisons, severity of ADR, onset of ADR, formatting of ADRs in percentile (quantitative) format or qualitative format, whether references were used to cite information, and whether ADRs are grouped by organ system. Data was collected by two study investigators and discrepancies were resolved via consensus.Results:The seven DI mobile applications varied significantly on every analyzed ADR variable with the exception of ADR onset, which was absent in all databases. Significant differences were found for variables known to impact clinical judgment such as placebo comparisons and qualitative versus quantitative formatting. Placebo comparisons were most common among monographs in Lexicomp (30%) but were absent among monographs within other applications. Quantitative information was commonly used in most databases but was absent in Epocrates. Qualitative formatting was present in all Epocrates and Micromedex applications but absent in the majority of other applications. Substantial variations were also found in severity and grouping information.Conclusion:Substantial variation in ADR formatting exists among the most common DI mobile applications. These differences may translate into alternative interpretations of medical information and thus impact clinical judgment. Health care librarians and clinicians should consider ADR formatting when choosing between DI applications.     

Understanding the track and field sprint start through a functional analysis of the external force features which contribute to higher levels of block phase performance

This study aimed to identify the continuous ground reaction force (GRF) features which contribute to higher levels of block phase performance. Twenty-three sprint-trained athletes completed starts from their preferred settings during which GRFs were recorded separately under each block. Continuous features of the magnitude and direction of the resultant GRF signals which explained 90% of the variation between the sprinters were identified. Each sprinter’s coefficient score for these continuous features was then input to a linear regression model to predict block phase performance (normalised external power). Four significant (p < 0.05) predictor features associated with GRF magnitude were identified; there were none associated with GRF direction. A feature associated with greater rear block GRF magnitudes from the onset of the push was the most important predictor (β = 1.185), followed by greater front block GRF magnitudes for the final three-quarters of the push (β = 0.791). Features which included a later rear block exit (β = 0.254) and greater front leg GRF magnitudes during the mid-push phase (β = 0.224) were also significant predictors. Sprint practitioners are encouraged, where possible, to consider the continuous magnitude of the GRFs produced throughout the block phase in addition to selected discrete values.