混合式课程教学设计质量与倾向的研究——以全国30门获奖混合式课程为例

文章通过混合方法对2019年“全国混合式教学设计创新大赛”30门获奖课程的教学设计进行分析,以阐明我国高校在混合式教学设计上的最新进展、主要问题以及所反映出的教师教学观和设计思维。研究发现,在对标FD-QM在线/混合式课程质量标准上,案例课程的活动和测评设计比较薄弱,具体表现在教师多倾向于增加互动和测试的数量与类型,但对制定教与学活动规则和评价标准则关注不足,反映出教师对混合式教学中如何认识自身角色、实践“教学存在”存在偏差。从根本上说,这是“学生中心”和“教师中心”两种不同教学观相互冲突却又纠葛的关系在教学设计中的集中体现,它提示我们在教学范式转型背景下,探讨教与学关系、师生权力、学习责任等根本性问题变得愈发重要。     

Serum lipoprotein (a) and lipid profile in young South Indian patients with myocardial infarction

Coronary artery disease is now a major health problem in India. In past few decades the battle to reduce the incidence of coronary artery disease has led the researchers to look for various clinical markers, which would help early diagnosis of the diseases. The present study was undertaken to assess the level of lipoprotein (a) [Lp(a)] and few other lipids in selected myocardial infarction (MI) patients below 45 years without having any traditional risk factors but with positive family history. Fasting blood samples were taken from 65 patients and their total cholesterol, LDL cholesterol, VLDL cholesterol, HDL cholesterol, triglycerides and serum Lp(a) were determined. The control group consisted of 50 age matched healthy individuals. The mean Lp(a) level was 58.6±3.20 mg/dl in patients and 19.70±0.18 mg/dl in controls. Thus Lp(a) levels were found significantly higher in patients with MI (p<0.05 for patients versus control) as compared to the controls. There was no significant difference in the levels of total cholesterol (TC), LDL, VLDL HDL, TGL as compared to controls but there was an increase in TC/HDL cholesterol ratio. The results of this study suggest that high level of Lp(a) and TC/HDL ratio has a distinctive association with MI, independent of other common coronary risk factors. Hence, Lp(a) level in serum emerges to be a promising marker for diagnosis of coronary artery diseases.     

Homocysteine status and acute myocardial infarction among Tamilians

Myocardial infarction is a major consequence of coronary artery disease. Apart from the traditional risk factors of myocardial infarction, recently many reports have suggested that hyperhomocysteinemia plays important role in myocardial infarction. Plasma homocysteine level was determined in 60 myocardial infarction patients and in 35 age matched healthy individuals. Statistically significant differences (p<0.01) were observed in the mean of plasma homocysteine concentrations between the acute myocardial infarction patients (24.59±6.14 mM/L) and in normal healthy individuals (13.73 ±3.54 mM/L). The level of homocysteine in myocardial infarction patients is significantly high (p <0.01) among myocardial infarction patients when compared to that of the controls. The the present study indicates a strong association between plasma homocysteine and acute myocardial infarction among Tamilians, thus implying plasma homocysteine as a possible risk factor for myocardial infarction.     

Bardet–Biedl Syndrome: A Rare Cause of Chronic Kidney Disease

Bardet-Biedl syndrome (BBS) is a rare autosomal recessive condition characterized by retinitis pigmentosa, postaxial polydactyly, central obesity, and renal involvement. Renal failure is the commonest cause of death. We report a case of BBS with chronic kidney disease (CKD) at younger age (17 year) from India. This diagnosis should be considered in patients with renal disease and the characteristic phenotype of retinitis pigmentosa, postaxial polydactyly and central obesity. These patients should undergo regular monitoring of renal function test to early diagnosis and treatment of CKD to prevent morbidity and mortality. Renal transplantation is a viable option of renal replacement therapy in these patients. These findings are valuable for comparing phenotype of BBS patients with CKD from various national and international centers.     

Down Syndrome with End-Stage Renal Disease

Down syndrome is one of the most common genetic causes of learning disabilities in children. Although the incidence of renal and urological involvement in Down syndrome is not very common, monitoring of patients with Down syndrome for renal diseases should be done regularly as patient’s age into the second and third decades. With increased survival, it appears that a growing number of these patients present with chronic renal failure. Down syndrome patients are apparently not suited for peritoneal dialysis because of lacking cooperation. This procedure can be prone to failure, mainly because of an increased risk of peritonitis. Handling such patients especially those on peritoneal dialysis is challenging. Here we report a case of Down syndrome with end-stage renal disease treated with hemodialysis for 6 months. To the best of our knowledge and current literature review this is the first case report of a patient with Down syndrome undergoing hemodialysis.     

MTHFR (Ala 222 Val) polymorphism and AMI in patients with type II diabetes mellitus

The prevalent Ala222Val single nucleotide polymorphism of the MTHFR gene has been shown to be associated with type II diabetes. The objective of the present study was to find out whether there is genetic predisposition for development of acute myocardial infarction in type II diabetes mellitus among South Indian Tamil population. PCR-based restriction enzyme analysis was performed in DNA isolated from 120 acute myocardial infarction patients with diabetes mellitus and 100 non diabetic healthy individuals with no documented cardiovascular diseases. The results indicate that the MTHFR 677TT genotype is absent in both case and controls. The MTHFR 677CT genotype was observed among 32 (26.7 %) cases and 20 (20%) controls and the MTHFR 677CC genotype among 88 (73.3%) cases and 80 (80%) controls. The allelic frequencies were in accordance to Hardy Weinberg equilibrium. There was no statistical difference in genotype distribution between cases and controls. In conclusion, we suggest that the analysis of MTHFR genotyping for C677T polymorphism alone need not be considered to find out whether there is genetic predisposition for development of acute myocardial infarction in type II diabetes mellitus among South Indian Tamil population.     

尤金·奥尼尔戏剧的古希腊悲剧思想——“精神、梦想和命运”在其作品中的体现

尤金·奥尼尔通过借鉴古希腊悲剧思想中的精神、梦想和命运三大主题创造出了自己独具特色的戏剧思想——从不逃避失败、苦难和死亡,在人生苦难背后,他昂扬的是人类不懈的追求精神,是人类为了未来和未来的高尚价值而同内心和外在的一切敌对势力搏斗时显示出的精神力量。     

Computers and School: Indian and French students' discourse

The use of digital technologies by young people and the impact of e-learning have been the subject of a significant number of studies carried out worldwide. However, when it comes to student perceptions about the place and role of these technologies in their lives, research looks towards university students. This article aims to understand what the technologies represent for school students in their personal and school lives. It is based on a study that brings together two contexts, representing opposing cultures and trends: France where the policy on school computers has been in place for more than two decades and India where the government has only recently begun to make efforts to overcome the digital divide. This study conducted in the two countries in 2009 among 960 young people aged between 11 and 18 shows the importance of schools in constructing private spaces to be shared with peers, a role that has long been attributed to home computers. This article thus provides elements of explanation for the relative disenchantment that young people feel for the school-related uses of the technologies. For them, school is not about individualist autonomous learning, but about learning from teachers as a group.     

Partial Empty Sella Syndrome: A Case Report and Review

Empty sella syndrome is a damaged pituitary gland. Either the gland has shrunk or has been crushed and flattened making it look like an empty sella on MRI scan. The reported prevalence of primary empty sella in general population is 8–35 %. The incidence is more in females, the ratio being 5:1. It is generally found in middle aged women who are obese and hypertensive.