Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

尝试合作化教学——学习《生物入侵者》的体会

文章对初二生物与语文新教材中的同一个教学内容——“生物入侵者”实施合作化教学。在整个教学中，三科教师之间、学生之间、师生之间进行了互动学习、多方交流、教学相长。     

合作学习法在高一女生仰卧起坐练习中的应用研究

采用合作练习法与一般常规练习法配组对比的教学实验设计，将合作学习的要素运用在高一女生的体育教学中，探讨其对学生之间互相合作、交往以及仰卧起坐练习的积极促进效果。研究结果显示，合作学习组在经过实验干预之后，仰卧起坐练习提高的幅度较对照组更大，两个组均数t检验达到了非常显著的差异水平。这表明按照合作学习方法要素安排的仰卧起坐练习效果好于一般常规的练习方法。     

基于本体构建的协同推荐研究

通过构建领域本体,利用用户兴趣与领域本体中概念的映射关系,构建用户兴趣本体,发掘用户兴趣模式。研究用户兴趣本体相似度的计算方法,并通过用户兴趣相似度进行垂直加权,通过时间新颖度进行水平加权,从而利用改进的加权关联规则挖掘算法对用户感兴趣的领域本体中的概念进行挖掘,实现面向内容的协同推荐。     

对民国档案文件级整理工作的思索

在建国后五十多年时间里，档案工作在民国档案整理工作中，遵循档案形成的客观规律，依据全宗原则、利用原基础原则，对全国民国档案进行了案卷级整理工作，逐步建立了包括全宗目录、案卷目录、人名目录、地名目录等在内的民国档案目录体系，部分档案馆还建立了馆藏民国档案案卷级机读目录数据库。不过，随着民国档案开放力度增大，对档案内容信息的揭示提出了更高的要求，原有的民国档案整理成果已难满足现有的民国档案工作需要，对民国档案信息作进一步开发，即开展民国档案件级整理工作已逐渐被提上议事日程，但这项工作对我们来说是崭新的，我们需要对其必要性、和案卷级整理工作的衔接、应结合档案馆数字化工作开展以及在整理人员启用上如何谋求社会力量的支援等等问题加以认真思索。     

大型公共图书馆与社区图书馆的合作

本文在明确大型公共图书馆与社区图书馆范畴的基础上，针对这两类图书馆合作建设的共赢效果，探讨了两者合作建设的三种形式，并提出合作建设需注意的问题。     

企业竞争情报系统中的跨界合作

从企业竞争情报系统的应用现状分析出发，指出企业竞争情报系统需要在多方协作的环境下才能真正有效发挥作用。提出由企业、竞争情报系统提供商、情报信息提供商、图书馆、顾问咨询公司、高校等联合建立企业竞争情报协作环境，描述该环境下竞争情报工作各环节的合作模式，并分析用于支撑跨界合作的CCIS软件系统的实现要求。     

电子资源发展与图书馆业务变革

电子资源的快速发展，促进了数字化和网络化，提高了图书馆信息服务能力。在电子资源建设过程中，产生了多种形式的信息资源共建共享联盟，上海教育网络图书馆是其中之一。这种适合中国国情的制度创新有利于中小型图书馆的数字化网络化建设，促进了图书馆的改革。     

美国图书馆超联盟的形成机制--非零和合作博弈

文章论述了美国图书馆超联盟的形成机制及其潜在的驱动力量。