Carnosine in health and disease

Abstract

Carnosine was originally discovered in skeletal muscle, where it exists in larger amounts than in other tissues. The majority of research into the physiological roles of carnosine have been conducted on skeletal muscle. Given this and the potential for muscle carnosine content to be increased with supplementation, there is now a large body of research examining the ergogenic effects (or otherwise) of carnosine. More recent research, however, points towards a potential for carnosine to exert a wider range of physiological effects in other tissues, including the brain, heart, pancreas, kidney and cancer cells. Taken together, this is suggestive of a potential for carnosine to have therapeutic benefits in health and disease, although this is by no means without complication. Herein, we will provide a review of the current literature relating to the potential therapeutic effects of carnosine in health and disease.     

Book reviews

Association of Research Libraries     

Risk management information for HIV infection

This article discusses HIV infection in terms of the risk manager's information needs in the health care environment. The malpractice problem, increasing workman's compensation suits, the greater role of the ombudsman, implementation of the National Practitioner Data Bank, and the Joint Commission on Accreditation of Health Care Organizations' (JCAHO) emphasis on clinical excellence are conditions which have given greater importance to the risk manager's position. Included in this article are hedges to retrieve various components of risk management and a select bibliography from AIDSLINE.     

The inadvertent creation of a neocolonial culture: A study of western sojourners in India

Field work and structured interviews with 139 foreign sojourners in India were analyzed to describe the socialization of aliens into their role. Attitude scales measuring favorability toward the host country and people were also examined in relation to the respondent's occupational status and elapsed time in India. The results from the field work and interviews suggest that the privileges and high status accorded many Western visitors may contribute to the visitors' derogation of their hosts, a process which is often subtle but unmistakable. The visitors appear to become socialized into the world of aliens rather than the world of their hosts. The higher the visitor's status and the longer the elapsed time in India, the more pronounced these patterns appear. While the correlational nature of the study makes it impossible to determine whether persons with initially unfavorable attitudes are selected into the high status positions or whether the positions themselves create such attitudes, it appears reasonable to conclude that there would be less derogation and alienation if the lures of status and money were removed; persons would be neither selected nor influenced by such factors.     

Body composition of female road and track endurance cyclists: Normative values and typical changes

The aims of this study were to describe normative values and seasonal variation of body composition in female cyclists comparing female road and track endurance cyclists, and to validate the use of anthropometry to monitor lean mass changes. Anthropometric profiles (seven site skinfolds) were measured over 16 years from 126 female cyclists. Lean mass index (LMI) was calculated as body weight?×?skinfolds^?x. The exponent (x) was calculated as the slope of the natural logarithm of body weight and skinfolds. Percentage changes in LMI were compared to lean mass changes measured using dual-energy X-ray absorptiometry (DXA) in a subset of 25 road cyclists. Compared to sub-elite and elite cyclists, world class cyclists were (mean [95% CI]) 1.18?kg [0.46, 1.90] and 0.60?kg [0.05, 1.15] lighter and had skinfolds that were 7.4?mm [3.8, 11.0] and 4.6?mm [1.8, 7.4] lower, respectively. Body weight (0.41?kg [0.04, 0.77]) and skinfolds (4.0?mm [2.1, 6.0]) were higher in the off-season compared to the early-season. World class female road cyclists had lower body weight (6.04?kg [2.73, 9.35]) and skinfolds (11.5?mm [1.1, 21.9]) than track endurance cyclists. LMI (mean exponent 0.15 [0.13, 0.18]) explained 87% of the variance in DXA lean mass. In conclusion, higher performing female cyclists were lighter and leaner than their less successful peers, road cyclists were lighter and leaner than track endurance cyclists, and weight and skinfolds were lowest early in the season. LMI appears to be a reasonably valid tool for monitoring lean mass changes.     

What Is Wrong with Practicum?: some reflections

The purpose of this study was to examine students’ perceptions of previously identified negative aspects of practicum during preparation courses for careers in the field of early childhood education. Students at each of three year levels of the course earlier had been surveyed using a Likert‐type instrument following recent practicum experiences. Item frequency analysis was conducted for each separate year group's responses and for the combined group. Analysis of data from the combined responses included item properties, item‐scale relationships, scale properties and instrument factor analysis. Results of factor analysis revealed seven interpretable stressors, the most serious being the cluster labelled ‘physical demands’. The 10 most negative aspects for each year level (i.e. items with the lowest means) were compiled in a subsequent instrument similar to the original but also including a request for explanatory comments following each item. These three instruments were administered at the end of the same year. Student comments on the latter instruments clarified the statistical results and are presented here in the categories of ‘demands on students’, Hime and energy’, ‘coping with written requirements’, and ‘conforming with mistrusted practices’. Reflections on the implications of this illumination of statistical analysis are then presented.