Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

基于改进遗传算法的图像相关匹配

针对图像匹配的数学特点,设计一种新的改进遗传算法用于相关图像匹配。根据基因位的影响和参数调整策略,采用半确定性和大变异结合,汉明距离控制的方法。仿真结果表明,新算法在收敛性能上大大优于简单遗传算法和经典序列猜测算法。     

BLUP法种猪遗传评定在加拿大

饲养在不同猪群的种猪，其生产性能的原始或校正的背膘和年龄数据是遗传和环境的混合，而我们要选择的是遗传部分而不是其所在饲养的环境。估计育种值(EBVs)是种用猪遗传价值的统计估计值，是猪遗传改良方案中的一种新遗传评定系统。它以猪个体性能和其亲属性能为基础，在其选择决策中考虑母猪或公猪家系，考虑性状的遗传力，群内遗传差异以及品种遗传趋势，然后通过最佳线性无偏预测(BLUP)法来计算出EBVs。加拿大全国运用BLUP动物模型对猪生产成绩(100kg时的背膘和日龄)和母猪生产能力(产仔数)进行日常数据计算机处理后得到种猪遗传评定。种猪遗传改进的现行估计是每年背膘和日龄分别下降了0．35毫米和1．5天，这些进展比1985年应用BLUP法前背膘和日龄的下降快50％和200％。目前，对母猪的生产性状，胴体品质的遗传评定工作也已经着手研究。     

基于遗传算法和BP神经网络的优化设计方法

随着生产规模的复杂化、多维化和非线性等复杂特性的增加，对生产中高效的优化技术要求也越来越迫切，利用并行遗传算法和BP网络的优点，提出采用遗传算法的并行搜索和解空间搜索的优点进行网络参数的选取，利用BP网络简单和可塑性强的优点来优化样本空间，以取得整体的优化效率。     

Hybrid ants-like search algorithms for P2P media streaming distribution in ad hoc networks

Media streaming delivery in wireless ad hoc networks is challenging due to the stringent resource restrictions,po-tential high loss rate and the decentralized architecture. To support long and high-quality streams,one viable approach is that a media stream is partitioned into segments,and then the segments are replicated in a network and served in a peer-to-peer(P2P) fashion. However,the searching strategy for segments is one key problem with the approach. This paper proposes a hybrid ants-like search algorithm(HASA) for P2P media streaming distribution in ad hoc networks. It takes the advantages of random walks and ants-like algorithms for searching in unstructured P2P networks,such as low transmitting latency,less jitter times,and low unnecessary traffic. We quantify the performance of our scheme in terms of response time,jitter times,and network messages for media streaming distribution. Simulation results showed that it can effectively improve the search efficiency for P2P media streaming distribution in ad hoc networks.     

刚性常微分方程的数值解法在化学动力学中的应用

解刚性常微分方程已成为复杂化学反应研究的重要途径，本介绍了化学动力学计算中的刚性问题和数值解法，并着重讨论常用的吉尔(Gear)法和半隐式龙格库塔(Semi-implicit Runge-Kutta)法及其在化学动力学中的应用。     

基于电子商务的精确搜索引擎的研究与实现

随着科技的发展,电子商务日益活跃。现行的电子商务打折网站与生俱来的局限性,越来越跟不上时代的步伐。能否开发一个能够收集全球打折信息的电子商务网站,越来越引起人们的重视。采用精确搜索引擎算法的电子商务精确搜索引擎模型,具有很好的精确性和响应速度,能够查询到精确而全面的打折信息,有较高的实用价值。     

襄麦冬总黄酮酶法提取的工艺优化

以襄麦冬为原料,通过正交试验,采用酶法提取探讨提取条件对襄麦冬块根中总黄酮类化合物提取的影响.结果表明襄麦冬总黄酮提取最佳的工艺条件为:酶添加量40mg,酶解时间3h,酶解温度50℃,介质pH值为5.0,总黄酮化合物的提取率平均值为0.495 mg/g.     

Marcinkiewicz积分交换子在非齐型Herz空间上的有界性

本文主要考虑如下Marcinkiewicz积分交换子在非齐型Herz空间上的有界性Mb(f)(x)=(∫∞0∫x-y≤tK(x,y)b(x)-b(y)f(y)dμ(y)2dt3t)21.     

外国学生副词“又”习得研究

汉语副词的用法及其在句中位置是非常复杂的。＂又＂可分为五大类15种不同的用法。外国学生学习不可能一次习得它所有的用法,要在不同阶段习得。文章利用测试卷让学生在52个句子适当的位置填上＂又＂,根据测试卷计算出外国学生副词＂又＂习得顺序。总结出比较容易习得的＂又＂以及比较难以习得的＂又＂及其结构,提出一些外国学生副词＂又＂的教学建议。