运动因子在心血管功能中的调控作用及相关机制研究进展

心血管疾病(cardiovascular disease,CVD)是包括动脉粥样硬化、心力衰竭、心脏缺血后再灌注损伤和心肌梗死等血管和心脏的复杂病症。血管内皮细胞、平滑肌细胞和心肌细胞生理功能障碍是诱发CVD的关键因素。研究表明,运动能够对心脏和动脉的形态、功能起到积极的调控作用,可作为CVD非药物疗法的重要手段之一。运动可通过调控多种运动因子的表达水平,如肌肉分泌的Fstl1、Irisin和MSTN,脂肪分泌的Omentin、Apelin、CTRP3和CTRP9,肝脏分泌的FGF21、ANGPTL3和ANGPTL4等,进而调控血管内皮细胞、平滑肌细胞和心肌细胞的分化、增殖和凋亡,从而发挥其防治CVD作用。本文试图梳理肌肉、脂肪和肝脏分泌的运动因子与调控心脏和动脉功能之间的相关信号通路及其机制,为运动干预防治CVD提供新的思路。     

What motivates enrolment in programming MOOCs?

Learners who enrol in massive open online courses (MOOCs) have different backgrounds and tend to have different motivations than learners in traditional courses. Based on value-expectancy theory, an instrument was developed to measure motivation for enrolling in a programming MOOC. A study with 1229 adult participants in Estonian-language programming course “About Programming” was conducted to validate the instrument. Results of confirmatory factor analysis validated the 7-factor scale named factors influencing enrolment in MOOC (FIEM). FIEM comprises three factors of expectancies, three factors of values and one factor of social influence. The highest and lowest rated motivational factors influencing enrolment in programming MOOC are discussed in the paper. Interest in and expectations for the course, personal suitability of distance learning and suitability for family and work are the highest-rated motivational factors for those who enrol in MOOC. Usefulness related to own children, social influence and usefulness to related to certification were the lowest rated. The results of this study can be useful for designers of programming MOOCs and the developed scale might be used in future studies.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

The Influence of Hygroscopic Materials on the Fluctuation of Relative Humidity in Museums Located in Historical Buildings

ABSTRACT

The preservation of artefacts in museum collections is profoundly affected by fluctuations in temperature and, especially, relative humidity (RH). Since the late nineteenth century, many studies have been carried out on the best way to control hygrothermal conditions. In old buildings located in maritime temperate climate zones (such as Portugal) with strong thermal inertia, and which have low ventilation rate (relative to the volume and number of visitors), daily and seasonal hygroscopic inertia may help to assure the maintenance of RH stabilization conditions. The use of expensive active systems may be minimized through the passive behaviour of internal finishing building materials. This work presents the results of an experimental laboratory study conducted in a flow chamber to demonstrate the enormous potential of hygroscopic materials in stabilizing interior relative humidity. Based in these results and in-situ monitoring in a museum housed in a building, located in Porto, with a typical construction of the 1950s (granite masonry and reinforced concrete slabs), a numerical analysis was done to quantify the influence of hygroscopic materials in stabilizing the interior relative humidity.     

现阶段国内U-15少年足球守门员防守技术运用情况调研

运用临场观察、访谈、文献资料调研以及逻辑分析等研究方法 ,对现阶段国内U 15少年足球守门员防守技术运用情况进行统计与分析研究。研究表明 ,少年足球守门员防射门球的预测判断能力不足 ,导致选位差、反应慢和接球易脱手 ,防守的成功率低 ;出击时机把握不好 ,对抗条件下难以有效发挥位置优势 ,强干扰下争夺球失误多。加强足球意识与心理培养 ,提高反应和接球动作质量要求是加强少年足球守门员水平稳定的重要环节。     

论新疆旅游资源开发及旅游业发展问题

新疆旅游资源丰富多彩 ,极具特色。上世纪 90年代以来 ,旅游业虽有较快发展 ,但仍不发达 ,与自身的资源优势极不相称。新疆旅游业要在 2 1世纪获得发展 ,必须彻底转变观念、科学规划、整体优化布局 ,多方面采取措施     

我国职业篮球俱乐部运行管理中的法律问题研究

从职业篮球俱乐部的成立、我国职业篮球俱乐部的外部关系、与运动员有关的法律问题、与我国职业篮球俱乐部经营开发有关的法律法规以及关于体育纠纷的问题五个方面进行论述 ,寻求适合我国职业篮球俱乐部的发展道路     

运动员流畅心理状态研究概况

介绍流畅心理状态的一般概念、流畅心理状态的主要特征以及国内外对于流畅心理状态研究的动态,并对当 前对于流畅心理状态研究的现状进行简要的评述,旨在为我国运动心理学工作者更好地了解流畅心理状态的研究动 态提供参考和借鉴。     

青年女子排球运动员弹跳力模型的研制

为了探索发展青年女子排球运动员弹跳力的有效途径 ,以四川青年女子排球队 9名运动员和重庆女子排球队 13名运动员为研究对象 ,对有关弹跳力的多种因素进行了相关、多元回归分析 ,进而制定出发展弹跳力的回归模型 ,为青年女子排球运动员弹跳力训练提供参考     

第27届奥运会前8名国家竞技体育成功经验及失利教训分析

对第 2 7届奥运会金牌榜前 8名国家发展竞技体育的成功经验及失利教训进行了客观分析。研究表明 ,合理开发、利用及配置竞技体育人力、财力、物力、信息、科技、体制等资源是各国竞技体育保持持续发展的重要成功经验。竞技体育经费不足及备战质量不高等因素成为制约2 7届奥运会竞技体育失利国家的重要因素