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1.
Karyn Ogata Jones Bryan E. Denham Jeffrey K. Springston 《Journal of Applied Communication Research》2006,34(1):94-113
Drawing on components of agenda-setting theory and the two-step flow of information from mass media to news audiences, this study examines the effects of mass and interpersonal communication on breast cancer screening practices among college- and middle-aged women (n = 284). We theorized that screening behaviors among younger women would be influenced more by interpersonal sources of information while screening among middle-aged women would be more influenced by exposure to mass-mediated information. Findings supported anticipated patterns, revealing important and varying roles for both mass and interpersonal communication in the health behaviors of women. Implications for health practitioners and campaign planners, as well as recommendations for future research, are discussed. 相似文献
2.
目的:探讨热休克蛋白70(HSP70)在人乳腺癌和胃癌中的表达及其意义。方法:应用免疫组织化学的方法对64例乳腺癌和55例胃癌组织中的HSP70进行检测。结果:(1)HSP70在乳腺癌和胃癌组织中的表达分别为78.13%.61.82%。(2)乳腺癌中HSP70的表达与乳腺癌的病理类型.淋巴结转移情况及年龄未发现显著差异(P〉0.05)。(3)胃癌中HSP70的表达与肿瘤浸润深度、淋巴结转移有密切关系(P〈0.05)。结论:HSP70在乳腺癌和胃癌中均呈较高水平表达.其中在胃癌中的表达与肿瘤浸润深度、恶性程度有密切关系,HSP70在乳腺癌和胃癌的发生发展中起重要作用。HSP70可能成为乳腺癌,胃癌的诊断指标之一。 相似文献
3.
[目的]探讨抗增殖核蛋白的单克隆抗体(Ki-67)在肝细胞肝癌(HCC)中的表达情况及临床意义.[方法]采用免疫组织化学方法检测51例HCC病人术后存档的石蜡标本中Ki-67的表达情况.[结果]HCC中Ki-67阳性表达率58.8%.Ki-67表达阳性率与肿瘤大小、门脉癌栓和肿瘤分级相关,与肝硬化、病灶数目、包膜、AFP及HBsAg不相关,Ki-67阳性表达组HCC病人术后无瘤生存期均显著低于阴性表达组.[结论]Ki-67对HCC的浸润转移均起促进作用,是HCC预后的重要标志物. 相似文献
4.
G. N. Raval L. J. Parekh D. D. Patel F. P. Jha R. N. Sainger P. S. Patel 《Indian journal of clinical biochemistry : IJCB》2004,19(2):60-71
Sialic acid, the end moieties of the carbohydrate chains are biologically important and essential for functions of glycoconjugates
and are reported to be altered in cancer patients. Two hundred and twenty five breast cancer (BC) patients, 100 patients with
benign breast disease (BBD) and 100 healthy females (controls) were enrolled for the study. Eight hundred and twenty four
follow-up samples of 225 breast carcinoma patients were also evaluated. The association of sialic acid forms, sialyltransferase
and α-2–6 sialoproteins levels with presence and extent as well as prognosis of breast carcinoma was studied. Serum sialic
acid forms and sialyltransferase revealed significantly elevated levels among untreated breast cancer patients as compared
to the controls, patients with BBD as well as cancer patients in remission. Non-responders showed comparable levels of the
markers with those found in breast cancer patients at the time of diagnosis. Higher levels of sialic acid forms at diagnosis
were associated with poor prognosis. A positive correlation between serum levels of different forms of sialic acids and extent
of malignant disease was observed. The changes in serum proteins with terminal α-2–6 sialic acid correlated well with alterations
in the levels of sialic acid forms and sialyltransferase. Malignant tissues showed elevated levels of sialic acid and sialyltransferase
as compared to surrounding normal tissues.
The results suggested potential utility of these markers in evaluation of clinical outcome. 相似文献
5.
Wang LR Zhang GB Chen J Li J Li MW Xu N Wang Y Shen Tu JZ 《Journal of Zhejiang University. Science. B》2011,12(3):174-179
Objective
To evaluate the predictive values of gene expressions of ribonucleotide reductase M1 (RRM1) and breast cancer susceptibility gene 1 (BRCA1) in peripheral blood from Chinese patients with non-small-cell lung cancer (NSCLC) treated with gemcitabine plus platinum. 相似文献6.
Garima Mehta Seema Kothari P. P. Singh 《Indian journal of clinical biochemistry : IJCB》2001,16(1):65-71
From January 1992-January 1998, 1404 patients attended the “Breast Clinic” of R.N.T. Medical College M.B. Hospital, Udaipur.
