治疗男性支原体尿道炎的疗效观察

目的:比较阿奇霉素与奥复星治疗男性支原体尿道炎疗效,并观察其安全性.方法:108例非淋菌性尿道炎(NGU)男性患者,随机分为2组,阿奇霉素治疗组68例, 奥复星治疗组40例.阿奇霉素治疗组:口服阿奇霉素500mg/d,1次/d;奥复星治疗组:口服奥复星500mg/d, 3次/d.结果:随着疗程延长,总有效率明显提高:阿奇霉素治疗组从83.8%提高到94.1% ,奥复星治疗组从42.6%提高到67.5%;而且阿奇霉素治疗组的有效率明显高于奥复星治疗组(P<0.01).结论:治疗男性支原体尿道炎要有足够疗程,要首选敏感药物阿奇霉素.     

超声乳化溶剂蒸发法制备阿奇霉素超细粉体的研究

采用超声乳化溶剂蒸发法制备了阿奇霉素超细粉体,讨论了溶剂、温度、稳定剂种类及用量、阿奇霉素浓度等对微粉粒径的影响,优化了实验条件.实验结果表明:在最佳实验条件下(丙酮/水为2/3,阿奇霉素质量浓度为16.33g/L,0.667%聚乙二醇6000,温度为25℃),可制备出平均粒径为1.0μm的均匀分散的阿奇霉素超细粉体;红外分析表明本方法未改变样品的化学结构.     

Determination of benzalkonium chloride in viscous ophthalmic drops of azithromycin by high-performance liquid chromatography

A high-performance liquid chromatography (HPLC) system was used in the reversed phase mode for the determination of benzalkonium chloride (BKC) in azithromycin viscous ophthalmic drops. A Venusil-XBP(L)-C_(18) (150 mm×4.6 mm, 5 μm) column was used at 50 ℃. The mobile phase consisted of a mixture of methanol-potassium phosphate (16:5, v/v). Two sample preparation methods were compared. The results suggested that, compared with an extraction procedure, a deproteinization procedure was much quicker and more convenient. Using the deproteinization procedure for sample preparation, calibration curves were linear in the range 5.0～50 μg/ml. The within-day and inter-day coefficients of variation were less than 10%. The average recoveries were determined as 96.70%, 98.52%, and 97.96% at concentrations of 10.0, 30.0, and 50.0 μg/ml, respectively. Variability in precision did not exceed 5%. In conclusion, this HPLC method using a simple sample treatment procedure appears suitable for monitoring BKC content in azithromycin viscous ophthalmic drops.     

高效液相色谱法测定阿奇霉素口服溶液的有关物质

采用高效液相色谱法测定阿奇霉素口服液(Azithromycin Oral Solution)的有关物质.方法:采用Kromsil ODS(4.6 mm×250 mm,5μm)色谱柱,pH 4.0的0.07 mol·L-1磷酸二氢钾-乙腈(2:1)为流动相,检测波长为228 am.结果:该方法灵敏度高,精密度好.结论:本法准确可行,可作为该药的质量控制方法.     

阿奇霉素栓的研制及临床应用

目的:研究阿奇霉素栓的处方、制备工艺、质量控制及临床疗效。方法:以明胶、甘油为基质制备阿奇霉素阴道栓,建立质量控制,并对其进行临床疗效观察。结果:本品制备工艺可行,质量控制能够控制本品的质量,临床疗效可靠。结论:本品制备工艺简单、质量稳定,具有安全、疗效好等优点,适于医院推广使用。     

高效液相色谱法测定阿奇霉素口服溶液的有关物质

采用高效液相色谱法测定阿奇霉素口服液(Azithromycin Oral Solution)的有关物质。采用Kroma-sil ODS(4.6 mm×250 mm,5μm)色谱柱,pH4.0的0.07 mol.L-1磷酸二氢钾-乙腈(2 1)为流动相,检测波长为228 nm。该方法灵敏度高,精密度好。本法准确可行,可作为该药的质量控制方法。