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Dilutionisonekindofcrystallizationsthatiswidelyusedintheproductionofpharmaceuticals ,especiallyantibi otics.Dilutionhasmanyadvantagessuchashigherthrough putsbypreparingveryconcentratedinitialsolutions,loweroperatingtemperatureforheat labilesubstancesandbetterpu rificationasthemotherliquorretainsundesiredimpurities[1] .Oneofthecharacteristicsofdilutionisthatthesolventcom positionvarysastheprocessproceeds.Thesolventcomposi tionhasinfluenceonnotonlythenucleationratebutalsotherelativegrowthrateofe… 相似文献
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