Glocalization and Other Challenges to Cataloging Chinese Continuing Resources

ABSTRACT

Glocalization describes the adaptation of international products around the particularities of a local culture, and extends to areas beyond political campaigns and cultural communication. Chinese continuing resources are effectively influenced by glocalization, which reflects the changing society in China and Chinese overseas communities, as well as the changing practice in Chinese studies all over the world. Glocalization brings unexpected challenges to a library's cataloging service, and a number of issues need to reach our awareness and be solved. We have to face squarely its influence, and look for an appropriate solution in handling Chinese continuing resources under glocalization.     

再论《吴医汇讲》为中国期刊的肇端

基于无限期出版的意图和具有定期或不定期连续出版的特征是期刊最根本的2个属性,提出了《吴医汇讲》第1卷单卷刊行传播和9册本、6册本、5册本、4册本分卷、分册刊行的文字证据和版本实物证据,彻底颠覆了认为其在”3个年份里2次刻成,故非连续出版物”的错误观点,再次巩固了其为中华第一刊的正确结论.     

周边不规则大型深基坑地下水控制设计

地下水控制是大型深基坑工程中的关键技术。结合某周边不规则的深基坑工程,从基坑周边既有工程环境、施工场地条件、基坑地质和含水层特征等多方面综合考虑,对基坑场地内上层滞水和孔隙承压水分别提出控制设计思路,给出排水管路、深井降水网布置设计方法,以及降水井结构设计图,最后评价地下水控制对深基坑周围环境的影响。对于类似建筑,具有一定的参考价值。     

英语中“水”的概念分析

与科学世界图景中的水概念不同,语言世界图景中水的概念化呈现出自己的特点。通过对以水为关键词的搭配为语料对水进行的概念分析发现,英语中将水概念化为动物、人、有固定外形的物体和无固定外形的物体。尽管其概念化呈现出无序性和非逻辑性,但反映出在英伦民族意识中对水这一概念的初始认识。     

A proof of concept for neutralizing antibody-guided vaccine design against SARS-CoV-2

Mutations and transient conformational movements of the receptor binding domain (RBD) that make neutralizing epitopes momentarily unavailable present immune escape routes for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To mitigate viral escape, we developed a cocktail of neutralizing antibodies (NAbs) targeting epitopes located on different domains of spike (S) protein. Screening of a library of monoclonal antibodies generated from peripheral blood mononuclear cells of COVID-19 convalescent patients yielded potent NAbs, targeting the N-terminal domain (NTD) and RBD domain of S, effective at nM concentrations. Remarkably, a combination of RBD-targeting NAbs and NTD-binding NAbs, FC05, enhanced the neutralization potency in cell-based assays and an animal model. Results of competitive surface plasmon resonance assays and cryo-electron microscopy (cryo-EM) structures of antigen-binding fragments bound to S unveil determinants of immunogenicity. Combinations of immunogens, identified in the NTD and RBD of S, when immunized in rabbits and macaques, elicited potent protective immune responses against SARS-CoV-2. More importantly, two immunizations of this combination of NTD and RBD immunogens provided complete protection in macaques against a SARS-CoV-2 challenge, without observable antibody-dependent enhancement of infection. These results provide a proof of concept for neutralization-based immunogen design targeting SARS-CoV-2 NTD and RBD.     

Accidental digitoxin intoxication: an interplay between laboratory and clinical medicine

Introduction:

Two Italian adults arrived at the Emergency Department referring diarrhea, nausea and vomiting for 4 days; weakness, fatigue and visual hallucinations were also complained of. Patients reported the ingestion of some leaves of a plant, which they supposed to be “donkey ears”, a week before. Physical examination showed hypotension and bradycardia and ECG examination disclosed sinus rhythm and repolarization abnormalities (scooping of the ST-T complex) in both patients and a 2:1 AV block in the man.

Materials and methods:

Digoxin concentration was evaluated twice for each patient (at the admission and after 4 hours) by the automated immunoassay system ADVIA Centaur^®. Digitoxin concentration was evaluated by liquid chromatography-mass spectrometry (LC-MS/MS).

Results:

Despite clinical picture was suggestive of digitalis intoxication, digoxin levels were undetectable. Due to the more severe clinical picture, the male patient was treated with anti-digoxin antibodies (Digifab^®) achieving a good clinical improvement and remission of the AV block within two hours. Initial diagnosis was confirmed by LC-MS/MS showing high digitoxin concentrations, but digoxin was undetectable. Patients remained stable and 48 hours later were discharged from the hospital.

Conclusion:

Whereas digoxin determination frequently relies on monoclonal antibodies which do not cross-react to digitoxin, polyclonal antibodies constituting Digifab^® recognize a large spectrum of cardiac glycosides, including digitoxin. This report emphasizes the primary role of the clinical approach to patients in the emergency setting and how an active communication and a continuous sharing of professional experiences between Laboratory and Clinicians ensure an early and correct diagnosis.     

Rapid visual processing by college students in reading irregular words and phonologically regular pseudowords presented singly and in contiguity

Using normal adult readers, this study examined the relative involvement of magnocellular and parvocellular processes in reading English phonologically regular pseudowords and irregular words presented in isolation and in contiguity from left to right. The data showed that a low temporal frequency visual measure that implied more parvocellular involvement was active in processing irregular words presented singly and pseudowords presented in contiguity. However, the results failed to show the involvement of the magnocellular pathway (as implicated by low spatial and/or high temporal frequency visual measures) in reading words presented in contiguity from left to right. The discrepancy was discussed in terms of the sensitivity of the tasks used in testing the two pathways.     

抗-CCP抗体检测在类风湿关节炎诊断中的应用

目的探讨抗-CCP抗体检测在类风湿关节炎诊断中的作用。方法回顾性分析了125例疑为风湿疾病患者及33例类风湿关节炎（RA）患者抗-CCP抗体和RF检测结果。结果 125例疑为风湿疾病患者中,抗-CCP抗体阳性31例、RF阳性10例,其中确诊的33例RA患者抗-CCP抗体阳性31例、RF阳性9例。结论抗-CCP抗体检测是RA早期诊断一种十分有效的方法。     

英语不规则动词的演变与英语发展整体趋势的自相似性

本文用混沌学的分形理论分析了英语不规则动词的演变,认为英语不规则动词的演变和英语发展的整体趋势存在自相似性。     

空间隐喻向时态映射在英语不规则动词双元音变化中的体现

空间隐喻属于概念隐喻的三种分类之一,是认知的基础。时间概念是抽象的,具体的空间方位词可用来描述和衡量时间的变化。文章基于时间的空间隐喻系统,观察大量不规则动词过去式双元音发音位置的变化,分析对比得出:时间的空间隐喻系统在语音方面也有所呈现。这印证了隐喻是一种认知方式并普遍存在于人类的思维中这一观点。