Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

帆板实际航行中运动学参数的测定

对帆板运动进行三维解析即可有效地分析运动员的操作技能，也可利用测定的运动学参数反过来计算与检验空气动力学参数与水动力学参数。介绍了帆板运动的运动学参数、测定的方法。分析了帆板运动学参数测试的可行性。     

园林景观动画设计初探

本文通过对计算机三维动画的相关理论与技术的初步探讨，并结合环境景观动画的制作实例，介绍了该技术在园林景观动画设计方面的应用和发展前景。     

试论普通话教学中的心理素质培养

试从学习动机、情感因素、心理调控等方面,论述普通话教学中心理素质培养的重要性及具体举措。     

中国北方汉族青年ACE 基因I/ D多态性频率分布特征

通过分析与探讨汉族普通人群ACE基因I／D多态频率分布特征，试图为中国优秀耐力运动员的基因选材研究提供中国人相关人群ACE基因I／D多态频率分布的基础数据。选择18-22岁汉族学生216名作为研究对象，观察其ACE基因I／D多态频率分布。结果显示：北方汉族青年的ACE基因I／D多态频率分布，与国内相关研究结果一致，与欧美人群有非常显著差异。研究认为：从种族单一性、样本数量和年龄段的选择等因素考虑．研究结果不仅可以作为北方汉族青年ACE基因I／D多态频率分布的代表，而且对于杰出耐力的多态性标记研究来讲是理想的对照群体。     

高职《Delphi程序设计》教学模式初探

本文旨在探讨《Delphi程序设计》课程如何改变传统以程序语言自身的体系为脉络展开的教学模式,借鉴企业工程开发流程展开教学,再结合项目式教学法,四阶段教学法、启发式教学法与分层次教学等多种教学策略的综合运用,将理论知识点与专业技能综合在一起,提升学生的综合职业能力,从而缩小人才培养与社会需求的差距。     

三维模型库的参数化建模

文章探讨了用SolidEdge软件参数化快速建模,从而大大加快了建立三维模型库的速度,三维模型库可用于多媒体教学.     

高校图书馆建设的系统工程观

按《普通高等学校图书馆规程》条款，高校图书馆建设具有系统工程属性，强化服务职能是建设的重心，服务质量是评估的依据。四川高校图书馆应面对知识经济和社会发展，拓宽教育与信息服务职能，共建西部大开发的文献信息保障体系。     

提高编制水平 有效控制工程造价

提高工程造价编制水平,必须改变现有的计价模式。工程造价只有贯穿于建设项目的全过程才能得到合理确定。