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This study examined issues in supporting middle-school teachers to become more learner centered when implementing computer-based, workplace simulations in their classrooms. Specifically, this report focuses on a participant observation study of two teachers to develop and evolve a framework for professional development. The framework was developed based on prior professional development efforts, information on developing learner-centered classrooms, and data about teacher change. The framework included five key pieces: (a) reflection, (b) proximal goals, (c) collegial support groups, (d) one-on-one feedback, and (e) support materials for the teachers. The foundation for the framework was a belief that change is individual and needs to be supported in context and over time. The data included field observations as the teachers used the simulations in their classrooms made by the author and three outside observers, and interviews with each teacher following her use of the simulation program. During the four-month study, the original framework evolved in response to the data collected. The final version of the framework focuses on the professional developer working with teachers to develop reflective skills. Proximal goals became a focusing tool for reflection after teachers had begun to develop their reflective skills. The interplay between reflection and proximal goals was enhanced by outside resources, one-on-one feedback, and collegial group meetings. The work reported here was comp;eted as part of a dissertation conducted at Indiana University’s Center for Innovation in Assessment, and was supported in part by grants from the Andrew W. Mellon Foundation and the Russell Sage Fundation. The school and participant names have been changed to protect their identity. All researcher names are actual.  相似文献   
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Variability in analytical performance of some analyte indicated the need of evaluation of quality plan of our laboratory. We tried to put the same degree of effort into our quality metrics as we put into the laboratory processes themselves. Application of six sigma methodologies improve the quality by focusing on the root causes of the problems in performance and analyzing by flowcharts, fishbone diagrams and other quality tools. Sigma metric was calculated for laboratory parameters for a period of 8 months during 2018–19. The analytes with poor sigma metric were free Thyroxine (FT3, FT4), Sodium, Calcium and Magnesium. Sigma metric of free Thyroxine (FT3, FT4), Sodium, Calcium and Magnesium were below 3. A road map for process improvement was designed with DMAIC (Define-Measure-Analyze-Improve-Control) model to solve the issue. Possible causes for low analytical performance of the particular analytes were depicted in Fishbone diagram. The Fishbone analysis identified the water quality issues with electrolyte analysis while high ambient temperature was culprit for poor assay performance of free Thyroxine. Sigma metric of the analytical performance was assessed once again after root cause analysis. Sigmametric showed marked improvement in control phase. Identification of problems led to reduction in non value added work leading to adequate resource utilization by addressing the priority issue. Therefore, DMAIC tool with Fish bone model analysis can be recommended as a well suited method for troubleshooting in poor performance of laboratory parameter.  相似文献   
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Editorial     
Kaushal Verma 《Resonance》2017,22(10):905-906
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Deficiency or excess of certain trace elements has been considered as risk factor for prostate cancer. This study was aimed to detect differential changes and mutual correlations of selected trace elements in prostate cancer tissue versus benign prostatic hyperplasia tissue. Zinc, copper, iron, calcium and selenium were analysed in histologically proven 15 prostate cancer tissues and 15 benign prostatic hyperplasia tissues using atomic absorption spectrophotometer. Unpaired two tailed t test/Mann–Whitney U test and Pearson correlation coefficient were used to compare the level of trace elements, elemental ratios and their interrelations. As compared to benign prostatic tissue, malignant prostatic tissue had significantly lower selenium (p = 0.038) and zinc (p = 0.043) concentrations, a lower zinc/iron ratio (p = 0.04) and positive correlation of selenium with zinc (r = 0.71, p = 0.02) and iron (r = 0.76, p = 0.009). Considerably divergent interrelationship of elements and elemental ratios in prostate cancer versus benign prostatic hyperplasia was noted. Understanding of differential elemental changes and their interdependence may be useful in defining the complex metabolic alterations in prostate carcinogenesis with potential for development of element based newer diagnostic, preventive and therapeutic strategies. Further studies may be needed to elucidate this complex relationship between trace elements and prostate carcinogenesis.  相似文献   
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Now a days measurement of molecular forms of PSA has gained importance in clinical practice. Several studies have demonstrated the production of PSA in female tissues, such as breast. The present piece of work has been undertaken with an objective to estimate the relative proportion of the molecular forms of PSA in serum along with serum testosterone in benign and malignant breast tumor cases and to analyze their association with the severity of the disease process 34 malignant and 26 benign breast disease cases along with 33 healthy controls of same age group were enrolled in this study for evaluation. Serum testosterone was measured by ELISA, whereas serum total PSA (TPSA) and free PSA (FPSA) were estimated by electrochemiluminescence immunoassay. A significant rise of fasting plasma glucose along with prominent dyslipidemia was observed in breast tumor cases. Marked rise in serum testosterone as well as TPSA and FPSA was documented in both benign and malignant breast tumor cases. Serum testosterone revealed a significant positive association with both TPSA and FPSA pointing towards an etiological association between them. However, surgical removal of tumor mass resulted in a marked decline of presurgical value of both TPSA and FPSA with a non-significant fall in serum testosterone revealing tumor tissue as the source of FPSA and TPSA. Thus, estimation of PSA provides prognostic information that may assist in future treatment.  相似文献   
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Thyroid function tests are very important for the diagnosis and monitoring of patients with thyroid dysfunction. The guidelines recommend serum thyroid stimulating hormone (TSH) as the single most reliable test to diagnose all common forms of hypothyroidism and hyperthyroidism. The aim of this study was to analyze the ordering pattern for thyroid function tests by physicians and the analysis of results based on the clinical history. The mean age of the patients was 32.5 ± 6.5 years. Majority of samples (87.7% of total) were received from the departments of Medicine and Gynae. Thyroid profiles (47.5%) were ordered more frequently as compared to TSH only (46%). There was no significant difference in the percentage of normal reports for both types of tests. 77.8% of TFT and 76.6% of TSH samples had results within the reference range. The percentage of abnormal results was 13.7% in the patients who were screened for thyroid disorders. There is a need to redefine the case definition for thyroid dysfunction and order the appropriate test in a rational and cost effective manner.  相似文献   
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Skilled manpower forecasts are considered the essence of national or regional manpower planning. A variety of such forecasts in such a vast and complex country as India is not unexpected. Skilled manpower was and continues to be considered an essential building block for nation-building in most developing countries including India. Indeed, it has been difficult to rationalise expenditure on most new educational institutions — technical or non-technical — in India with its vast problems of high illiteracy and low per capita income without some manpower demand forecasts.Given this setting, this paper has attempted to take a close and dispassionate look at the experience of India in manpower planning, especially since Independence. The paper has reviewed the methodology used in the various exercises made for such forecasts — sometimes done right up to matriculation level — and attempted many realisation comparisons. Even for the high professional categories such as engineers, scientists and doctors it has found serious discrepancies. While it has tried to rationalise them and assessed their actual impact on educational decision-making, it had to take note of very serious data constraints which make both supply and demand estimates difficult. The data situation in the predominantly agrarian Indian economy has therefore been carefully reviewed and suggestions for adjustments and improvements of data made.Since occupational structures and their evolution are almost a sine qua non of a classical manpower requirements approach, the paper takes a close look at the latest available data from the Census and other sources. It certainly found growth in occupational divisions 0, 1 and 2, but sometimes cannot separate the genuine growth from that due to the ‘supply’ effect. Despite all these limitations the paper notices that manpower planning activity continues to be favoured at practically all levels — national, State, regional or industrial.  相似文献   
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