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1.
Ritu Sharma Mridula Mahajan Ravi Kant 《Indian journal of clinical biochemistry : IJCB》2004,19(1):10-13
Serum total lipids (cholesterol and triglyceride), lipoproteins (VLDL, LDL and HDL) and Apolipoprotein-B levels of normal
healthy individuals (n=25) and coronary artery disease patients (n=25) were estimated. The objective of the present study
was to ascertain the role of apo-B in causation and inheritance of coronary artery disease. It was observed that on an average
serum total cholesterol and triglyceride more than 200 mg/dl bring the individuals to a risk of coronary artery disease (CAD)
irrespective of the age. CAD patients achieved this value at an early age (35–45 years). Similarly VLDL and LDL levels were
found to be significantly raised in CAD patients when compared to that of age matched normal individuals, with patients achieving
risk values at an early age. HDL levels were found to be significantly lower in CAD patients as compared to normal individuals.
Serum apo-B levels were significantly raised in CAD patients as compared to age matched normal individuals. Patients with
positive family history of CAD had raised serum apo-B levels than those having negative family history. A positive coefficient
of correlation was observed between serum apo-B and LDL levels suggesting that more the number of Apo-B particles, more will
be the synthesis of atherogenic particle (LDL). Patients with negative family history had serum apo-B levels closer to those
of normal individuals and in these individuals HDL levels were found to be significantly lowered, suggesting that loss of
scavenger role of HDL could be the risk factor responsible for the causation of CAD in these patients, with negative family
history of coronary artery disease. 相似文献
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Vitamin C in Disease Prevention and Cure: An Overview 总被引:1,自引:0,他引:1
Shailja Chambial Shailendra Dwivedi Kamla Kant Shukla Placheril J. John Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2013,28(4):314-328
The recognition of vitamin C is associated with a history of an unrelenting search for the cause of the ancient haemorrhagic disease scurvy. Isolated in 1928, vitamin C is essential for the development and maintenance of connective tissues. It plays an important role in bone formation, wound healing and the maintenance of healthy gums. Vitamin C plays an important role in a number of metabolic functions including the activation of the B vitamin, folic acid, the conversion of cholesterol to bile acids and the conversion of the amino acid, tryptophan, to the neurotransmitter, serotonin. It is an antioxidant that protects body from free radical damage. It is used as therapeutic agent in many diseases and disorders. Vitamin C protects the immune system, reduces the severity of allergic reactions and helps to fight off infections. However the significance and beneficial effect of vitamin C in respect to human disease such as cancer, atherosclerosis, diabetes, neurodegenerative disease and metal toxicity however remains equivocal. Thus further continuous uninterrupted efforts may open new vistas to understand its significance in disease management. 相似文献
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Pragya Dwivedi Vibhor Kant Kamal K. Bharadwaj 《Education and Information Technologies》2018,23(2):819-836
With the rapid advancement of information and communication technologies, e-learning has gained a considerable attention in recent years. Many researchers have attempted to develop various e-learning systems with personalized learning mechanisms for assisting learners so that they can learn more efficiently. In this context, curriculum sequencing is considered as an important concern for developing more efficient personalized e-learning systems. A more effective personalized e-learning recommender system should recommend a sequence of learning materials called learning path, in an appropriate order with a starting and ending point, rather than a sequence of unordered learning materials. Further the recommended sequence should also match the learner preferences for enhancing their learning capabilities. Moreover, the length of recommended sequence cannot be fixed for each learner because these learners differ from one another in their preferences such as knowledge levels, learning styles, emotions, etc. In this paper, we present an effective learning path recommendation system (LPRS) for e-learners through a variable length genetic algorithm (VLGA) by considering learners’ learning styles and knowledge levels. Experimental results are presented to demonstrate the effectiveness of the proposed LPRS in e-learning environment. 相似文献
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Janardan Krishna Yadav Deepika Chandra Verma Srinivas Jangirala Shashi Kant Srivastava 《The Journal of High Technology Management Research》2021,32(1):100404
The concept of smart tourism remains fuzzy when it comes to practice because of the lack of clarity on the roles and responsibilities of stakeholders in addition to complex institutional ecosystem that exist within the tourism industry. Further, trust and safety of the data generated due to the advancement of smart tourism in varied institutional arrangements pose huge challenges. Extant literature proposes that the application of decentralized ledger promises possible solutions to most of these problems due to the inherent features of the Blockchain technology. This suggestion raises two practical questions. First, does the sophisticated additional layer adds complexity to its practical application? Second, will the suggested solutions really lead to a win-win for all the stakeholders involved? In this study, we use Ostrom's action arena to examine the exchanges (information, contractual and monetary) between various stakeholders in a BCT enabled smart tourism of a Blockchain enabled tourism industry to answer these two questions. 相似文献
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Saroj Kant Sinha Satya Vati Rana Deepak Kumar Bhasin Kusum Joshi 《Indian journal of clinical biochemistry : IJCB》2005,20(1):169-172
Duodenal ulcer is a common disease and is considered acid-peptic disease. Duodenal ulcer patients are known to have higher
incidence of antral gastritis and duodentitis than general population. Thus one can expect some alteration in the enzyme products
of mucosal cells of antrum and duodenum in this condition. The present study was planned in 30 patients of duodenal ulcer
and 30 of non-ulcer dyspepsia. After overnight fast, upper gastrointestinal endoscopy was done using forward viewing fibreoptic
endoscope. Two pairs of biopsies were taken from the antrum and two from the descending duodenum using standard biopsy forceps.
One pair of biopsy from each site was taken in 10% formal saline for histopathological examination. One pair of biopsies from
each site was collected in saline for the measurement of disaccharidases by Dahlquist method. Activities of lactase, sucrase
and maltase were significantly higher in descending duodenum mucosa as compared to antral mucosa in both groups. Activities
of these enzymes in antrum and duodenum of both groups did not differ significantly. No significant difference was found in
disaccharidases in antrum and descending duodenum in patients with or without histological gastritis. This study suggests
that the disaccharidases do not change in antrum and duodenum of ulcer patients as compared to the patients with non-ulcer
dyspepsia. 相似文献
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Mridula Mahajan Sukhraj Kaur Shruti Mahajan Ravi Kant 《Indian journal of clinical biochemistry : IJCB》2009,24(2):205-207
Uric acid an endogenous aqueous antioxidant in normal humans is present in much higher concentrations than vitamin C and has
been known to cover 2/3rd of the free radical scavenging capacity in plasma. In the present study average uric acid levels of patients of rheumatoid
arthritis were found to be close to the normal individuals. A unique feature was observed after classifying the patients on
the basis of the duration of suffering, the patients having longer duration of disease had least uric acid levels as compared
to those suffering from relatively lesser period, similar trend was observed in the ascorbic acid estimations. The decline
in uric acid values with progression of the disease was much more than what was observed in case of ascorbic acid suggesting
the significant role of uric acid in scavenging of free radicals. Too much lowering of Uric Acid should be checked and vitamin
C should be supplemented in diet for maintaining the balance between pro oxidant and antioxidant forces to check pro oxidant
insult in rheumatoid arthritis. 相似文献
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