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Basic fibroblast growth factor alleviates brain injury following global ischemia reperfusion in rabbits 总被引:9,自引:0,他引:9
Zhang M Ma YF Gan JX Jiang GY Xu SX Tao XL Hong A Li JK 《Journal of Zhejiang University. Science. B》2005,6(7):637-643
The aim of this study was to explore the protective effect of basic fibroblast growth factor (bFGF) on brain injury following global ischemia reperfusion and its mechanisms. Brain injury following global ischemia was induced by four vessels occlusion and systemic hypotension. Twenty-four rabbits were randomized into three groups: group A, only dissection of vessels; group B, intravenous infusion of normal saline after reperfusion for 6 h; group C, 30 μg/kg bFGF injected intravenously at the onset of reperfusion, then infused with 10 μg/(kg·h) for 6 h. Serum neuron specific enolase (NSE), S-100B, tumor necrosis factor-α(TNF-α), interleukin-1 (IL-1), interleukin-8 (IL-8) were measured before ischemia, 30 min after ischemia, 0.5, 1, 3, 6 h after reperfusion. Brain water content was determined and cerebral histopathological damages were compared. NSE and S-100B were increased 1 h after reperfusion and reached their peaks 6 h after reperfusion, but were much higher in group B than those in group C 3, 6 h after reperfusion. In groups B and C, TNF-a was increased after ischemia and IL-1 and IL-8 were increased significantly 0.5 h after reperfusion, then reached their peaks 6 h, 3 h, 6 h after reperfusion respectively. TNF-a and IL-8 at the time points of 1 h and 3 h and IL-1 at 3 h and 6 h in group C were correspondingly lower than those in group B. These indices in group A were nearly unchanged. There were less severe cerebral histopathological damages in group C compared with group B, but no difference in brain water content. It could be concluded that bFGF alleviates brain injury following global ischemia and reperfusion by down-regulating expression of inflammatory factors and inhibiting their activities. 相似文献
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Montgomery multiplication over rings 总被引:1,自引:0,他引:1
Montgomery multiplication of two elements a and b of a finite field Fq is defined as abr-1 where r is a fixed field element in . In this paper we define Montgomery multiplication of elements a(x) and b(x) in a polynomial ring modulo the ideal generated by a reducible polynomial f(x). We then show that Montgomery multiplication over a field represented by a polynomial ring modulo an irreducible pentanomial can be performed more efficiently in terms of time delay by embedding the field in a quotient of a polynomial ring modulo a reducible trinomial. The trinomial has a degree that is slightly higher than that of the pentanomial, thereby increasing the number of gates in the multiplier by a small amount. 相似文献
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以了解学生对在线学习之使用情况,与使用学生自行拟定测验题题库的适当性与否为目标,采用课堂学习搭配在线学习作为课程学习的方式,且由每位学生自行拟定课程最后阶段的测验试题,探讨学生的学习态度、适应情况与此教学策略是否合宜。用S-P表分析等研究表明,在此整个学习过程中,学生的学习态度从被动学习转换成了主动学习,学生对于将传统的课堂教学搭配在线学习的方式感到新奇,对于平时少数有缺课的同学亦可利用在线学习的平台将其在课堂上的不足加以弥补,整体对于学习情况为提升且有成效的。 相似文献
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李永良 《中国现代教育装备》2007,(10):13-15
S-4800是目前场发射扫描电子显微镜中的高端产品,其独特的电子光学设计使得该仪器在获得二次电子(SE)图像的同时,还能在图像中掺入不同比例的背散射(BSE)信号,以获得二次电子和背散射(SE BSE)的复合图像,背散射信号的加入,既能减轻图像的荷电效应,又能增加图像的成分信息,对分析导电性差的样品,以及不同相的样品提供了方便。 相似文献
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1 IntroductionThe derivation of invariants-also refered toas conserved quantities or constants of motion-is a key objective studying analytically a givensystem.If we succeed to isolate an invariant,wealways learn about a fundamental system prop-erty.The m… 相似文献
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周格 《郧阳师范高等专科学校学报》2014,(3):33-36
分析数字海图的VPF格式和S-57格式的特点,及两种格式的物标和属性定义的关系与差异,从VPF格式向S-57格式转换的处理流程,到建立数据编码对照关系的各种方法:直接对应、拆分、合并、重构等各种方法,建立数据从VPF到S-57的编码对照关联,完成海图数据从VPF格式向S-57格式的转换. 相似文献
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近些年来,集资诈骗和非法吸收公众存款等非法集资活动多有发生。此类活动,一旦投资人的资金无法获得偿还,将会引发严重的社会不稳定。同时,大量社会资金循环于金融机构之外,将会严重干扰我国的金融秩序,不利于经济的稳定。对该类违法犯罪行为既要严惩,更要采取有效措施加大防范力度。 相似文献
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王洪 《佳木斯教育学院学报》2012,(9):399-399
随着人权运动以人为本思想的确立和公民法律意识的增强,越来越多的案例中涉及到精神损害赔偿的问题,而我国法学界对精神损害赔偿的理论研究尚处在初级阶段,致使长期以来,我国民事法律对精神损害赔偿的适用范围规定得过于狭窄,不足以维护人身权利;对赔偿的数额标准也没有明确、具体的规定。本文着重探讨了精神损害赔偿在适用范围和数额确定上的立法缺陷,并就这两个问题发表一些个人的看法和意见。 相似文献