Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

一种微弱电阻测量仪的设计

设计一种基于四线制电流倒向技术的微弱电阻测量仪,经实验验证,该测量仪可以很好地满足测量要求,并具有良好的重复测量精度.     

陕西省城市“弱势群体”健身状况的调查研究

对陕西省城市弱势群体参与健身活动和身体健康状况进行抽样调查。结果显示陕西省城市弱势群体的健康状况极差 ,健身意识不强、健身活动太少是其主要原因。提出了强化对弱势群体的救助和关注 ,不能仅限于生活上的关心、经济上的资助 ,还应关心他们的体质与健康 ,支持他们参与健身活动。     

“弱者优先”训练原则中“薄弱环节”与“关键环节”的判定方法

在运动训练实践中,要贯彻和执行好“弱者优先”原则,首先要正确判定动作模式的“关键环节”与“薄弱环节”。为此,以原地纵跳动作为实例,阐述了判定“关健环节”与“薄弱环节”的具体方法。     

The Impact of Museum Purchase on the Auction Prices of Paintings

This study examines how art museumspurchasing policy influences the auction prices ofpaintings. Using a cross section of non-speculativetransactions during the period 1820–1970, we findconsiderable empirical support for the hypothesisthat public museums outside the U.S. pay above averageprices in auction markets providing higher thanaverage yields to private sellers. The typical U.S.private museums appear to be more restricted byfinancial constraints and the development of thegeneral economic conditions than their publiccounterparts.     

公共图书馆在和谐社会如何为弱势群体服务

论述了关注弱势群体对和谐社会的重大意义,图书馆在和谐社会中为弱势群体服务的必要性,进一步阐述了图书馆为弱势群体服务的具体措施。     

对民国档案文件级整理工作的思索

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。     

COUNTER R5的新特性及对图书馆的影响

COUNTER是规范网络化电子资源使用统计报告数据处理、审核和提交的国际化标准,是图书馆电子资源使用量统计和评估的核心要素。目前COUNTER已经发布了最新版本R5,了解R5的新特性及与之前版本的不同对于图书馆的电子资源统计工作具有重要意义。本文拟从COUNTERR5的报告设置、报告的指标类型、数据类型、访问类型和其他完善报告的属性来解析R5,同时介绍R5对SUSHI收割的影响、"持续维护"的概念、R5发布对图书馆的影响和R5实施的重要时间节点,同时也对R5较之R4的发展和不同进行了比较和分析。COUNTERR5的主要关注点是一致性、清晰性和简单性,较之COUNTERR4有了明显的完善,同时包含了持续的维护过程,允许对代码进行更新而不必再引入一个全新的版本,解决了版本升级会对供应商和图书馆带来的各种时间和人员成本的影响。     

基于系统动态学方法的弱信号生命周期建模与仿真

[目的/意义]为增强弱信号的内涵研究，对其全生命周期过程下的各阶段要素以及要素间的联系进行探寻，以期获得一定程度上的理论贡献，同时也为相关组织在开展弱信号管理实践时提供理论指导。[方法/过程]在对弱信号概念研究现状进行梳理的基础上，结合意义构建理论给出了弱信号概念界定。随后，通过与信息生命周期、新兴议题生命周期进行类比，提出弱信号生命周期理念。进而采用系统动态学方法开展系统思考，使用因果回路图进行系统建模，运用存量流量图进行仿真模拟。[结果/结论]弱信号生命周期包含4个阶段：侦测、关联、传递、抉择，相应的系统动态学模型所具备的现实性得到验证，且通过情景模拟确认了4个关键辅助变量：外界噪声干扰程度、弱信号分析效率、组织内相互信任程度、决策者信任程度。在整体研究的基础上，给出弱信号管理过程中可能会遇到的障碍以及应对策略。