Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

对民国档案文件级整理工作的思索

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。     

COUNTER R5的新特性及对图书馆的影响

COUNTER是规范网络化电子资源使用统计报告数据处理、审核和提交的国际化标准,是图书馆电子资源使用量统计和评估的核心要素。目前COUNTER已经发布了最新版本R5,了解R5的新特性及与之前版本的不同对于图书馆的电子资源统计工作具有重要意义。本文拟从COUNTERR5的报告设置、报告的指标类型、数据类型、访问类型和其他完善报告的属性来解析R5,同时介绍R5对SUSHI收割的影响、"持续维护"的概念、R5发布对图书馆的影响和R5实施的重要时间节点,同时也对R5较之R4的发展和不同进行了比较和分析。COUNTERR5的主要关注点是一致性、清晰性和简单性,较之COUNTERR4有了明显的完善,同时包含了持续的维护过程,允许对代码进行更新而不必再引入一个全新的版本,解决了版本升级会对供应商和图书馆带来的各种时间和人员成本的影响。     

The Human Rights Approach to Education in International Organisations

In this article, the work of three international governmental organisations (IGOs) dealing with human rights will be discussed, namely the United Nations Educational, Scientific and Cultural Organization (UNESCO), the United Nations Children's Fund (UNICEF)¹ and the Council of Europe (CoE). In the first section, the main characteristics of the three IGOs in terms of similarities and differences will be elaborated. Then, their human rights approach to education will be described, dealing with the legal foundations. In the final section, the different strategies of implementation based on both their official mission statements and their present strategy papers will be evaluated under the heading ‘competition vs. cooperation’.     

光谱吸收式光纤气体传感器分辨率研究

气体传感器在环境检测、火灾与安全报警系统以及食品化工中具有广泛应用。分析了吸收式气体传感器的工作数学模型与光电检测电路的结构特点,探讨了提高吸收式光纤气体传感器分辨率的方法。     

社鼠、雷琼社鼠和针毛鼠染色体分类的研究

社鼠、雷琼社鼠和针毛鼠都是山地栖息种类，它们染色体的2n数目和形态明显有别于同属的其他各种．体现出它们之间的亲缘关系较近，它们间的核型演化是通过罗伯逊易位和缺失途径，社鼠、雷琼社鼠和针毛鼠有着不同于属中其他种类的生态位，把它们另作一属会恰当些；社鼠和雷琼社鼠的地理分布有所不同．但染色体组型并不差异．认为它们间可能仅是毛色变异，而不存在两个亚种之分．     

用常量仪器进行半微量化学分析实验的研究

本从培养学生技能、降低实验开支、减少环境污染的角度出发，围绕常量仪器进行半微量化学分析实验进行研究。     

基于Web Services的构架及企业应用

随着互联网的不断发展，企业对跨平台的系统需求越来越迫切，而新的网络应用技术构架Web Services技术的出现，为企业应用集成的发展提供了崭新的模式．通过介绍Web Services的主要技术及其应用构架，并结合具体的实例阐述了Web Services构架技术在企业上的应用及前景．     

墨子思想与中国和谐社会建设

中国先秦思想家墨子设计了一个“爱无差等”的和谐社会图画。由于历史条件的局限性,他所构造的和谐社会没能出现,但他主张的“兼爱”、“非攻”、“节用”思想,给21世纪中国和谐社会的建设提供了丰富的思想文化资源。本文从墨子“兼爱”、“非攻”、“节用”思想出发探讨了如何建设中国特色的和谐社会。