Does modality matter? A latent profile and transition analysis of sedentary behaviours among school-aged youth: The UP&DOWN study

ABSTRACT

The aims of this study were to identify profiles of sedentary behaviour (SB) patterns, based on leisure-time self-reported SB modalities (screen, educative, social, and relaxing) and to evaluate changes in these profiles over 2 years among Spanish youth aged 8–18 years. Latent profile analysis (LPA), a data-driven analytic approach, was used to identify groups of boys and girls (n = 1553; 48% girls; mean±SD age: 12.56 ± 2.49 y) with distinct SB profiles using the SB modalities (time/d) as input variables. Latent transition analysis, an extension of LPA that uses longitudinal data, was used to analyse 2-year changes in these profiles. At baseline, four and three SB profiles were found among boys (labelled: screen, educative, social, and relaxing) and girls (labelled: screen/social, educative, and relaxing), respectively. Overall, more girls (range: 48%-67%) had the same profile over time, than boys (40%-52%). Participants with a screen or relaxing SB profile at baseline were more likely to have an educative profile after 2 years. Youth with a social and an educative SB profile at baseline were more likely to transition to profiles characterized by higher screen and social SB, respectively. Using a novel and person-centered approach, this study identified gender-specific SB profiles that were moderately stable over time.     

Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

A meta-cognitive approach to doping in sports: The effects of thought validation on attitudes related to doping

ABSTRACT

To better understand doping-related attitude change, it is important to consider not only the amount of thinking (i.e., elaboration) done by message recipients, but also the favourability of their thoughts in response to the proposal, as well as the perceived validity in their thoughts. The main goal of the present study was to analyse the effects of a meta-cognitive process (i.e., thought validation) on attitudes related to doping. Thus, we randomly assigned participants to read a message either against or in favour of legalising several doping behaviours. Participants listed their thoughts regarding the proposal and indicated the perceived validity in their thoughts, then reported their attitudes. As hypothesised, the message against legalisation elicited more unfavourable thoughts and attitudes than the message in favour of legalisation. Most relevantly, the effects of the message direction on attitudes were greater for participants with higher (vs. lower) levels of thought validity. Furthermore, consistent with the thought validation process, results revealed that thought favourability was a better predictor of attitudes for participants with higher (vs. lower) perceived thought validity, indicating that perceiving one’s thoughts as valid plays an important role in persuasion. These findings provide novel insights for research and interventions regarding doping in sports.     

Measuring Search Engine Quality

The effectiveness of twenty public search engines is evaluated using TREC-inspired methods and a set of 54 queries taken from real Web search logs. The World Wide Web is taken as the test collection and a combination of crawler and text retrieval system is evaluated. The engines are compared on a range of measures derivable from binary relevance judgments of the first seven live results returned. Statistical testing reveals a significant difference between engines and high intercorrelations between measures. Surprisingly, given the dynamic nature of the Web and the time elapsed, there is also a high correlation between results of this study and a previous study by Gordon and Pathak. For nearly all engines, there is a gradual decline in precision at increasing cutoff after some initial fluctuation. Performance of the engines as a group is found to be inferior to the group of participants in the TREC-8 Large Web task, although the best engines approach the median of those systems. Shortcomings of current Web search evaluation methodology are identified and recommendations are made for future improvements. In particular, the present study and its predecessors deal with queries which are assumed to derive from a need to find a selection of documents relevant to a topic. By contrast, real Web search reflects a range of other information need types which require different judging and different measures.     

Medical history for tomorrow—preserving the record of today

This paper addresses the need to recognize the importance, and the challenges, of preserving the hugely expanding record of medicine today for historians of the future. We are faced not only with an increase in traditional publishing formats, but also with the rapid growth in electronic communications. Two celebrated medical cases, one from the late seventeenth century and one from the late twentieth, are used to illustrate the differences and the difficulties. The need for active and effective professional collaboration is stressed; libraries should work together to address these issues.