Clinicopathological features of atypical lipomatous tumors of the laryngopharynx

Atypical lipomatous tumor (ALT) of the laryngopharynx is rare. Here we report five cases to demonstrate their clinicopathological features. The patients were four males and one female, aged 41 to 69 years (median 53.6 years). All tumors (two in the hypopharynx and three in the larynx) presented as a slowly growing, painless mass. Symptoms included dysphagia (2/5), dysphonia (3/5), and the feeling of a foreign body in the throat (5/5). Tumors were well circumscribed or focally infiltrative, ranging from 2.0 to 5.0 cm (median, 3.4 cm) in size, and microscopically showed the typical features of lipoma-like ALT. Immunohistochemically, tumor cells were stained with S-100, vimentin, murine double minute 2 (MDM-2), and cyclin-dependent kinase 4 (CDK4). Two patients had local tumor recurrences at 6 and 14 months after initial surgery during follow-up. ALT of laryngopharynx is an indolent tumor. Immunohistochemical staining for MDM-2 and CDK4 is helpful in pathological diagnosis.     

肝病患者血清总胆汁酸测定的临床意义

目的探讨肝脏疾病临床诊断中血清总胆汁酸（TBA）测定结果的临床意义。方法在日立7600型全自动生化分析仪上检测272例肝病患者（急性肝炎98例、慢性活动性肝炎54例、肝硬化71例和肝癌49例）的血清TBA、ALT,并与健康对照组比较。结果各种肝病患者的TBA、AIT均显著升高。急性肝炎、慢性活动性肝炎TBA与ALT升高显著,敏感性高,但肝硬化、肝癌两项指标阳性率结果差异明显（χ^2=60．553,P〈0．001）：TBA阳性率高达90％以上,而ALT阳性率仅为20％左右。结论TBA测定对于监测慢性肝病,尤其是肝硬化的早期诊断价值很大,是一项很具实用价值高敏威性的肝功能诊断指标。     

补充大豆多肽对递增负荷运动大鼠血清LDH、ALT、AST活性的影响

观察了5周递增负荷训练并同时补充大豆多肽后的大鼠在运动后某些血清酶的变化,旨为在训练中补充大豆多肽对身体机能及运动后恢复的作用提供一定的理论依据.结果发现:补充大豆多肽降低了运动后血清LDH和AST活性.提示:补充大豆多肽可能起到预防骨骼肌和心肌运动性微损伤和促进损伤恢复的作用.     

日本"JET计划"简介

“JET”计划是“日本教学交流计划”的简称,它是日本政府为充实外语教学,增进日本与外国的相互理解而开展的计划,该计划至今已经实施了15年,在增进国际交流、外语教育改革方面起到了积极的作用。     

中药复方对免疫损伤性肝纤维化大鼠肝损害的疗效观察

目的:研究中药复方方剂对免疫损伤性肝纤维化大鼠肝损害的治疗作用.方法:给大鼠腹腔注射猪血清,制备肝纤维化模型,以低剂量、高剂量中药复方颗粒治疗,测定治疗前后的ALT、A、G、A/G和PT,结合肝组织切片及细胞化学染色观察判断疗效.结果:与正常对照组比较,模型组ALT显著升高(P<0.001),A/G比值显著低于正常组(P<0.05);血浆凝血酶原时间(PT)明显延长(P<0.0005);肝纤维化明显;胶原纤维密度、巨噬细胞和储脂细胞显著高于正常组(P<0.05).治疗组一般状态良好,高、低剂量治疗组ALT(0.01相似文献   

Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease

Objective:To investigate the relationship between alanine aminotransferase (ALT)levels and metabolic syndrome (MS)in nonalcoholic fatty liver disease(NAFLD).Methods:A total of 26527 subjects who received medical health checkup in our hospital from January 2005 to July 2007 were enrolled in the study.The diagnosis of fatty liver was based on ultrasound imaging.MS Was defined according to the criteria of the Adult Treatment Panel Ⅲ.ALT,triglyceride(TG),high density lipoprotein cholesterol(HDL-c),fasting plasma glucose(FPG),height,weight,waist circumference(WC),systolic blood pressure (SBP)and diastolic blood pressure(DBP)were measured in each subject to analyze the relationship between MS and ALT activity.Results:(1)The prevalence of NAFLD in men(30.94%)was significantly higher than that in women(15.65%);(2)The incidence of MS in NAFLD(33.83%)was significantly greater than that in non-NAFLD(10.62%);(3)Of the 6470 subjects with NAFLD,in the age-adjusted partial correlation analysis,there were statistically significant correlations between the ALT levels and most metabolic risk factors in each sex(P＜0.01),except that ALT levels had no correlation with HDL-c in women.Moreover,in the multiple stepwise regression analysis,SBP lost its significance,and WC,body mass index(BMI),age,DBP,TG and FPG were independently associated with ALT levels in both sexes (P＜0.05).HDL-c remained significant and was independently related to ALT leveis in men;(4)ALT levels were significantly higher in subjects with MS compared to those without MS(P＜0.001).Mean ALT levels increased with the number of MS cornponents in each sex (P.＜0.05 for trend).Conelusion:We found a strong relationship between ALT leveIs and MS in NAFLD and revealed that the cluster of MS components might be the predictor for ALT elevations.     

乌索酸对D-氨基半乳糖致小鼠急性肝损伤的影响

目的：研究乌索酸抗急性肝损伤的作用．方法：利用D-氨基半乳糖（D-GalN）建立小鼠急性肝损伤病理模型，分别以乌索酸按15、30、60mg／kg小鼠口服给药，观察其对急性肝损伤小鼠血清丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、肝组织丙二醛（MDA）含量及肝脏形态学的影响．结果：急性肝损伤模型组与正常对照组比较，各项指标差异均有显著性（P〈0．01）；乌索酸组与模型组比较，血清ALT、AST、MDA明显降低（P〈0．05），光镜下肝细胞脂肪变性、水样变性明显减轻；结论：乌索酸对D—GalN所致的急性肝损伤小鼠具有保护作用．     

The Validity of Academic Learning Time–Physical Education (ALT–PE) as a Process Measure of Achievement

Abstract

The purpose of this study was to determine whether the ALT–PE system (Version 2) is valid as a process approach to estimate student achievement. Students (N = 60) were randomly selected from a data base that includes pretest and posttest scores for two volleyball skills and seven sessions of videotaped instruction. Videotapes were collected using two cameras with a split-screen generator so most instruction and practice could be seen. ALT–PE data were coded from the videotapes. In addition to normal ALT–PE coding conventions, coders recorded the skill that was the focus of instruction. Combinations of context and learner involvement categories were summed for each skill across the seven class sessions and to form other logical categories (e.g., total motor appropriate intervals). Achievement scores were calculated by posttest on pretest regression for each skill with the residual score used for subsequent analysis. Residual achievement scores were correlated with summed ALT–PE categories. The results indicate for the serve both total motor appropriate and practice–motor appropriate intervals were related to student achievement. For the pass, practice–motor appropriate intervals were related to achievement and the total motor appropriate–achievement correlation failed significance. These results demonstrate the validity of the ALT–PE system as a process measure of achievement can be partially substantiated.     

On the Trajectories of the Predetermined ALT Model: What Are We Really Modeling?

This article shows that the mean and covariance structure of the predetermined autoregressive latent trajectory (ALT) model are very flexible. As a result, the shape of the modeled growth curve can be quite different from what one might expect at first glance. This is illustrated with several numerical examples that show that, for example, a linear trajectory might be present among the model predicted scores even though no latent change parameter was included in the model. In addition, 2 examples are given that show that the predetermined ALT model can fit to data generated by models with model structures that are rather different from that of the ALT model itself. The practical relevance of these findings is demonstrated using an empirical example. We end by providing recommendations for researchers considering the use of the predetermined ALT model.     

"高住低练"对运动员安静状态下血清CK、LDH、ALT活性的影响

目的探讨"高住低练"过程中,运动员安静时血清酶的变化规律.方法20名运动员随机分为高住低练组和低住低练组,每组10名,分别测定运动员在此过程中安静状态下血清肌酸激酶(CK)、乳酸脱氢酶(LDH)和谷丙转氨酶(ALT)的活性.结果在高住低练的初期,运动员血清CK、LDH活性明显高于对照组,而高住低练4周后,血清酶活性则明显低于对照组,并可连续到高住低练后2周.结论提示运动员在2 500m高度进行4周高住低练,机体对缺氧负荷和运动负荷的适应后,能降低由于运动引起的血清酶活性的升高,对防止肌肉组织的损伤和增加细胞膜的稳定性有一定的作用.