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Munjal M. Acharya Surbhi H. Khamesra Surendra S. Katyare 《Indian journal of clinical biochemistry : IJCB》2005,20(1):56-60
The effect of picrotoxin-induced convulsions on lysosomal function in rat brain were evaluated by measuring the free as well
as total acid phosphatase, cathepsin D, acid ribonuclease (RNAse II) and acid deoxyribonuclease (DNAse II) activities. Following
picrotoxin treatment the free RNAse II activity increased whereas the total activities of practically all the other enzymes
decreased. Paradoxically, the cathepsin D activity, free as well the total was completely abolished. In case of all the enzymes
the ratio of Total activity/Free activity decreased indicating increased lysosomal membrane fragility which could lead to
process of neurodegeneration in the epileptic animals. 相似文献
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