太极拳对老年人心肺机能的影响

通过系统观察、测试部分长年参加太极拳练习者和无训练者在完成定量负荷运动前后心肺功能指标变化,发现长期进行太板拳练习的老年人心脏泵血功能、心肌收缩机能、肺活量均显著优于普通人,表明长年从事太极拳运动对促进老年人心肺功能的改善具有积极作用,为老年人参加太极拳运动提供了可靠的实验依据.     

对不同项群运动员运动负荷前后左心室舒张功能的观察

为了评价不同项群运动员左心室舒张功能,对12名耐力项目运动员和12名速度力量项目运动员12min前后二尖瓣血流频谱进行了检测。结果表明:12min跑后耐力组血流速度积分和E/A明显减小,速度力量组血流速度积分、E峰值和E/A减小十分明显,A峰值减小明显,两组运动员血流速度积分、E峰值和E/A存在显著差异。说明,耐力组左心室舒张主动松驰及被动充盈能力均好于速度力量组。     

食管癌外科治疗近期疗效的影响因素分析

目的探讨食管癌患者年龄、吻合位置与术后并发症发生率和死亡率的关系,以及新辅助化疗对食管癌手术切除率的影响。方法回顾性分析西安交通大学医学院第一医院肿瘤外科自1997年~2003年首诊收治、资料完整587例食管癌患者资料。结果不同年龄组手术切除率分别为91.2%、95.9%和97.7%(P>0.05);>70岁年龄组术后吻合口瘘发生率和术后死亡率均较其它组高(P<0.05)。胸膜顶部吻合口瘘发生率为16.67%,较其它位置吻合口瘘发生率明显高(颈部2.17%、弓上1.09%、弓后2.60%、弓下0),具有显著性差异(P=0.019)。III期食管癌患者行术前新辅助化疗组与未化疗组的手术切除率分别为96.92%和78.85%,具有显著差异(P<0.05),而术后吻合口瘘发生率和术后死亡率无明显差异(P=1.000)。结论术前新辅助化疗可提高食管癌手术的切除率并不增加术后并发症。年龄大并不完全是手术禁忌,高龄患者的手术应充分考虑患者的生理年龄。     

散步对中老年高级知识分子心脏功能影响的追踪分析

对采用散步作为锻炼手段的40名中老年高级知识分子的心脏功能指标进行追踪测试，显示散步可使中老年高级知识分子的PR、HOV、HOI降低；SV、SI、VPE、EWK升高；而对于CO、CI、LVWI的影响较小。提示坚持散步对提高中老年高级知识分子的心脏功能有较好的作用。     

心衰康煎液对阿霉素心衰模型大鼠心肌的影响

目的观察中药复方制剂"心衰康煎液"对心衰大鼠心脏血流动力学的影响及心肌细胞的病理学改变.方法利用pclab实验记录分析系统观察和分析各实验组大鼠左心室内压、对大鼠心肌切片H.E染色镜下观察.结果心衰康使心衰得到明显改善,心肌细胞无明显变性、坏死.结论中药复方"心衰康煎液"对心衰大鼠的心肌病变有明显改善,从而产生良好的抗心衰作用.结论     

Alterations in autonomic cardiac modulation in response to normobaric hypoxia

Purpose: The present study aimed to determine if autonomic cardiac modulation was influenced by acute exposure to normobaric hypoxia. Method: Ten healthy male lowland dwellers completed five block-randomised single-blinded, crossed-over acute exposures to a normobaric hypoxic environment, each separated by 24 hours’ recovery (20.3%, 17.4%, 14.5%, 12.0% and 9.8% F_IO₂). Supine recordings were made of arterial oxygen saturation and electrocardiogram (ECG). RR intervals from the ECG trace were analysed for time (SDNN, lnrMSSD), frequency (lnVLF, lnLF, lnHF, lnTP, LFnu, and HFnu), and nonlinear (DFA-α1 and SampEn) heart rate variability components. Results: A significant reduction in arterial SaO₂ occurred with reduced F_IO₂, along with a rise in heart rate (Cohen’s d?=?1.16, 95% Confidence Interval [2.64–6.46]), significant at 9.8% F_IO₂. A decrease in autonomic cardiac modulation was also found as shown by a statistically significant (at 9.8% F_IO₂) decrease in lnTP (d?=?1.84 [1.74–1.94]), and SampEn (d?=?0.98 [0.83–1.12]) and an increase in DFA-α₁ (d?=?0.72 [0.60–0.84]) from normoxia at 9.8% F_IO₂. Conclusion: The decrease in variability indicated a reduction in autonomic cardiac modulation. There appears to be a threshold ～9.8% F_IO₂ (～6000?m equiv.), below which significant alterations in autonomic control occur.     

