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Eighty-two patients with supraventricular tachycardia undergoing radiofrequency catheter ablation (RFCA) were studied to observe
the inhibition effect of aspirin and ticlopidine on platelet aggregability (PAG) and thromboxane B2 (TXB2) of the blood samples. Patients were divided into aspirin group A, ticlopidine group B, aspirin + ticlopidine group C and
control group D. PAG and TXB2 were increased clearly after RFCA in all groups (P<0.001). Treatment with aspirin or ticopidine before operation could reduce the platelet aggregability caused by RFCA and
the joint effect of two drugs (change rate of group A: 52.51±12.51%; group B: 54.78±11.27%; group C: 30.51±10.59%; group D:
91.75±21.43%;P<0.05) was studied. The much decreased platelet aggregability after antiplatelet therapy was evidence of the potential benefit
of the treatment in preventing thromboembolism after ablation. Pretreatment with aspirin and ticlopidine together is a good
way to decrease palatelet aggregability after RFCA. 相似文献
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阿司匹林-β-环糊精包合物的制备工艺优选 总被引:1,自引:0,他引:1
目的寻找阿司匹林-β-环糊精包合物(ASP-β-CYD)的最佳制备工艺。方法以包合率、包合物收率为指标,采用正交实验法,初步研究饱和水溶液搅拌法、超声波法和研磨法包合阿司匹林的最佳工艺。结果饱和水溶液法制备包合物的最佳工艺为阿司匹林的质量与β-环糊精的质量的比为1:8、包合温度为50℃、包合时间为2h、干燥温度50℃。包合率可以达到79.61%,包合物收率为76.19%。超声波法的最佳包合条件为阿司匹林的质量与β-环糊精的质量的比为1:8、超声时间为40min、干燥温度为50℃。包合率可以达到73.18%,包合物收率为79.26%。研磨法的最佳包合条件为阿司匹林的质量与β-环糊精的质量的比为1:8、研磨时间为20min、干燥温度为60℃。包合率可以达到84.41%,包合物收率为74.35%。结论超声波法制备包合物得到的包合率、综合评价均比其他两种方法高。 相似文献
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The antiulcerogenic effects of the methanolic extract ofSolanum nigrum berries (SBE) on aspirin induced ulceration in rats with respect to antioxidant status in the gastric mucosa have been investigated.
Oxygen free radicals are considered to be important factors in the pathogenesis of gastric ulcer. The level of lipid peroxides,
which were elevated highly in rats with acute gastric mucosal injury was taken as an index of oxidative stress. The activities
of antioxidant defense enzymes were also decreased considerably by oral gastric administration of aspirin. The decreased levels
of antioxidant enzymes and increased mucosal injury were altered to near normal status upon pretreatment with (SBE) when compared
to the ulcer induced rats. The results indicate that (SBE) may exert its gastroprotective effect by a free radical scavenging
action. Our observations suggest that (SBE) may have considerable therapeutic potential in the treatment of gastric diseases. 相似文献
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Rashmi Raghuvanshi M. Chandra P. C. Misra M. K. Misra 《Indian journal of clinical biochemistry : IJCB》2005,20(1):26-29
Platelets play important role in precipitating ischaemic myocardial syndromes in many ways. One of the consequences of ischaemic
diseases is excessive generation of oxygen derived free radicals that have numerous pathophysiological consequences. Platelet
pro-oxidant enzyme, xanthine oxidase is one of the sources of generation of free radicals. In the present paper, we report
the effect of administration of vitamin E along with aspirin on the levels of platelet xanthine oxidase and extent of free
radical mediated damage in the patients reperfused after myocardial infarction.
Our findings show that administration of 400 mg. vitamin E for six days along with 80 mg. aspirin has an excellent anti-oxidant
effect as evidenced by reduced platelet xanthine oxidase activity and lowering of malondialdehdye (MDA) levels which is an
index of the extent of free radical mediated damage. 相似文献
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