Changes of oxidative and lipoperoxidative metabolism in patients with acute viral myocarditis

Objective: To study the changes of oxidative metabolism and lipoperoxidative metabolism in patients with acute viral myocarditis (AVM), and to research pathological chain reactions of a series of free radicals, and oxidative damage and lipoperoxidative damage in AVM patients' bodies. Methods: A random paired control design was used to investigate 70 cases of AVM patients and 70 cases of healthy adult volunteers (HAV) on the basis of contents of nitric oxide (NO), lipoperoxide (LPO) in plasma, and LPO in red blood cell (RBC) as well as activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px) in RBC as revealed by spectrophotometric assays. Results: Compared with the average values (AV) of the above biochemical parameters (BP) in the HAV group, the AV of NO in plasma, and LPO in plasma and in RBC in the AVM group were significantly increased (P=0.0001), while the AV of SOD, CAT and GSH-Px in the AVM group were significantly decreased (P=0.0001). Conclusion: The findings in this study suggested that in the AVM patients bodies the metabolism of NO was disturbed, and the pathological chain reactions of a series of free radicals were so severely aggravated, as to cause the oxidative damage and lipoperoxidative damage in the AVM patients' bodies.     

运动结合绞股蓝总皂甙对高脂血症大鼠血脂和脂质过氧化水平的影响

目的:研究有氧运动和/或绞股蓝总皂甙对实验性高脂血症大鼠血脂的调节机制并探索其抗脂质过氧化的机理.方法:用高脂饲料喂饲大鼠6周,复制成高脂血症模型.而后进行4周的有氧运动、绞股蓝总皂甙干预和运动结合胶股蓝总皂甙干预.干预4周后处死动物,比较血清总胆固醇及甘油三酯含量、血清高密度脂蛋白胆固醇和低密度脂蛋白胆固醇含量,同时测定血清SOD、CAT和MDA的浓度.结果:有氧运动和绞股蓝总皂甙均可显著降低大鼠血清低密度脂蛋白胆固醇、总胆固醇、甘油三脂浓度,提高高密度脂蛋白胆固醇水平;运动结合绞股蓝总皂甙组大鼠血清超氧化物歧化酶、谷胱甘肽过氧化物酶及过氧化氢酶显著升高,脂质过氧化产物水平显著降低.结论:绞股蓝总皂甙结合有氧运动可治疗高血脂症大鼠血脂异常并有较明显的抗脂质过氧化作用.     

CHANGES OF OXIDATIVE AND LIPOPEROXIDATIVE METABOLISM IN PATIENTS WITH ACUTE VIRAL MYOCARDITIS

ＩＮＴＲＯＤＵＣＴＩＯＮＭｙｏｃａｒｄｉｔｉｓｉｓａｃｏｍｍｏｎｃａｒｄｉａｃｄｉｓｅａｓｅ.Ｔｈｅｒｅａｒｅｒｅｐｏｒｔｓｔｈａｔａｃｔｉｖｉｔｉｅｓｏｆｓｕｐｅｒｏｘｉｄｅｄｉｓ ｍｕｔａｓｅａｎｄｃａｔａｌａｓｅｉｎｂｌｏｏｄｏｆｖｉｒａｌｍｙｏｃａｒｄｉｔｉｓｐａｔｉｅｎｔｓａｎｄａｎｉｍａｌｓｐｒｏｄｕｃｅｄｓｏｍｅｃｈａｎｇｅｓ,ａｎｄａｇｇｒａｖａｔｅｄｒｅａｃｔｉｏｎｓｏｆｆｒｅｅｒａｄｉｃａｌｓｉｎｔｈｅｉｒｂｏｄｉｅｓ (Ｈｉｒａｏｋａｅｔａｌ.,1 992 ,1 993 ,1 995;Ｓｕｚｕｋｉｅ…     

Inhibition of probimane on lipoperoxidation of human red cells in vitro

铮? Ｈｕｍａｎ Ｒｅｄ Ｃｅｌｌｓ ｉｎ ＶｉｔｒｏTX１ＩｎｔｒｏｄｕｃｔｉｏｎＰｒｏｂｉｍａｎｅ,ａｓａｎａｎｔｉｎｅｏｐｌａｓｔｉｃａｇｅｎｔｆｉｒｓｔｄｅｖｅｌ－ｏｐｅｄｉｎＣｈｉｎａ［１］ｗａｓａｄｅｒｉｖａｔｉｖｅｏｆｒａｚｏｘａｎｅ．Ｔ?..