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《安徽教育学院学报》1997,(2)
本研究应用显示乙酰胆碱酯酶(AchE)和生长抑素(SOM)的组织化学和免疫组织化学方法,对扬子鳄结肠壁神经的分布进行了研究。结果表明,呈棕色反应的AchE 阳性神经丰富,分布于结肠壁各层内,AchE 阳性神经元主要分布在粘膜下神经丛,粘膜内可见阳性神经元分布。生长抑素免疫反应(SOM—IR)纤维主要分布在肌层和肌间神经丛,大多为膨体纤维;粘膜下层中 SOM—IR 纤维数量较少,主要分布在小血管壁及周围。肌间神经丛可见 SOM—IR 神经元。表明在低等脊椎动物扬子鳄内脏已存在比较完善的神经调节。 相似文献
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结肠靶向给药体系由于具有直接在结肠部位释放药物及缺乏相关蛋白酶的特点而成为治疗结肠相关疾病及蛋白质类、多肽类药物很好的载体,近年来,其相关研究已取得很大进展,笔者就该制剂的设计进行综述. 相似文献
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结肠腺瘤性息肉病(adenomatous polyosis coli,APC)蛋白是一个大型的多功能蛋白,在发育的大脑皮层中,增殖的细胞可以表达APC,且当细胞向皮层板迁移的时候它的表达会增加.其对于Wnt/β-catenin 信号,细胞骨架动态以及细胞极性十分重要.本文对APC 在大脑皮层早期发育中的作用进行了总结.APC 在大脑皮层早期发育过程中是调节细胞数目,核迁移运动,细胞极性以及细胞类型的特化所必须的. 相似文献
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Ruan WJ Lin J Xu EP Xu FY Ma Y Deng H Huang Q Lv BJ Hu H Cui J Di MJ Dong JK Lai MD 《Journal of Zhejiang University. Science. B》2006,7(11):929-932
Insulin-like growth factor binding-protein-7 (IGFBP7) was obtained from our previous colonic adenocarcinoma (CRC) and normal mucosa suppression subtraction hybridization (SSH) cDNA libraries. By RT-PCR and immunohistochemistry, we found that IGFBP7 was overexpressed in CRC tissue compared to normal tissue. However, our in vitro experiments performed in 10 CRC cell lines showed that IGFBP7 expressed only in SW480 and Caco2 cell lines, which implied an underlying reversible regulatory mechanism. Using methylation-specific PCR (MSP) and bisulfite sodium PCR (BSP), we found that its expression was associated with DNA hypomethylation of exonl. This was further supported by the in vitro study which showed restored IGFBP7 expression after demethylation agent 5-aza-2'-deoxycytidine treatment. Correlation analysis between IGFBP7 expression and prognosis indicated that overexpression of IGFBP7 in CRC tissue correlated with favourable survival. Investigation of the functional role of IGFBP7 through transfection studies showed that IGFBP7 protein could inhibit growth rate, decrease colony formation activity, and induce apoptosis in RKO and SW620 cells, suggesting it a potential tumor suppressor protein in colorectal carcinogenesis. In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1. 相似文献
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目的:观察肠腔清洁有效率,提高插管成功率,缩短结肠灌注时间.方法:将需结肠镜检查行结肠灌注的病人120例,随机分为观察组和对照组,每组60例.对结肠灌注液与结肠灌注方法的改进,观察两组行结肠镜检查时的肠腔清洁有效率,灌注时的插管成功率,灌注所需时间及不良反应发生率.结果:观察组肠腔清洁有效率、插管成功率明显高于对照组(P<0.05),结肠灌注所需时间明显低于对照组(P<0.05),两组不良反应的发生差异无显著性意义(P>0.05).结论:在结肠灌注操作实施过程中方法的改进,提高了肠道清洁度,弥补了单一应用生理盐水灌注时的许多不足,提高了插管插管成功率,缩短结肠灌注时间,无不良反应的发生. 相似文献
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