耐力训练对不同鼠龄大鼠血清T、E2、LH和FSH的影响

以不同鼠龄大鼠为研究对象，通过跑台建立大鼠递增负荷的运动模型，探讨耐力训练对不同鼠龄大鼠血清睾酮(T)、雌二醇(E2)、黄体生成素(LH)和促卵泡激素(FSH)的影响。结果认为。1．随年龄增加，大鼠血清T、LH和FSH水平下降，血清E2水平升高。说明，随年龄增加，大鼠性腺分泌功能可能出现下降。2．通过适宜负荷的运动训练可促使大鼠血清T水平显著增加，血清LH和FSH水平增加，血清E2水平下降。说明适宜负荷运动训练可减缓大鼠随年龄增加发生的性腺分泌功能的下降。     

运动与黄体生成素

随着现代竞技运动水平的提高，目前对内分泌激素的研究日益增多，然而报道的大多是运动与性腺激素特别是与睾酮关系的研究，而有关垂体促性腺激素（黄体生成素和促卵泡激素）与运动关系的研究在国内开展较少，本文采用文献资料法，综合目前存在的诸多研究成果，指出不同的运动项目对丘脑—垂体—肾上腺轴功能产生的影响不同，因此就造成了研究结果的巨大差异。     

中药复方制剂"连黄"的传统致畸和致突变试验研究

用昆明种小白鼠对中药复方制剂"连黄"进行了传统致畸试验与致突变试验.结果表明,在传统致畸试验中,对孕鼠的着床数、死胎数、吸收胎数等进行了检查,与对照组比较差异不显著(P>0.05);致突变试验结果表明,小白鼠的微核、精子畸形呈阴性反应,Ames试验也呈阴性反应;结论,中药制剂"连黄"对小鼠无致畸和致突变作用.     

Correlations of Insulin Resistance and Serum Testosterone Levels with LH:FSH Ratio and Oxidative Stress in Women with Functional Ovarian Hyperandrogenism

Functional ovarian hyperandrogenism (FOH) is a form of polycystic ovary syndrome (PCOS) characterized by elevated circulating levels of androgens derived from the ovary. Insulin resistance (IR) is the most common etiological factor in women with FOH. IR causes the generation of increased oxidative stress (OS) and diminished antioxidant status. OS is directly correlated with both IR and testosterone levels, which consequently contribute to endocrine and biochemical alterations in FOH women. In the current study, elevations in total testosterone, free testosterone and luteinizing hormone (LH) levels accompanied by a decrease in follicle stimulating hormone (FSH) level leading to higher LH:FSH ratio were the prominent endocrine changes observed in women with FOH. A significant increase in fasting blood levels of glucose and insulin, as well as an elevated IR were also seen in FOH women, as compared to their age matched controls. Women with FOH have higher pro-oxidant and lower anti-oxidant levels in blood than their age matched controls. In FOH women, elevations in LH:FSH ratio and OS are correlated more with hyperandrogenemia than with IR. Of the androgens, free rather than total testosterone has better positive correlations with elevated LH:FSH ratio and OS, and hence, the former is a better predictive marker for the development of biochemical PCOS in women with FOH.     

间歇性低氧训练对大鼠血清T、C和LH的影响

采用实验法观察间歇性低氧训练对大鼠血清睾酮（T）、皮质醇（C）、T／C比值和黄体生成素（LH）的影响,结果表明：间歇性低氧训练比游泳训练更能促使血清T、T／C比值和血清LH水平的提高,而使C下降更为明显,从而保持高睾酮低皮质醇水平;间歇性低氧训练比游泳训练对大鼠血清激素有更大的影响,暗示其更有利于提高大鼠的运动能力。     

运动应激对HPG轴下丘脑-垂体系统的影响和适应

不同种类运动应激对HPG轴下丘脑-垂体系统产生不同的影响,而机体的HPG轴下丘脑-垂体系统也产生不同的适应性变化,作为反映HPG轴下丘脑-垂体系统功能的代表性指标GnRH、LH和FSH有不同的变化趋势。本文对其变化的趋势及机理进行了探讨。     

Predictors of Insulin Resistance and Metabolic Complications in Polycystic Ovarian Syndrome in an Eastern Indian Population

The purpose of this study was to assess the predictive values of central obesity and hyperandrogenemia in development of insulin resistance and dyslipidemia in the polycystic ovarian syndrome (PCOS) patients in our region. Differences of fasting blood glucose level, insulin resistance index HOMA-IR, lipid parameters, waist hip ratio (WHR), body mass index, LH/FSH ratio and testosterone levels between 45 PCOS cases and 35 age matched controls were obtained. Strength of association between different parameters in the case group was assayed by Pearson’s correlation analysis. Dependence of insulin resistance and WHR on different predictors was assessed by multiple linear regression assay. Total cholesterol, LDL cholesterol, LH, FSH, LH/FSH ratio, WHR and insulin resistance were significantly higher in the case group (p < 0.05). Serum testosterone showed strong correlation with insulin resistance and LH/FSH ratio (r = 0.432 and 0.747, p = 0.01 and 0.001 respectively) in the PCOS patients while WHR and serum testosterone level stood out to be most significant predictors for the insulin resistance (β = 0.361 and 0.498; p = 0.048 and 0.049 respectively). Hyperandrogenemia and central obesity were the major factors predicting development of insulin resistance and its related metabolic and cardiovascular complications in our PCOS patients. We suggest early monitoring for androgen level and WHR in these patients for predicting an ensuing insulin resistance and modulating the treatment procedure accordingly to minimise future cardiovascular risks.     

Evaluation of FSH,LH and testosterone levels in different subgroups of infertile males

Gonadotropins (FSH, LH) and testosterone are the prime regulators of germ cell development. Abnormal spermatogenesis is often associated with altered serum gonadotropins and testosterone. FSH, LH and testosterone levels were estimated in 96 infertile men of whom 35 were azoospermic, 35 were oligozoospermic, 11 were with varicocele and 15 were with histopathological abnormalities like hypospermatogenesis, spermatid arrest and sertoli-cell only syndrome. Results showed statistically significant (p<0.05), increase in the mean FSH and LH levels in all the infertile males studied when compared with the fertile controls (n=35). However, there is no significant difference in the mean levels of testosterone between the infertile and fertile men.     

中等强度训练对运动员基础分泌的影响

对10名有系统训练的国家一级运动员采用中等强度训练和10名无系统训练普通男大学生在基础状态下，血浆心钠素、血清皮质醇（C）、卵泡刺激素（FSH）、睾酮（T）、黄体生成素（LH）和生长激素（GH）的变化进行对比研究。测试结果：训练组的血清T和T／C比值明显高于对照组（P〈0．05），其他指标无显著性差异（P〉0．05）。结果表明，中等强度的运动训练对机体血清T和T／C比值的基础分泌有一定影响，并对运动成绩的提高有利。     

大鼠一次性力竭运动后血浆睾酮的变化及变化机制

用大鼠作为实验对象,观察一次性力竭运动对血浆睾酮的影响;同时对这种形式下运动对血浆睾酮的变化机制作了初步探讨。发现一次性力竭运动后血浆睾酮显著下降,但黄体生成素变化不大。用肾上腺素胸腔注射使大鼠心率持续升高1h,血浆睾酮无显著性变化。大鼠进行1h 力竭性运动时,下丘脑—腺垂体轴的功能及睾酮代谢廓清率变化不大。血浆睾酮的下降可能与运动时睾丸分泌机能下降有关。