Fabrication of microcapsule arrays on chemically patterned surfaces via covalent linking

A method for fabricating arrays of microcapsules covalently immobilized onto chemically patterned substrates was developed. The core-shell microparticles with poly（allylamine hydrochloride） （PAH） as the outermost layer were obtained by layer-by-layer （LbL） assembly, which were further treated with glutaraldehyde to endow the particles with abundant aldehyde groups on their surfaces. The particles were then covalently coupled to the chemically patterned regions with amino groups created by microcontact printing （μCP）. After dissolution of the core particles, arrays of the hollow microcapsules with unchanged structures were obtained. These arrays could stand rigorous environmental conditions of higher ionic strength, and lower and higher pH values. Thus, the technique could be possibly applied to exploiting chips of microcontainers or microreactors in sensing technology.     

复凝聚法制备滁菊挥发油微囊的工艺研究

探索滁菊挥发油微囊的最佳制备工艺。采用复凝聚法制备滁菊挥发油微囊,以外观形态、粒径、包封率、载药量为指标,正交设计优选工艺条件。滁菊挥发油微囊的最佳制备工艺条件为:复合胶与挥发油的比例为1∶1,温度为55℃,p H为4.0,固化剂量为1.5m L。制得的滁菊挥发油微囊形态呈圆形、光滑,粒径分布在80~120μm,平均包封率为(48.89±5.93)%,平均载药量为(13.11±2.30)%,TLC法显示供试品溶液与对照品溶液在相同的位置出现相同斑点。该制备方法操作简单易行,处方合理,制得微囊外观圆整,载药量和包封率较高。