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花椒挥发油与其主要成分经皮促透作用的比较研究 总被引:3,自引:0,他引:3
Yi LAN Hui LI Yan-yan CHEN Ye-wen ZHANG Na LIU Qing ZHANG Qing WU 《Journal of Zhejiang University. Science. B》2014,15(11):940-952
研究目的:比较花椒挥发油与其主要成分作为经皮促透剂的皮肤细胞毒性,对系列不同油水分配系数药物促透作用特征及其作用机制。
创新要点:选择系列不同油水分配系数中药活性成分简化并表征中药制剂中复杂有效成分,对比研究花椒挥发油与其主要成分的经皮促透作用特征差异。
研究方法:利用表皮角质形成细胞(HaCaT)和真皮成纤维细胞(CCC-.ESF-1)测定其皮肤细胞毒性,选择系列不同油水分配系数中药活性成分作为模型药物测定花椒挥发油与其主要成分的经皮促透作用特征差异,并在此基础上采用傅利叶变换红外光谱(FTIR)等研究其促透作用机制。
重要结论:花椒挥发油相对于其单一组成成分具有更好的经皮促透效果。 相似文献
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2008—2009年对毕节市的花椒害虫进行了初步的调查,发现直接危害花椒的害虫6目20科39种,主要有棉蚜、花椒桑拟轮蚧、花椒凤蝶、蓝桔潜跳甲等,种类调查旨在为进一步对主要害虫的生物学研究和防治技术研究做一个基础工作。 相似文献
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目的:观察复方两面针通络散外敷治疗神经根型颈椎病的临床疗效。方法:采用回顾性分析的方法,对广西中医药大学第一附属医院2014年6月至2015年6月收治的100例神经根型颈椎病患者,随机分成2组,对照组50例采用常规手法及针刺进行治疗,治疗组50例在对照组手法针刺治疗的基础上应用复方两面针通络散外敷。结果对照组有效率为92%,治疗组有效率100%,2组疗效分析,差异具有统计学意义。结论:复方两面针通络散外敷治疗神经根型颈椎病有较好疗效。 相似文献
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Cytotoxicity and enhancement activity of essential oil from Zanthoxylum bungeanum Maxim. as a natural transdermal penetration enhancer简 总被引:2,自引:0,他引:2
Yi Lan Qing Wu Ying-qiu Mao Qiong Wang Jing An Yan-yan Chen Wen-ping Wang Bo-chen Zhao Na Liu Ye-wen Zhang 《Journal of Zhejiang University. Science. B》2014,15(2):153-164
The aim of this present study is to investigate the effect of Zanthoxylum bungeanum oil (essential oil from Z. bungeanum Maxim.) on cytotoxicity and the transdermal permeation of 5-fluorouracil and indomethacin. The cytotoxicity of Z. bungeanum oil on dermal fibroblasts and epidermal keratinocytes was studied using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The rat skin was employed to determine the percutaneous penetration enhancement effect of Z. bungeanum oil on hydrophilic and lipophilic model drugs, i.e., 5-fluorouracil and indomethacin. The secondary structure changes of the rat stratum corneum (SC) were determined using attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), and saturated solubilities and SC/vehicle partition coefficients of two model drugs with and without Z. bungeanum oil were also measured to understand its related mechanisms of action. It was found that the half maximal inhibitory concentration (IC50) values of Z. bungeanum oil were significantly lower in HaCaT and CCC-ESF-1 cell lines compared to the well-established and standard penetration enhancer Azone. The Z. bungeanum oil at various concentrations effectively facilitated the percutaneous penetration of two model drugs across the rat skin. In addition, the mechanisms of permeation enhancement by Z. bungeanum oil could be explained with saturated solubility, SC/vehicle partition coefficient, and secondary structure changes of SC. 相似文献
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