Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

欧洲阅读联盟(EURead)推广阅读活动与启示

[目的/意义]欧洲阅读联盟是欧洲社会力量开展阅读活动的母平台，联盟成员所开展的阅读活动既有差异，也有共性，社会影响力大。通过对欧洲阅读联盟成员所办阅读活动及其规律的分析，可为我国公共图书馆主导与开展阅读活动提供借鉴。[方法/过程]概述欧洲阅读联盟，对其成员类型进行解析，并对每一成员的阅读项目进行共性分析，凝练出阅读活动的经验及规律。[结果/结论]我国应建立多级阅读推广力量，建立政府购买阅读服务长效机制，开放图书馆的阅读活动空间，提升阅读活动频率，开发多样化、差异化的阅读活动。     

大学经典推荐书目的遴选标准与发展特点

[目的/意义] 经典阅读处于学生通识教育的核心环节，大学经典推荐书目在"读什么""怎么读"的核心教育环节发挥着重要作用。分析和确立大学经典推荐书目的遴选标准，探究其发展特点，对于优化经典书目编制、推动经典阅读，具有十分重要的意义。[方法/过程] 通过网络调研和电话访谈梳理部分"双一流"高校的官方经典推荐书目，分析我国高校经典推荐书目的产生过程与背景。[结果/结论] 大学经典推荐书目在遴选上重视中国传统经典，也注重借鉴西方经典；人文社会科学经典与自然科学经典遴选相对均衡；发掘元典书目新生，重视充实有价值的影响书目。同时，在阅读推广实践中，呈现出尊重阅读主体、重视首因效应发挥、丰富创新推介载体，以及差异化、层次化、定制化的发展特点，体现出高校党政领导的重视和图书馆的主动作为。     

大学英语精读教学策略

精读课，作为学生学习大学英语的一门重要课程，在学习方法和教材的使用中存在一些问题，作者通过多年的教学经验，对于存在的问题提出了切实可行的改进方法，经过近几年来的不断改进和提高，精读在大学英语教学中发挥着重要作用。     

多维格局的求是精神——评王辉斌教授《李白求是录》

王辉斌教授李白研究力著《李白求是录》出版了,这是近年来李白研究的最新成果。作者从动态型式的整体观照、多元视角的系统思维、宏微互渗的立体态势等多维格局去研究李白,使人窥视到李白学术研究纵深处的许多壶奥,因而此书在还原历史真相的同时又具有方法论的深远意义。     

Using Context Clue in Reading

The context of a word consists of the other words surrounding it and the situation in which it is used.When we come across a new word in our reading,instead of looking it up in a dictionary for its definition,we can guess its meaning from its context.     

浅谈英语考试中的阅读理解

阅读理解是英语考试中的重中之重。本文分析了不同类型阅读理解的具体特征，并给出了解题之法。     

多元智能理论与英语泛读教学

基于多元智能的理论对合班学生进行分组,以组为单位布置课外阅读任务,并利用一节课时间完成检查,展示工作,充分发挥学生的智能优势。     

英语阅读方法对理解能力的影响

良好的速读方法是快速、准确理解短文的重要因素之一。在规定的时间内完成篇幅不等的短文，除相应的词汇量和语法知识外，阅读方法的效率就显得尤其重要。     

浅议图书馆流通部的导读工作

流通部的导读工作有着广阔的服务领域,是联系读者与藏书的桥梁和纽带,是图书馆流通部的核心。