Carnosine in health and disease

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.     

Virtual and non‐virtual realities: the changing roles of libraries and librarians

What is the future for libraries and their librarians? In trying to give an answer to this pressing question we do not deal with utopian libraries of the next century, but with the library and the librarian of the next decade. The emphasis is on libraries within educational and research institutions, especially university libraries. We examine the changes confronting the library of the future and identify four key aspects of the library of the future. It will be (i) a gateway to information, whatever format this information comes in and wherever it is located; (ii) an expertise centre; (iii) a physical entity, not only in the sense of being a social meeting place and place of scholarly interaction, but also as a place where students and other users are provided with modern study facilities and adequate user support; and (iv) a collection centre of printed material. Such libraries can only take on an appropriate shape and will only survive if the institutions that librarians serve in meet the four criteria outlined above. We look at the demands that will be made on professional library knowledge and skills and the new job responsibilities and job attitudes required.     

Interdisciplinary scholarly collaboration in data-intensive,public-funded,international digital humanities project work

The information practices of collaborative interdisciplinary researchers, especially in distributed environments, remain understudied. Embracing the naturalistic paradigm, this qualitative case study relies upon semi-structured interviews, snowball sampling, and grounded analysis. Based on interviews with 53 participants from 11 Digging Into Data 3 (DID3, 2014-2016) projects, this study examines the working practices of scholars (library and information science professionals, humanists, and computer scientists) engaging in collaborative, international, data-intensive, publicly-funded interdisciplinary research. Benefits of such work include avoiding redundancy, exploding disciplinary silos, and more ambitious, larger-scale outputs. Challenges and lessons learned center on innovation, flexibility, and failure, translation, intermediaries, divisions of labor and delegation of responsibilities and tasks, conflict resolution, technology, outputs and publication, and timeframe, sustainability, and infrastructure.     

A Comparative Analysis of Graduate Employment Prospects in European Labour Markets: A Study of Graduate Recruitment in Four Countries

The aim of this paper is to provide a comparative analysis of higher education and the graduate labour markets in selected European countries (France, Germany, Spain and United Kingdom) in the context of the expectations of graduates and prospective employers, and respective recruitment and selection practices. Expectations of graduating students from a number of European collaborating universities are sought and analysed in order to find out about a match between the knowledge and skills of graduates and the needs of European employers. The study examines the process of graduate recruitment, employee and employer expectations, and the role of higher education institutions in meeting such expectations. Primary data was gathered from 252 employers and 485 final year (graduating) students through the use of questionnaires. The analysis of the data collected has revealed different approaches to but similar methods of graduate recruitment between the four countries. Despite the current differences in higher education systems and labour market trends, the expectations of employers and graduating students are more similar than different. It is concluded that EU graduates will have good employment prospects in an integrated labour market.     

Paving the Olympic Dream: The Politics of the 2007 Pan-American Games in Rio de Janeiro

Abstract

The making of the 2007 Pan-American Games, held in the city of Rio de Janeiro, marked the beginning of the long transformation that this city would undergo in connection to sports mega-events. This paper revisits how the 2007 Pan-American Games were largely produced under the promise that its legacies, particularly the infrastructural ones, could be effectively mobilized in order to strengthen the chances of bringing the Olympics to Brazil for the first time. Whereas this rhetoric has proven somewhat successful in helping the city to secure the right to host the 2016 Olympics, the alleged connection between both events has shown to be much more limited than its proponents had initially advertized. In reality, most of the venues constructed for the Pan-American Games had to be thoroughly renovated for the Olympics, while some of them presented structural problems and/or failed to meet the standards imposed by international sports federations.     

Power,Perceptions, and Relationships: A Model of Co-Teaching in Higher Education

Co-teaching has historically been used in K–12 education to provide students with disabilities access to general curriculum; therefore, much of the co-teaching literature has focused on the K–12 population. Research on collegiate co-teaching has been more limited and largely focused on the advantages and disadvantages of co-teaching, omitting important factors that affect relationships between partners. This qualitative study involved seven interviews of co-teachers of graduate and undergraduate classes in order to better understand interactions between college-level co-teaching dyads. Data analysis revealed themes of power and authority structures, dynamics of co-teaching relationships, and co-teachers' perceptions related to advantages of co-teaching, disadvantages of co-teaching, and student experiences. The researchers developed the Circular Model of Collegiate Co-Teaching, an original model to explain how these themes and subthemes are interrelated and affect each other. Specific best practices and new insights for collegiate co-teaching practice are discussed.     

Revisiting free school meal eligibility as a proxy for pupil socio‐economic deprivation

Whether someone has ever had free school meal (FSM) eligibility over a six‐year period is the measure of socio‐economic disadvantage currently used in the English school system. It is used to monitor the socio‐economic gap in achievement in the education system, to identify particular children at risk of low achievement and to direct funding to particular children and schools. In this paper we assess how well this measure predicts pupil attainment in secondary school in comparison to other measures of socio‐economic background known to influence pupil attainment, such as parental education or income. We ask whether the FSM measure is an adequate proxy for a pupil's socio‐economic disadvantage in an educational context. To do this we draw on the Longitudinal Study of Young People in England and matched administrative data. We find that the FSM eligibility measure correlates highly with other measures of socio‐economic disadvantage, however it does not identify all children living in what would be deemed deprived households. We then compare the extent to which the FSM eligibility measure predicts educational achievement relative to other measures of deprivation and find that its predictive power is only marginally lower than many richer survey measures. This provides some reassurance on its use in policy.