Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

少年女子柔道运动员一周大运动量训练期间的机能变化

了解一周大运动量训练对少年女子柔道运动员机体代谢和内分泌免疫机能的影响。对少年女子柔道运动员进行1周的大运动量训练,在不同时段测试血清CK、LDH、BUN、T、C和免疫球蛋白等指标。结论为大运动量训练后睾酮、皮质醇、BUN、CK、LDH和白细胞的变化呈现不同变化规律,可以较敏感地反映少年女子柔道运动员训练期的机能状况。     

谷氨酰胺对大强度训练后免疫功能恢复的研究

目的:探讨谷氨酰胺对大强度训练后免疫功能的影响。方法:18名运动员随机分成2组,进行3周大强度训练,训练期间分别补充谷氨酰胺(0.3g/kg wt/d)和安慰剂。采集运动员训练周期开始前1天及最后1天次晨的血液,分别测定血浆谷氨酰胺(Gln)、T淋巴细胞亚群。结果:大强度训练会导致血浆谷氨酰胺水平显著下降(P<0.05),CD4+/CD8+比值降低(P<0.05)。补充谷氨酰胺能维持运动后血浆谷氨酰胺水平和减少大负荷训练对机体免疫平衡的影响。     

急性运动对人体细胞免疫功能的影响

为探讨运动对细胞免疫功能的影响 ,检测了 7名男子田径运动员 1次急性疲劳性运动前和运动后即刻、3h、2 4 h的外周血 T淋巴细胞转化 (TL T)、白细胞介素 - 2 (IL- 2 )活性和皮质醇及胰岛素浓度的变化。结果 :在运动后即刻 ,TL T显著增强 ,IL- 2活性和血浆皮质醇浓度分别略有上升和下降 ;在运动后 3h,前 2项指标和血浆皮质醇浓度分别明显增强和降低。这 3项指标在运动后 2 4 h均恢复到运动前水平。 IL - 2活性变化与皮质醇浓度变化有显著负相关关系。胰岛素在运动前后无明显变化。提示 :1次急性适度运动可提高人体的细胞免疫功能 ,并可持续数 h。这种变化与血浆皮质醇浓度下降有一定关系     

A new approach to explore the knowledge transition path in the evolution of science & technology: From the biology of restriction enzymes to their application in biotechnology

In this contribution, we develop a new approach to explore the process of knowledge transition from discovery-oriented science to technological fields, via applications-oriented research, including a mediator set. This trajectory is referred to as the D-A-T trajectory. It is shown how it can be constructed and measures are proposed to characterize the relational strength among different environments (discovery oriented research, applications-oriented research and patents) and the speed of evolution. Our approach is illustrated by a case study of three fundamental restriction enzymes articles. Among other results we found that 387 patents cited 124 of the 988 articles (a share of 12.55%) in the mediator set. Defining the non-patent references (NPR) transition rate as the number of citing patents divided by the number of articles in the mediator set yields a value 0.392. Our results suggest that the D-A-T path acts as a backbone and reveals important “invisible contributions” of an original scientific work during its evolution from discovery oriented research to outside academia. Our contribution provides a useful tool for bridging the existing gap in detecting the transition of knowledge between science and technology.     

海城尚氏宗谱文化探析

海城尚氏祭祖自清初至今已有三百余年。平南王尚可喜于晚年开始着手编著尚氏宗谱,定祖训,及至尚王逝世,宗祠、陵园逐渐修建,尚氏家族的祭祖仪式逐日发展完善。随着时代的发展,尚氏家祭仪式也有所损益,宗谱文化与社会更加契合融汇,具有了更为广泛的文化内涵。     

论执政党的社会影响力

权力和权威是构成社会影响力的主体要件,凝聚力和吸引力是构成社会影响力的客观要件,不同价值观念与利益关系间碰擅与协调情况决定着社会影响力的实现程度。考察苏东剧变可知,执政地位的共产党之所以失去执政地位,主要原因在于没能实现由革命到建设的角色转换。中国共产党实现了角色转换,具有强大的社会影响力,但还必须按“三个代表”的要求,加强自身建设,正确对待群众、对待权力。     

中国入世对中学英语教学的影响与对策

本文首先初步分析了中国“入世”对中学英语教学环境、英语学习的需求等方面的影响,然后重点讨论了顺应“入世”带来的挑战,改进中学英语教学课堂教学模式、教学內容与教学途径的策略。     

8253定时/计数器方式3计数过程的实验研究

对于我系选用教材和部分参考资料关于8253定时/计数器在方式3的计数过程中表述中所存在的矛盾之处,基于武汉众友电子科技有限公司的接口实验台,提出了一个探究8253计数过程的实验方案。通过分析实验结果,指出了正确的计数过程。     

襄麦冬总黄酮酶法提取的工艺优化

以襄麦冬为原料,通过正交试验,采用酶法提取探讨提取条件对襄麦冬块根中总黄酮类化合物提取的影响.结果表明襄麦冬总黄酮提取最佳的工艺条件为:酶添加量40mg,酶解时间3h,酶解温度50℃,介质pH值为5.0,总黄酮化合物的提取率平均值为0.495 mg/g.