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K. Goswami S. Ghosh M. Bandyopadhyay K. L. Mukherjee 《Indian journal of clinical biochemistry : IJCB》2005,20(2):192-194
Hyper-ferrous state is the result of multiple transfusions, whereby the iron excess in such conditions may be toxic to the
organism. Patients suffering from thalassemia receive multiple transfusions. In the eastern part of India, both β0-thalassemia and heterozygous Eβ-thalassemia occur. This paper expresses the hyper-ferrous state, leading to iron overload
in these two conditions and also reports the increased generation of free radicals, consequent to the iron overload. 相似文献
2.
Jeevan K. Shetty Mungli Prakash Mohammad S. Ibrahim 《Indian journal of clinical biochemistry : IJCB》2008,23(1):67-70
Free iron in serum has been found in several disease conditions including diabetes. In the present work, we studied the relationship
between free iron, fasting blood glucose (FBG) and glycated haemoglobin (HbA1c). Study was carried out on 50 type 2 diabetes cases under poor glycemic control associated with complications, 53 type 2
diabetes cases under good glycemic control and 40 healthy controls. We estimated free iron, both ferrous (Fe+2) and ferric (Fe+3) form, protein thiols, lipid hydroperoxides, FBG, HbA1c and serum ferritin levels in serum. There was a significant increase
in free iron in Fe+3 state (p <0.01), HbA1c (p<0.01), serum ferritin (p<0.01), lipid hydroperoxides (p<0.01) and significant decrease in protein thiols (<0.01) in diabetes
cases under poor glycemic control compared to diabetes cases under good glycemic control and healthy controls. Free iron correlated
positively with HbA1c (p<0.01). Poor glycemic control and increase in glycation of haemoglobin is contributing to the increase in free iron pool
which is known to increase oxidant generation. 相似文献
3.
Singh B Goswami B Gupta N Bajaj AD Mallika V 《Indian journal of clinical biochemistry : IJCB》2011,26(1):41-45
Preterm delivery is a major contributor for neonatal mortality. Intensive research is underway to establish a reliable biomarker
that can ascertain the risk of preterm delivery in pregnant women. The aim of our study was to evaluate the role of various
biochemical parameters as potential biomarker for risk assessment for preterm labor. Forty women presenting with preterm labor
and 40 women who delivered at term were included in the study. Parameters that were evaluated include corticotrophin (ACTH),
prolactin, thyroid stimulating hormone (TSH), ferritin and Alkaline Phosphatase (ALP). Serum ACTH, ferritin, ALP and Ferritin/Iron
ratio were significantly higher in the subjects who delivered prematurely as compared to the controls. Comparison of sensitivity,
specificity, likelihood ratio, positive and negative predictive values for different cut offs for ACTH, ferritin, ALP and
ferritin/iron ratio was carried out. Ferritin emerged as the best marker with area under curve of 0.96 as compared to 0.88
for ACTH, 0.825 for ALP and 0.735 for ferritin/iron ratio. Our study establishes the superiority of ferritin as a predictive
biomarker for preterm labor as compared to the rest of the parameters evaluated. 相似文献
4.
Benedicta D’Souza Sulekha Sinha Poornima Manjrekar Vivian D’Souza 《Indian journal of clinical biochemistry : IJCB》2013,28(3):309-310
High ferritin levels have been found to be associated with non infectious as well as infectious causes including tuberculosis. This is one case report of 41 year old male who presented with cough with expectoration. The patient had Multi drug resistant tuberculosis (MDRTB) and type 2 diabetes mellitus. The laboratory findings showed Iron 280 μg/dl, Total iron binding capacity (TIBC) 61 μg/dl, and ferritin 92,945 ng/ml which indicates that iron is an essential nutrient for the survival of the pathogen Mycobacterium tuberculosis. 相似文献
5.
Moushumi Lodh Binita Goswami Nikhil Gupta Surajeet K. Patra Alpana Saxena 《Indian journal of clinical biochemistry : IJCB》2012,27(4):410-413
Multiple myeloma is a disseminated malignancy of monoclonal plasma cells that accounts for 15 % of all hematological cancers. The present study was conducted to evaluate the role of inflammation and oxidant-antioxidant dynamics in the etiology of this disease. The study population comprised of 20 cases of multiple myeloma and 20 healthy controls. The parameters evaluated were serum malondialdehyde (MDA), superoxide dismutase (SOD) and ferritin levels. The serum MDA levels were 1.9 ± 0.96 nmol/ml in cases as compared to 0.98 ± 0.55 nmol/ml in the controls. Similarly, a statistically significant difference was noted in the SOD and ferritin levels between the cases and controls (93.2 ± 23.8 vs. 210.1 ± 190.5 U/ml and 285.8 ± 216.4 vs. 131.8 ± 30.1 ng/ml respectively). Our study highlights the imbalance in the oxidant-anti oxidant mechanism and the role of smoldering inflammation in the etiology of multiple myeloma. 相似文献
6.
Sandhya Mishra D. C. Sharma Praveen Sharma 《Indian journal of clinical biochemistry : IJCB》2004,19(1):71-75
The study includes 102 confirmed cases of carcinoma breast with and without metastasis and 25 healthy non-pregnant females.
They were evaluated for blood levels of Ferritin, GSH, LDH, ALP, GGT and Hb before and 21 days after mastectomy. A significant
increase (p<0.001) was observed in ferritin, LDH and GSH levels in cancer patients without metastasis in comparison to normal
control subjects. Patients with metastasis had further elevated (p<0.001) levels of Ferritin, ALP and GGT as compared to non-metastatic
patients. Mastectomy in both the cases i.e. with and without metastasis resulted in non-significant decrease in all the biochemical
parameters suggesting that longer follow up could confirm post surgery decrease in the biochemical parameters. The results
of the study suggest cost effective, usefulness of Ferritin, ALP, GGT and GSH/Hb ratio in differentiating breast cancer patients
with and without metastasis which can be assayed in smaller laboratories. 相似文献
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