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��[Purpose/significance] The accumulation and inheritance of knowledge promotes the development of human society. This paper proposes to study the inheritance and variation of knowledge by using the knowledge gene of scientific and technological literature, in order to have a more intuitive and comprehensive perspective on the inheritance and development of knowledge.[Method/process] By analyzing the narrow and broad definitions of knowledge genes, the research significance of knowledge genes was determined and their specific research objects were discussed. Two ways of expression of knowledge genes in scientific and technological literature were proposed, and the types of knowledge genes in scientific and technological literature were analyzed. The main factors affecting the inheritance and variation of knowledge genes were summarized, and the inheritance of knowledge genes was designed. And the method of variation.[Result/conclusion] The identification of knowledge genes in scientific and technological literature can effectively reveal the knowledge inheritance and iteration between different documents, and promote the development and perfection of the theoretical system of knowledge memes.  相似文献   
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