Out of these, 11% and 81% patients had breast cancer (B.C.) and benign breast cancer (B.B.D.) respectively. The oxidative
load in B.C. was 2.32 times higher than controls, but comparable to B.B.D. β-Carotene deficiency was uncommon in patients,
whereas vitamin A deficiency was almost equally common in both B.C. and controls. Most of the patients had almost depleted
levels of α-tocopherol and ascorbic acid but their TBAR levels were in normal range. The data in the present study when compared
with B.B.D. and other local normal subjects point out: a) oxidative burden in B.C. is a consequence and not the cause of the
disease, (b) oxidative stress could be one of the etiological factors in tumor expression, which need not to be malignant
and c) α-tocopherol and ascorbic acid are not importantly responsible for higher oxidative burden in B.C. 相似文献
7.
Dash P Pati S Mangaraj M Sahu PK Mohapatra PC 《Indian journal of clinical biochemistry : IJCB》2011,26(2):182-186
Now a days measurement of molecular forms of PSA has gained importance in clinical practice. Several studies have demonstrated
the production of PSA in female tissues, such as breast. The present piece of work has been undertaken with an objective to
estimate the relative proportion of the molecular forms of PSA in serum along with serum testosterone in benign and malignant
breast tumor cases and to analyze their association with the severity of the disease process 34 malignant and 26 benign breast
disease cases along with 33 healthy controls of same age group were enrolled in this study for evaluation. Serum testosterone
was measured by ELISA, whereas serum total PSA (TPSA) and free PSA (FPSA) were estimated by electrochemiluminescence immunoassay.
A significant rise of fasting plasma glucose along with prominent dyslipidemia was observed in breast tumor cases. Marked
rise in serum testosterone as well as TPSA and FPSA was documented in both benign and malignant breast tumor cases. Serum
testosterone revealed a significant positive association with both TPSA and FPSA pointing towards an etiological association
between them. However, surgical removal of tumor mass resulted in a marked decline of presurgical value of both TPSA and FPSA
with a non-significant fall in serum testosterone revealing tumor tissue as the source of FPSA and TPSA. Thus, estimation
of PSA provides prognostic information that may assist in future treatment. 相似文献
8.
Meera S. Ghadge Purva P. Naik Bijaynath P. Tiwari Ruprekha M. Hegde Tanaji J. Matale 《Indian journal of clinical biochemistry : IJCB》2012,27(1):97-99
Breast cancer is one of the most frequent malignancies in the world. Available staging procedures to detect breast cancer
are bone scan, chest X-ray, liver ultrasonography, computerized tomography, estimation of tumor markers like carbohydrate
antigen (CA15-3) and carcino embryonic antigen. These procedures are expensive and may not be required in all cases. Out of
70 patients studied, 55 had normal CA15-3 and 15 had elevated levels of Ca15-3. Eight (14.5%) of the 55 patients with normal
CA15-3 had abnormal bone scan. Fifteen patients had CA15-3 levels above the normal range and among these 9 (60%) had abnormal
bone scan. While prime facie it would appear that a high level of CA15-3 correlate with abnormal bone scan, it is also true
that the numbers are small at present and conclusions about the validity of CA15-3 as marker of bone metastasis may be premature. 相似文献
9.
目的:研究乳腺肿瘤组织印片细胞学检查与组织病理学定性诊断符合率,探讨印片细胞学检查在临床病理学诊断中的应用价值。方法:回顾性分析2004-01—2008-01月采用印片法观察123例新鲜离体乳腺包块,与组织病理切片诊断结果对照分析。结果:总体定性诊断符合率95.93%(118/123),其中恶性肿瘤96.3%,良性肿瘤为95.2%,误诊率为2.44%。结论:组织印片细胞学检查是组织病理学诊断一种有效的补充,也是对术中切除组织筛检定性的一种快捷方法。 相似文献
10.
Hai-yang Wu Li-wei Xu You-yun Zhang Yan-lan Yu Xin-de Li Gong-hui Li 《Journal of Zhejiang University. Science. B》2010,11(5):386-389
Chromophobe renal cell carcinoma(ChRCC) metastatic to the testis has not,to the best of our knowledge,been reported in the literature.Nor have there been reports of delayed bilateral adrenal metastasis of ChRCC.Here we report a case of metachronous contralateral testicular and bilateral adrenal metastasis of ChRCC in a 70-year-old man who underwent right radical nephrectomy for RCC six years ago.He was admitted to the hospital because of left intrascrotal enlargement of two-month duration.Ultrasonography re... 相似文献