固—液相转移催化合成1—氰基环丁烷—1—羧酸乙酯

以ＰＥＧ６００为相转移催化剂，无水碳酸钾为碱，１，２－二氯乙烷为溶剂；氰基乙酸乙酯和１，３－二溴丙烷为反应原料，经缩合反应较高产率的合成１－氰基环丁烷－１－羧酸乙酯，收率达６４％，此方法反应条件温和，原料便宜易得，操作简便安全。     

Application of response surface methodology in medium optimization for pyruvic acid production of <Emphasis Type="Italic">Torulopsis glabrata</Emphasis> TP19 in batch fermentation

Response surface methodology （RSM） was used to optimize the fermentation medium for enhancing pyruvic acid production by Torulopsis glabrata TP19. In the first step of optimization, with Plackett-Burman design, ammonium sulfate, glucose and nicotinic acid were found to be the important factors affecting pyruvic acid production significantly. In the second step, a 23 full factorial central composite design and RSM were applied to determine the optimal concentration of each significant variable. A second-order polynomial was determined by the multiple regression analysis of the experimental data. The optimum values for the critical components were obtained as follows： ammonium sulfate 0.7498 （10.75 g/L）, glucose 0.9383 （109.38 g/L） and nicotinic acid 0.3633 （7.86 mg/L） with a predicted value of maximum pyruvic acid production of 42.2 g/L. Under the optimal conditions, the practical pyruvic acid production was 42.4 g/L. The determination coefficient （R^2） was 0.9483, which ensures adequate credibility of the model. By scaling up fermentation from flask to jar fermentor, we obtained promising results.     

发酵法生产丙酮酸的工艺条件优化研究

丙酮酸是一种重要的有机酸.为提高发酵法生产丙酮酸的转化率,研究了初始葡萄糖质量浓度、供氧、补糖方式和流加培养中氮的供给对光滑球拟酵母发酵生产丙酮酸的影响,发现葡萄糖质量浓度在116.2g/L左右较为适宜;实行分阶段供氧控制模式可实现高产量、高产率和高葡萄糖消耗速度;采用连续补糖方式可获得较高的丙酮酸产量;用氨水代替KOH控制pH值进行流加培养发酵过程中,细胞表现出很强的丙酮酸合成能力.     

山梨酸乙酯的合成研究

以对甲苯磺酸为催化剂,催化合成山梨酸乙酯。考察了原料配比、催化剂的用量、带水剂的用量以及反应时间等条件对反应的影响。实验结果表明,合成山梨酸乙酯的最佳反应条件是：n（山梨酸）：n（乙醇）=1：5,催化剂用量占山梨酸质量的25％,反应时间3h,带水剂用量为15mL,产物收率75．04％,纯度达98％。     

香豆素-3-羧酸乙酯的水热合成和表征

利用水热反应,在无水乙醇介质中,以水杨醛为原料,二乙胺为催化剂,与有活泼亚甲基的丙二酸二乙酯发生反应,合成化合物香豆素-3-羧酸乙酯。经IR、1H NMR和元素分析,确认了其结构。     

Photocatalytic Degradation of Diethyl Phthalate with Surfactant Addition

This paper studies the adsorption of diethyl phthalate (DEP,an environmental hormone) on the surface of nanoscale TiO_2, effects of pH value of solutions, initial concentrations of DEP and additive surfactant on photocatalytic degradation and dynamics of DEP. Under ultra violet illumination, the interaction between DEP and surfactants including DBS (sodium dodecylbenzenesulfon-ate), CTAB (cetyltrimethylammonium bromide), and OP-10 (nonylphenol polyoxyethylene ether) was exploited from the perspective of degradation speed calculated by the data of high pressure liquid chromatography (HPLC) and UV-Vis spectra, respectively. Photocatalytic degradation of DEP followed pseudo first-order reaction kinetics. DEP as substrate degraded fast when its initial concentration was 130 mg/L. TiO_2 had certain adsorption ability of DEP. TiO_2 could adsorb the most DEP at the approximately neutral pH of 6.91. Degradation of DEP was not affected obviously by additives OP-10 and DBS. Degradation rate of DEP was not enhanced greatly in the presence of surfactants, but degradation of DBS was sped up. Degradation rate of DEP was depressed in the presence of additive CTAB. The more CTAB was added, the less DEP was degraded. Degradation rate of CTAB became slow with the increase of initial CTAB concentration. The possible adsorption models among TiO_2, DEP and surfactants were given.     

2-（4-溴甲基苯基）丙酸乙酯的合成工艺研究

目的：提高合成洛索洛芬钠的中间体2-(4-溴甲基苯基)丙酸乙酯的收率；方法：改变催化剂为四氯化铝，缩短工艺路线；结果：收率较文献结果高，且对环境污染小，原料易获得，副产物少；结论：改进后的方法取得了很好的效果，总收率62％(原文献36％)。     

α—硫羧基硫代甲酰胺与丁炔二酸二乙酯的反应探索

本文研究了α－硫代苯甲酰基硫代甲酰吗啉与丁炔二酸二乙酯的反应。结果表明生成的产物为取代噻吩。     

苯巴比妥合成方法的绿色化研究

苯乙酸乙酯与碳酸二乙酯进行Claisen酯缩合后,不经加热脱羧,直接得苯丙二酸二乙酯而制备苯巴比妥,实现了苯巴比妥合成工艺的绿色化。     

对硝基苯腙基取代丙二酸二乙酯的合成及晶体结构

在冰盐浴条件下,对硝基苯胺重氮盐与丙二酸二乙酯反应,合成了标题化合物C_(13)H_(15)N_3O_7。经IR、~1HNMR、元素分析和X-射线单晶测定,确认了其结构。化合物属单斜晶系,C2/c空间群,晶胞参数:α=14.331(11)■,b=6.847(5)■,c=32.63(3)■,β=98.149(14)°,V=3169(4)■~3,Z=8,D_c=1.364Mg/m~3,μ=0.112 mm~(-1),F (000)=1360,R=0.0783,wR=0.2461。