静默疗法对肿瘤化疗病人恶心、呕吐的防治作用

目的探索静默疗法对肿瘤化疗副反应的作用。方法将300例进行化学治疗的肿瘤病人随机分为对照组和试验组,每组各150例病人。对照组进行治疗时,只用常规的恩丹西酮预防恶心、呕吐等副作用;而试验组除了用恩丹西酮外,在受过专门训练护理人员的指导下用静默疗法辅助治疗来预防恶心、呕吐等副作用。结果试验组胃肠道等副反应控制率为57%,与对照组(43%)比较,有显著性差异(P<0.05)。结论静默疗法有减轻或防止化疗药物引起的胃肠道反应等副反应的作用。     

肿瘤放化疗：利多弊多？

美国肿瘤协会在2001年就公布，60岁以上的恶性肿瘤者不提倡做放化疗，因为放化疗只会缩短病人的生存期。这个建议再次引发了一直以来对癌症治疗的一个焦点争议和关注：对癌症（恶性肿瘤）该不该进行放射和化学疗法？     

HER2 over-expression and response to different chemotherapy regimens in breast cancer

Purpose To exam the relationship between HER2 over-expression and different adjuvant chemotherapies in breast cancer. Patients and Methods A total of 1625 primary breast cancer patients who received post-surgery adjuvant chemotherapy in Tianjin Cancer Hospital, China, from July 2002 to November 2005 were included in the study. Among them, 600 patients were given CMF (CTX MTX 5-Fu) regimen, 600 given CEF (CTX E-ADM 5-Fu) regimen, and 425 given anthracyclines plus taxanes regimen, with mean follow-up time of 42 months. Results In CMF treatment group, the 3-year disease free survival (DFS)in HER2 over-expressed patients was lower than that of the HER2-negative ones (89.80% vs 91.24%, P=0.0348); in node-positive subgroup, the 3-year DFS was 84.72% in HER2 over-expressed patients, and 90.18% in the HER-2-negative ones (P=0.0271).Compared to CMF regimen, anthracyclines and anthracyclines plus taxanes regimens are more effective (P＜0.05) in node-positive HER2 over-expression than those in the node-negative. Conclusion HER2 over-expression is an independent index for predicting poor prognosis and short DFS for breast cancer patients. HER2 over-expressed patients are resistant to CMF regimen chemotherapy, but sensitive to anthracyclines-based or anthracyclines plus taxanes regimen. HER2 expression can be taken as a marker for therapies in breast cancer.     

A new local ablation for unresectable primary liver tumor： effect of electrothermal and electrochemical therapy on rat liver

Background： Electrochemical therapy （ECT） has been used to treat unresectable hepatic tumor. In order to improve its efficacy, we combined ECT with hyperthermia induced by electrothermal needle （ETN） （ETECT）. The aim of this study is to investigate the destructive effect of ETECT on normal rat liver. Methods： Twenty rats were randomized into 4 treatment groups （n=5 in each group）： control, ECT alone, hyperthermia alone and ETECT. Following the treatment, sections of the livers were histologically examined by light microscopy and the destructive volumes were measured with micrometer. Results： We found that the destructive volumes in ETECT group were the largest （P〈0.01）. In ETECT group coagulative necrosis was found in both anode and cathode areas, around which transition zones existed. The transition zones can only be seen when coulomb was increased in ECT group. Conclusion： ETECT was demonstrated to enhance the destructive effect of ECT. This study provides theoretical and experimental basis for a new local ablative treatment for unresectable primary liver tumor.     

TAX与CTX联合DDP方案治疗卵巢癌的临床疗效分析

目的 了解TP和CP治疗卵巢癌的效果。方法 回顾性分析我院2000年5月“2005年10月收治的40例卵巢癌病例资料。结果 两组疗效及生存率比较有显著性差异。（P〈0．05）。结论 以TAX为主的联合化疗方案对卵巢癌的疗效较好，尤其是对常规治疗后复发的患者。     

606&#183;磺胺&#183;青霉素——病原体的发现及现代化学疗法的发展

1古代疾病观及朴素的“化学疗法”思想 公元130年前后．希腊医生盖伦认为．所有疾病都是人体内部四种体液失调的结果。根据古人的说法,这些体液分别是血液、黏液、胆汁和抑郁液（黑胆汁）。健康人身体中,四种体液达到独特的平衡。四种体液失去平衡即会生病,可以通过放血、发汗、清洗、强迫呕吐等来恢复平衡,治愈疾病。化学史上医药化学阶段最著名的代表人物之一,     

林芝70例肺结核化疗效果分析

对７０例肺结核患者进行全程管理化疗，在管理中以乡医生，病人家属为主体，均按照我科制定的治疗管理合同协议，为病人进行宣传，监督。病人能坚持定期规则服药，完成全疗程的治疗与检查。随该和记录，化疗结果为痰菌阴转率为９２．６６％，空洞闭合率为８０．５６％，治疗有效率为９７．５６％，在９种方案中疗效最显著的是：初治涂阳方案Ⅱ，２Ｅ３Ｈ３Ｒ３Ｚ３／４Ｈ３Ｒ３；初治涂阳方案甲，４Ｈ３Ｉ３Ｌ１／２；复治涂最方案Ｂ