视交叉与蝶鞍关系的临床解剖学研究

目的:研究视交叉的解剖特点,进而为垂体肿瘤切除手术提供解剖学依据.方法:在20例成年男性头部标本上,对视交叉进行观察与测量.结果:视交叉前缘与鞍结节相距4.42±1.17mm,视交叉前缘与交叉前沟相距7.0±1.1mm,视交叉与镰状韧带颅前窝附着处后缘相距10.7±1.02mm,视交叉宽度为10.6±1.2mm,在出视神经管、入颅处,两侧视神经内缘相距14.8±1.9mm.结论:视交叉的解剖关系是垂体瘤手术成功与否的关键.     

Relationship between the size of pontocerebellar angle tumor and audiology

Objective: To study the relationship between the size of pontocerebellar angle tumor and audiology. Methods: Retrospective analysis of accoustically evoked brainstem response (ABR) waveforms and pure tone threshold in 27 subjects with tumor of pontocerebellar angle. Results: ABR wave forms and pure tone threshold were significantly affected statistically by the size of tumors, especially those tumor larger than 3 cm in diameter. Conclusion: The primary symptom of the patient was unilateral hearing loss. Early discovery of the lesion is important and ABR is a sensitive tool for early diagnose of the tumor.     

雄黄抗MFC小鼠肿瘤的实验研究

目的:探讨雄黄对小鼠胃癌细胞株M FC的抑制作用.方法:采用小鼠腋下接种肿瘤细胞悬液,再给予剂量为6.5mg/10g的雄黄液灌胃,观察肿瘤生长变化.结果:雄黄对MFC的抑瘤率为65.4%.结论:雄黄对MFC的生长具有明显的抑制作用.     

DNA甲基化异常与肿瘤发生的研究

DNA甲基化是真核生物DNA的正常内源性修饰方式 ,它由DNA甲基化转移酶催化发生。但DNA甲基化异常在肿瘤发生中却起着极为重要的作用 ,它主要表现为抑癌基因高甲基化所致的基因失活和原癌基因低甲基化所致的基因激活 ,引起与细胞增殖、分化相关基因表达异常 ,造成细胞恶变形成肿瘤。文章总结了DNA甲基化异常对肿瘤相关基因表达的影响 ,在肿瘤发生中的可能机制及针对高甲基化的治疗方案     

皮肤镜在卓越医师班皮肤肿瘤教学中的应用评估

探讨皮肤镜技术结合PBL教学法在卓越班皮肤性病学教学应用中的意义.以本校2015级卓越班40人为实验组,采用皮肤镜技术结合PBL教学法;随机选取2015级临床医本班40人为对照组,采用传统教学法.选择皮肤肿瘤章节,两组为同一教师授课及带教,教学结束后进行对比性研究.教学结束时,实验组与对照组考核成绩相比较具有统计学意义...     

Spontaneous Tumor Lysis Syndrome in an Infant: A Case Report

Tumor lysis syndrome has been observed in patients with malignancies with high cellular burden and high cell turnover, tumor sensitive to therapy, especially after initiating medical treatment. It very rarely occurs spontaneously. The case described here is of 6 months male infant who presented with fever since 1 month and loose stools associated with blood since 15 days. The laboratory investigations showed lactate dehydrogenase (LDH) of 6,192 IU/L and serum uric acid 18.2 mg/dl along with pancytopenia. The infant presented with electrolyte abnormalities and renal failure.     

SIRTUIN1介导的NIH3T3成纤维细胞昼夜节律时钟基因表达抑制的光生物调节作用

背景和目的:昼夜节律是影响运动成绩的一个重要因素。研究发现,介导运动应激的肿瘤坏死因子(tumor necrosis factor,TNF)能够抑制昼夜节律时钟基因的表达。研究了低强度810nm激光(low intensity 810 nm laserir radiation,LIL)对TNF抑制效应的调节作用。材料和方法:50%马血清休克处理NIH3T3成纤维细胞2h,同步化昼夜节律时钟基因的表达后,加入10ng/mL TNF-alpha抑制它的表达,与此同时给予20min10mW/cm2的LIL照射。36h内,每隔6h检测细胞中时钟基因Clock、Bmal1、Per2、Dbp和烟酰胺腺嘌呤二核苷酸辅酶(nicotinamide adenine dinucleotide,NAD+)依赖的组蛋白去乙酰化酶1(sirtuin1,Sirt1)的mRNA的表达及胞内NAD+和其还原形式NADH的比值NAD+/NADH。结果:TNF-alpha分别在第12h和第18h抑制了Clock(P<0.05)、第18h抑制了Bmall(P<0.05)和Dbp(P<0.005)、第18h和第30h抑制了Per2(P<0.05)及...     

Deregulation of microRNA expression in thyroid tumors简

MicroRNAs (miRNAs or miRs) are endogenous non-coding RNAs that negatively regulate gene expression by binding to the 3′ non-coding regions of target mRNAs, resulting in their cleavage or blocking their translation. miRNAs may have an impact on cell differentiation, proliferation, and survival, and their deregulation can be inclined to diseases and cancers, including thyroid tumors. The purpose of this review is to summarize the existing findings of deregulated miRNAs in different types of thyroid tumors and to exhibit their potential target genes, especially to demonstrate those involved in tumor invasion and metastasis. In addition, new findings of circulating miRNA expression profiles, single nucleotide polymorphism (SNP) in thyroid tumors, and the correlation of somatic mutations with deregulated miRNA expression in thyroid tumors were all included in this review.     

自噬与肿瘤

自噬作为一种细胞防御和应激调控的机制,目前成为癌症研究领域的又一热点。在不同种类的肿瘤以及肿瘤发生发展的不同阶段,自噬有抑制和促进两种对立的影响。自噬异常与恶性肿瘤的能量代谢、细胞死亡、炎症反应以及对肿瘤治疗的耐药性等方面都有密切的联系。全面正确地了解自噬可为肿瘤治疗提供一个崭新的思路。