癌胚抗原和核仁组成区蛋白在胃活检良、恶性病变中表达

为探讨癌胚抗原(CEA)和核仁组成区蛋白(AgNOR)在胃粘膜活检中对良、恶性病变的诊断意义,我们取105例标本进行观察。结果表明:CEA和AgNOR计数在单纯性胃炎、肠上皮化生、异型增生和胃癌中表达有关系,其阳性率和计数依次增高。CEA、AgNOR表达有显著性差异。因此,CEA、AgNOR对癌和癌前病变的诊断和治疗具有一定参考意义。     

Gastric motility functional study based on electrical bioimpedance measurements and simultaneous electrogastrography

For some time now, the research on gastric motility and function has fallen behind in the amount of research on gastric endocrine, exocrine secretion, and gastric morphology. In this paper, a noninvasive method to study gastric motility was developed, taking bioimpedance measurements over the gastric area simultaneously with the electrogastrography (EGG). This is based on the concept of observing and analyzing simultaneously the intrinsic electrical gastric activity (basic electric rhythm) and the mechanical gastric activity. Additionally, preliminary clinical studies of healthy subjects and subjects with functional dyspepsia (FD) and gastritis were carried out. The impedance gastric motility (IGM) measurements of the healthy and FD subjects were compared, along with the studies of the FD subjects before treatment and after one week and three weeks of treatment. We also compared IGM measurements of healthy subjects and subjects with erosive gastritis, along with the studies of the subjects with erosive gastritis before treatment and after one week of treatment. Results show that FD subjects have poor gastric motility (P<0.01). After a week of treatment, the gastric motility of FD subjects was not yet improved although the EGG had returned to normal by this time. By three weeks of treatment, the regular IGM rhythm returned in FD subjects. There was a significant difference of IGM parameters between the gastritis and healthy subjects (P<0.05). The EGG rhythm of the gastritis subjects returned to normal at one week post-treatment, while IGM parameters showed a trend to improvement (P>0.05), These results suggest the possibility of clinic application of the proposed method.     

Comparative proteome analysis of Helicobacter pylori clinical strains by two-dimensional gel electrophoresis

Objective  

To investigate the pathogenic properties of Helicobacter pylori by comparing the proteome map of H. pylori clinical strains.     

bcl-2、c-myc在胃癌前病变、胃癌组织中的表达及意义

取胃镜活检标本93例,SP免疫组化法检测bcl-2、c-myc基因蛋白。结果表明bcl-2基因蛋白表达率在伴有上皮异型增生(GED)和肠化生(IM)的慢性浅表性胃炎(CSG)、慢性萎缩性胃炎(CAG)明显高于不伴GED、IM组(P<0.05-0.01)。c-myc表达则差异不明显P1>0.05。GC及伴有GED、IM癌旁粘膜与不伴GED、IM的癌旁粘膜比较,bcl-2与c-myc的表达差异均非常显著(P<0.01)。bcl-2、c-myc共同表达阳性率在CSG、CAG、癌旁粘膜中伴有GED和IM组及胃癌组分别为60.0％、34.8％、54.5％、36.8％。而无GED、IM组均无阳性表达(P<0.05-0.01)。bcl-2、c-myc阳性表达与患者年龄、性别无关(P>0.05)。本文对它们表达的意义进行了讨论。