Putative Role of Cardio Metabolic Risk Among Poorly Controlled Asthmatics in South Indian Population

Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30). Centrifuged fasting venous blood samples were used for biochemical analysis, pulmonary function test, BMI, and waist hip ratio (WHR) were measured. The statistical analysis was done using SPSS version 17. There was a significant increase in BMI, WHR, lipid profile, serum uric acid and decrease in forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC in poorly controlled asthmatics. There was a significant association between FEV1 and serum uric acid, BMI and Triacylgycerol in poorly controlled asthmatics. Poorly controlled asthmatics have greater risk of developing cardiometabolic problems. Serum uric acid can be used as one of the severity markers in asthma to assess cardio metabolic risk.     

Open educational practices of SWAYAM programme among research scholars

Open Educational Resource creates an opportunity for researchers to learn the openly available online educational resources. OER are publicly and freely licensed electronic resources that offer a remarkable chance for researchers everywhere to share, utilize, and reuse resources. It is a must for researchers to practices these resources to enhance research outcomes. The present study aims at practicing the open educational resources of the state universities of Tamilnadu research scholars on their SWAYAM programme. This study also attempts to determine the research scholars' level of open educational practices on their SWAYAM through appropriate methodological and statistical procedures. From the 300 state universities of Tamilnadu, research scholars are select as the study sample by adopting a simple random sampling method. Hence, the findings and suggestions of the study have much significance to the many research scholars.

     

UV-B Induced stimulation of phosphatidylinositol 3-kinase in human fetal hepatocytes

We investigated the effect of UV-B irradiation on PI 3-kinase activity in human fetal hepatocytes. When cells were exposed to monochromatic (304nm) UV-B light, a significant increase in intracellular PI 3-kinase activity was observed in a dose dependent manner with maximal activity upon 1500 Jm⁻² irradiation. At 1500 Jm⁻² dose PI 3-kinse activity increased by 80% in membrane fraction of fetal hepatocytes of 25 weeks gestation. PI 3-kinse inhibitors wortmannin and LY294002 specifically inhibited the UV-B induced lipid kinase activity and blocked significantly the UV-B induced cell viability. The data suggests a correlation between cell survival and elevated levels of PI 3-kinase and suggest that UV-B irradiation at a dose of 1500 Jm⁻² is ideal for fetal hepatocyte transplantation. Also, PI 3-kinase levels could be a representative marker for viable UV-B irradiated fetal hepatocytes for transplantation.