Takayasu’s arteritis associated with Crohn’s disease

Takayasu’s arteritis (TA), also known as the “pulseless disease,” is a chronic vasculitis of the aorta and aortic branches. TA with Crohn’s disease is rare and has not been documented in China before. In this paper we report on a case of Takayasu’s arteritis associated with concurrent Crohn’s disease. A 17-year-old Chinese male developed upper limb sourness and a sensation of fatigue, and his upper limb pulses were absent. He was diagnosed with TA and underwent an axillary artery bypass with autologous great saphenous vein on the left subclavian artery. After the surgery, he regained the normal blood pressure. This patient also had years of diarrhea and developed an anal canal ulcer, and was diagnosed with inflammatory bowel disease and ulcerative colitis before. Five months after the TA surgery, he was hospitalized for severe stomachache and diarrhea and was finally diagnosed with Crohn’s disease. The possible pathophysiological mechanisms responsible for concurrent existence of TA and Crohn’s disease may be associated with immune disorders, especially autoimmunity.      

Case Report: Takayasu's arteritis associated with Crohn's disease

Takayasu's arteritis (TA), also known as the "pulseless disease," is a chronic vasculitis of the aorta and aortic branches. TA with Crohn's disease is rare and has not been documented in China before. In this paper we report on a case of Takayasu's arteritis associated with concurrent Crohn's disease. A 17-year-old Chinese male developed upper limb sourness and a sensation of fatigue, and his upper limb pulses were absent. He was diagnosed with TA and underwent an axillary artery bypass with autolo-gous great saphenous vein on the left subclavian artery. After the surgery, he regained the normal blood pressure. This patient also had years of diarrhea and developed an anal canal ulcer, and was diagnosed with inflammatory bowel disease and ulcerative colitis before. Five months after the TA surgery, he was hospitalized for severe stomachache and diarrhea and was finally diagnosed with Crohn's disease. The possible pathophysiological mechanisms responsible for concurrent existence of TA and Crohn's disease may be associated with immune disorders, especially autoimmunity.     

多发性大动脉炎诊治分析

目的观察糖皮质激素联合免疫抑制剂治疗多发性大动脉炎疗效。方法回顾性分析襄阳市襄州区人民医院收治的6例多发性大动脉炎诊断治疗情况。结果 2例病情缓解,包括临床症状缓解或消失,ESR和CRP恢复正常,病情缓解后激素减量维持;1例出现病情复发,复发后联合细胞毒药物及激素治疗,糖皮质激素自始起量开始,病情得到控制;3例患者动脉狭窄严重的行介入治疗后给予小剂量激素维持治疗。结论多发性大动脉炎由于病因不明,早期无特异性症状,早期诊断较困难;确诊后,用糖皮质激素联合免疫抑制剂治疗,对于无严重动脉狭窄的患者能较好地改善症状。