心安灵对麻醉犬心肌缺血的保护作用

目的:观察心安灵对冠脉结扎麻醉犬的保护作用.方法:麻醉犬冠脉结扎复制心肌缺血模型.观察给药后ST段偏移总和(Σ-ST)、ST段抬高≥2mv的个数(N-ST)、LDH、CK释放的变化.结果:心安灵可显著减少冠脉结扎所致的Σ-ST抬高和N-ST增加,同时减少血清中LDH和CK的释放.结论:心安灵对麻醉犬冠状动脉结扎所致的心肌缺血具有明显改善作用.     

微课在外科教学中的发展与探索

外科作为临床医学核心课程之一,基本以课堂理论教学—实践课操作练习—毕业实习的模式展开,教学周期长达一年及以上。学科涵盖知识量大,教师在有限的理论课上呈现的往往是提炼、概括、浓缩后的知识点。而实践课及毕业实习一般采用传统"传帮带"的方式进行,一过性的演示不利于学生真正掌握技能。2011年微课概念被引入国内,作为一种新型信息教育形式,微课以其"主题突出、情境真实、短小精悍、交互性好"等特点被广泛认可。微课包括微课结合其他新型教育形式在逐渐应用于外科教学中,其效果得到越来越明确验证的同时,也暴露出了一些问题。     

Video-assisted thoracoscopic surgery （VATS） for bilateral primary spontaneous pneumothorax

Objective:To review our experience of the treatment of bilateral primary spontaneous pneumothorax (PSP) by video-assisted thoracoscopic surgery (VATS). Materials and methods: Retrospective chart review was followed by an on-clinic or telephone interview. Patients were cared for by one thoracic surgeon in four medical centers or community hospitals in Northern and Central Taiwan. Thirteen patients with bilateral PSP underwent bilateral VATS simultaneously or sequentially from July 1994 to December 2005. Results: Twelve males and one female, with age ranging from 15 to 36 years (mean 23.1 years), were treated with VATS for bilateral PSP, under the indications of bilateral pneumothoracis simultaneously (n=4) or sequentially (n=9). The interval between the first and second contra-lateral VATS procedure for non-simultaneous PSP patients ranged from 7 d to 6 years. Eleven of 13 patients (84.6%) had prominent pulmonary bullae/blebs, and underwent bullae resection with mechanical or chemical pleurodesis. The mean operative time was (45.6±18.3) min (range 25-96 min) and (120.6±28.7) min (range 84-166 min) respectively for the non-simultaneous (second VATS for the recurrence of contralateral side after first VATS) and simultaneous (bilateral VATS in one operation) procedures. There was no postoperative mortality. However, prolonged air leakage (>7 d) occurred in one patient (7.7%) who recovered after conservative treatment. The mean duration of chest tube drainage was 3.1 d and the median follow up period was 3.4 years. Conclusions: VATS is a safe and effective procedure in the treatment of bilateral PSP. Bilateral VATS is only recommended for patients with simultaneously bilateral PSP, because the incidence of recurrence, even with visible bullae, was not so high in my group and in some previous literature. Bilateral VATS in a supine position should only be used in selective cases, because of possible pleural adhesion or hidden bullae on the posterior side.     

Cardioprotective activity of synthetic guggulsterone (E and Z-isomers) in isoproterenol induced myocardial ischemia in rats: A comparative study

Guggulsterone, a mixture of cis (E) and trans (Z) isomers (7∶3 w/w) was synthesized from 16-DPA. The isomers were separated by column chromatography and evaluated for cardioprotective and antioxidant activities. Myocardial necrosis induced by isoproterenol in rats caused marked increase in serum creatine phosphokinase and glutamate pyruvate transaminase. Simultaneously in ischemic heart, phospholipase, xanthine oxidase and lipid peroxides were enhanced following depletion of glycogen, phospholipids and cholesterol. Treatment with guggulsterone and its both isomers at the dose of 50 mg/kg po., significantly protected cardiac damage as assessed by the reversal of blood and heart biochemical parameters in ischemic rats. The cardioprotective activity of guggulsterone and of both the isomers were compared with that of gemfibrozil at the same doses. Guggulsterone and both the isomers at tested concentrations (5–20mM) inhibited oxidative degradation of lipids in human low-density lipoprotein and rat liver microsomes induced by metal ionsin vitro. The drug counteracted against the generation of superoxide anions (O₂) and hydroxyl radicals (OH⁻) in non-enzymic test systems. It is suggested that cardioprotective and antioxidant activities of synthetic guggulsterone and guggulsterone obtained from gum resinCommiphora mukul that contains isomers E & Z in the ratio of 46∶54w/w are the same.