Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

运动与铁代谢

长期、剧烈的运动训练可以导致铁代谢的紊乱,从而引发机体缺铁的发生,也是导致运动性贫血发生的重要原因。运动导致缺铁引起铁代谢失调可能与运动导致铁吸收下降、摄入不足、铁丢失增加、不良的饮食习惯、溶血以及机体应激有关。反映机体铁代谢状况的指标有了一定的研究,血清铁、血清铁蛋白浓度、转铁蛋白浓度以及其它指标的变化在一定程度上可以反映机体铁代谢状况,并在运动实践中用于监测运动员铁状况以及铁制剂服用效果的观察。在运动实践中铁制剂的补充对防治铁缺乏具有一定的效果,但针对性不强,缺乏指标与应用效果的更好的结合。     

对中长跑运动员训练机能评定的实验研究

观察了不同训练水平男子中长跑运动员不同强度训练负荷后血清免疫球蛋白水平的变化。结果提示:大强度训练可降低男子中长跑运动员机体的体液免疫水平,其测定有助于掌握运动强度和负荷量,为合理安排训练计划提供依据。     

改良小梁切除与传统小梁切除的疗效观察研究

目的:评价小梁切除术中改良巩膜瓣、睫状突定量小梁切除、不同缝合方式在术中术后的优缺点及远期疗效。方法120例(156眼)原发性青光眼随机分为4组:A组(传统术式组)30例(42眼);B组(可拆褥式缝线组)30例(40眼);C组(L形巩膜瓣小梁切除组)30例(34眼);D组(小切口睫状突定量小梁切除术组)3 0例(40眼),B.C.D组为改良术式组。比较4组术后浅前房、眼压和滤过泡情况。结果:浅前房发生率:A组26.119%(11/42),B组7.50%(3/40),C组2.94%(1/34),D组2.50%(1/40),改良术式组与传统术式组比较差异有板有统计学意义(P<0.01);随诊眼压:A组(14.65±4.30)mmHg,B组(1 3.87±3.60)m mHg,C组(15.58±3.20)mmHg,D组(14.50±3.15)mmHg,4组间差异无统计学意义(P>0.05);随诊功能性滤过泡A组76.19%(32/42),B组92.50%(37/40),C组97.05%(33/34),D组95.00%(38/40),传统小梁切除组与改良小梁切除组比较差异有统计学意义(P<0.05)。结论采用巩膜瓣可拆褥式缝合、L形巩膜瓣小梁切除、小切口睫状突定量小梁切除可大大降低术后浅前房的发生率,并能理想地控制眼压,提高术后视功能。     

大强度运动对机体免疫功能的影响

大强度运动可降低机体的免疫功能,可能与运动时的应激反应、运动时红细胞免疫力降低、运动性贫血、自由基生成增多、线粒体变性以及运动时的营养消耗有关。     

"优秀生心理综合症"及运动处方

成绩优秀的学生往往存在一些特殊的心理问题，预防和消除优秀生的心理问题具有十分重要的意义。在进行体育教学和身体锻炼的同时，适当地运用运动处方，可以治疗优秀学生的心理疾病和消除心理障碍，促进优秀学生健康成长。     

硒,硒缺乏和运动

硒是人体必须的微量元素,近年来,硒的生化作用的研究已成为国内外研究的兴奋点.而硒缺乏与运动对人体的影响在运动医学界取得的成就也日益引起人们的关注,这也为运动界,营养学界提供了新参考.     

从鲁迅杂文看当下杂文形象性的缺失

杂文是融政论性和艺术性于一体的文艺性社会论文,文学性或日形象性是其重要的特征.鲁迅杂文在勾勒形象、托物寓理、以事晓理和画龙点睛等方面充分显示了形象性.本文据此剖析当下杂文在形象性缺失方面存在的问题:通篇论述,形象不足;以理说理,直陈乏味;就事论事,画龙少睛;表达单一,语言枯燥.     

Physical activity and nutrition guidelines to help with the fight against COVID-19

ABSTRACT

As the world is witnessing the epidemic of coronavirus disease 2019, emerging genetics and clinical pieces of evidence suggest a similar immunopathology to those of severe acute respiratory syndrome and Middle East respiratory syndrome. Staying at home to prevent the spread of the virus and consequently being largely inactive is associated with unintended consequences. These can actually enhance the infection risk and exacerbate poor health conditions including impaired immune function. Physical activity is a feasible way of improving health, particularly physical and mental health in a time of social isolation. However, people with certain health conditions in these circumstances may need a special physical activity programme in addition to any exercise they may already be performing via online programmes. This review aims to provide practical guidelines during the COVID-19 quarantine period. We suggest performing aerobic, resistance training, respiratory muscle training and yoga in the healthy, and in those with upper respiratory tract illness, patients with lower respiratory tract illness should be restricted to respiratory muscle training and yoga. In addition, vitamins D and C, omega-3 fatty acids, and regular consumption of fruit and vegetables might be considered as nutritional aids to support the immune system in those affected by COVID-19.     

急性运动降低感染风险的免疫调节机制

由于新型冠状病毒(2019-nCoV)感染的肺炎疫情暴发,人们将居家运动作为提高免疫力与保持健康的重要手段,运动与免疫的关系再度受到关注。一般认为,在充分恢复的前提下进行规律的中高强度运动可提高免疫功能,而急性运动(acute exercise)可能抑制免疫功能并增加感染风险。急性运动后外周血淋巴细胞计数及功能降低、免疫球蛋白A水平分泌减少被认为是运动抑制免疫的理论基础。但目前这种独立于非运动因素影响免疫功能增加感染风险的认识受到了现有研究的挑战。急性运动可通过应激反应将淋巴细胞亚群迅速动员至循环中,运动结束后,淋巴细胞亚群又会迅速迁移至外周组织。淋巴细胞的重新分布(lymphocyte redeployment)可能是一种进化保守的免疫机制,这一过程强化了外周组织的免疫监视与调节功能,有助于提升机体抵抗感染能力。因此,从这一视角就急性运动对机会性感染风险及免疫功能影响的现状进行综述。