Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

做好文稿的退修工作

为了确保科技信息准确，快速，广泛地传播，编辑在做文稿退修时须把握好以下几点：1）注意对文稿内容，结构及统计数据的审查与质疑。2）注意对文稿标准化的审查与修改，使题名，摘要，关键词，名词术语，计量单位等符合科技期刊的标准化规范化要求。3）尊重作者劳动，退修意见力求准确，全面，具体，要求明确，确保一次退修成功。     

Using Context Clue in Reading

The context of a word consists of the other words surrounding it and the situation in which it is used.When we come across a new word in our reading,instead of looking it up in a dictionary for its definition,we can guess its meaning from its context.     

关于转型期间重点高中办学模式的思考

当前，处于从应试教育向素质教育转型之中的重点高中要在未来保持强大的生命力，根本问题是要改革目前的办学现状，根据社会需求不断发展、更新办学模式。改革重点高中的办学模式须从以下几个方面努力：一、重点高中的办学思想应避免“民族中心倾向”、“固守教条倾向”；二、转型期间重点高中应正确认识与坚持全面发展的培养目标；三、重点高中应转型为示范性普通高中。     

对于建设长江三角洲体育圈的战略构想

从苏、浙、沪地理位置和经济、社会、体育的实际情况和发展趋势出发,对于建设长江三角洲体育圈的指导思想、基本框架等方面,提出了一些设想和建议。     

关于体育赛事风险管理要素的研究

运用献资料法分析了我国当前举办体育赛事亟需加强风险管理的需要，并系统地分析了体育赛事风险的特征、效应及类型，通过对体育赛事风险管理的主体、客体、目标和对策等要素的研究，探讨了举办体育赛事加强风险管理的对策。     

演讲要讲究"三美"

出色的演讲首先形象要美，这样才会给观众留下美好的第一印象．为演讲成功打下良好的基础。演讲本身就是语言的艺术，语言的优劣直接关系到演讲的成败．所以演讲者的语言一定要美，并且演讲者口齿要清楚．控制好发音．使之优美动听．铿锵有力。演讲不但要传播思想，而且还要给人一种美的享受，这就要求演讲者使用准确、协调、优美、灵活自如的态势语言．做到态势美。     

王丽萍竞走关键技术研究

采用高速摄影及影片解析法、摄像及录像解析法、比赛现场采样法、关键技术会诊法，对王丽萍竞走关键技术进行了综合研究。研究的创造点是：1)针对奥运会新设女子20km竞走项目，依据国际田联“竞走定义“的技术标准，规范了王丽萍关键技术模式；2)开发了王丽萍送髋幅度大的技术优点，在奥运会比赛中获得良好的应用效果。     

大学生篮球运动员自我暗示语体系的研究

运用走访法、问卷法、实验法和心理测试等方法,初步构建了大学生篮球运动员积极自我暗示语体系,即赛前、赛中和赛后积极自我暗示语共计25条,并对其使用效果进行评价,从整体来讲,使用积极自我暗示语对改善大学生篮球运动员的比赛情景的认知水平是有效的,并且效果有性别差异,有角色重要性差异。