Motilin levels and electrogastroenterogram studies in hypothyroidism

To study the relationship between gastrointestinal dysfunction and motilin in patients with hypothyroidism. The plasma motilin concentration was measured by radiommunoassay (RIA) in 30 patients with hypothyroidism and also in 30 controls. At the same time, the electrogastroenterogram was also taken. Among the hypothyroidism patients, 56.6% had decreased gastric motility, especially in gastric body and greater gastric curvature; 86.6% had decreased colonic motility, especially in the left half of the colon. There were no significant differences of plasma motilin concentration between patients with hypothyroidism and controls (P>0.05). There were also no differences between pre-treatment and post-treatment individuals, but significant differences were observed in the electrogastroenterogram. We conclude that the plasma motilin concertration in hypothyroidism patients was the same as that in normal patients, and that electrogastroenterogram studies in patients with gastrointestinal dysfunction may be valuable.     

汉中地区109例先天性聋哑病患者的群体遗传学研究

通过群体调查,证实先天性聋哑病的遗传方式表现为常染色体隐性遗传,且外显完全,并有遗传异质性、表型模拟等特点.讨论了先天性聋哑的遗传咨询和优生原则.     

三要素法的适用对象

指出三要素适用对象是电容电压或电感电流，而一些献对此有所误解。     

语言理解及表达力先天发育水平表现因素研究

为了最大限度减少后天因素对语言理解及表达力先天发育水平的影响,以3岁幼儿为研究对象,在分析现有对语言理解及表达力研究的基础上,提出语言理解及表达力表现因素测评指标框架,依据其共性表现因素并结合3岁幼儿语言理解及表达力的个性表现,进行了测评指标实验研究。对西安地区不同水平幼儿园随机抽样的297名儿童进行测评,结果表明这种测评方法具有普适性与可操作性。     

Functional characterization of an invertase inhibitor gene involved in sucrose metabolism in tomato fruit

In this study, we produced tomato plants overexpressing an invertase inhibitor gene (Sly-INH) from tomato, using a simple and efficient transient transformation system. Compared with control plants, the expression of Sly-INH was highly upregulated in Sly-INH overexpressing plants, as indicated by real-time polymerase chain reaction (PCR). Physiological analysis revealed that Sly-INH inhibited the activity of cell wall invertase (CWIN), which increased sugar accumulation in tomato fruit. Furthermore, Sly-INH mediated sucrose metabolism by regulating CWIN activity. Our results suggest that invertase activity is potentially regulated by the Sly-INH inhibitor at the post-translational level, and they demonstrate that the transient transformation system is an effective method for determining the functions of genes in tomato.     

瞬变电磁测深在小秦岭大湖金钼矿床深部找矿中的应用

大湖金矿位于小秦岭金矿田北矿带的东部,是小秦岭地区一个大型石英脉型金、钼矿床,目前主要勘探中深部矿产资源。本文结合矿区地质、地球物理特征,在其所判定的成矿远景区,开展了瞬变电磁测深法找矿工作,圈定电性异常体,指导钻探工程的布设,取得了较好的找矿效果,对小秦岭其它地区深部勘探工作具有一定的参考价值。     

Are hsCRP Levels and LDL/HDL Ratio Better and Early Markers to Unmask Onset of Dyslipidemia and Inflammation in Asymptomatic Subclinical Hypothyroidism?

The implications of subclinical hypothyroidism (SCH) are many amongst which the most important is progression to overt hypothyroidism. Other debatable aspects are its association with cardiovascular risk, neuromuscular and psychiatric dysfunction, increased predisposition to developing metabolic syndrome and an underlying pro-inflammatory state. We aimed to study the lipid profile, lipoprotein(a) [Lp(a)] and hsCRP levels and insulin resistance in a group of patients with SCH in a referral hospital and see if any significant differences exist between them and euthyroids. This is a case–control study where the selection of controls and cases was based on the thyroid profile. Subjects were selected on their visit to clinical biochemistry lab for thyroid function tests. 33 euthyroids were taken as controls (Group I) and 38 patients comprising of subclinical hypothyroids were grouped as cases (Group II). Serum thyroid stimulating hormone (TSH) was in the range of 0.5–5.0 mIU/L for euthyroids and for subclinical hypothyroids the concentration of TSH was more than 5 mIU/L. The concentration of tri-iodothyronine (T₃) and thyroxine (T₄) were in normal reference range in both the groups. Individual lipid profile parameters failed to show a significant p value between cases and controls. The LDL/HDL ratio was highly significant (p value < 0.0001) and hsCRP was also statistically between the two groups (p value = 0.0054). Lp(a) and insulin resistance did not differ significantly. SCH is a common disorder that frequently progresses to overt hypothyroidism. This study underlines the importance of LDL/HDL ratio rather than measurement of individual lipid profile parameters in bringing to light the dyslipidemic state associated with SCH. Moreover the use of hsCRP to detect an underlying pro-inflammatory state in SCH can also be emphasized.     

Learning on the go: voices of highly mobile urban students

Highly mobile students experience schools and learning in different ways than their more stable peers. Repeated transfers result in discontinuity of instruction and relationships with teachers and peers. Interviews with transient urban students in grades 9–12 reveal the issues they face upon their arrival and afterward. Mobile students give insight into perceptions of teacher practice, peer-group induction, receptivity to classroom instruction, and classroom and administrative practices. Findings include fear, loneliness, embarrassment, and anxiety in new settings or when faced with another school change. While students expressed achievement concerns, peer social and emotional concerns were primary immediately following enrollment in a new school. Students found themselves unable to focus on academic studies until they could secure a peer group with which to interact. Implications for high-mobility schools include the need for structures providing transitional services and community-building environments to counteract the negative academic and developmental effects of frequent mobility.     

单纯性先天上睑下垂一家系5代20例的调查研究

调查单纯性先天上睑下垂一家系5代20例．通过系谱分析,认定该病为常染色体显性遗传．因基因突变而引起提上睑肌功能不全所致,需通过整形手术而矫正．     

Intervening to Improve Teachers’ Need-supportive Behaviour Using Self-Determination Theory: Its Effects on Teachers and on the Motivation of Students with Deafblindness

Research on Self-Determination Theory has shown that teachers’ need-supportive behaviour is associated with student motivation and engagement. The purpose of this study is to examine the effectiveness of an intervention aimed at increasing the motivation of students with congenital and acquired deafblindness by enhancing teachers’ need-supportive behaviour. To assess the intervention effect, this study follows a multiple case-study design. Teacher questionnaires were administered and video observations of teacher–student interactions were made during pre-test, post-test and follow-up phases. The results showed that teachers provided involvement most, followed by structure and autonomy support. Teachers’ provision of structure and autonomy seems to improve most after the intervention. In general, teachers of students with congenital deafblindness showed larger intervention effects than teachers of students with acquired deafblindness. The results also provide indications that students’ levels of engagement improved after the intervention.