Circulating peptide and steroid hormone levels in patients with breast cancer

Circulating levels of gonadotropins (FSH,LH), prolactin (PRL), estradiol and progesterone were measured by radioimmunoassay in the sera of 60 patients with histopathologically proven breast cancer. 30 patients belonged to the post and 30 to the premenopausal group. 30 healthy women, 15 each in the pre and post menopausal groups served as controls for the study. Prolactin was elevated in 33% and 26% of pre and post menopausal breast cancer patients respectively. Lower levels of estradiol and progesterone were observed during the luteal phase of the menstrual cycle in premenopausal breast cancer patients. Among postmenopausal patients with breast cancer, LH was elevated in 32%, FSH in 15% and estradiol in 30% of the patients studied.     

Antipsychotics-induced hyperprolactinemia and screening for macroprolactin

IntroductionHigh prolactin (PRL) concentrations are found in laboratory test results of patients on majority of antipsychotic drugs. Prevalence rates and degrees of severity of hyperprolactinemia (HPRL) based on PRL concentration may depend on the presence of macroprolactin in the serum. The aim of the study was to investigate the difference between PRL concentrations before and after precipitation of macroprolactin and to examine if there were any changes in the categorization of HPRL between samples prior and after precipitation.Materials and methodsTotal of 98 female patients (median age 33; range 19-47 years) diagnosed with a psychotic disorder, proscribed antipsychotic drugs, and with HPRL were included. Total PRL concentration and PRL concentration after macroprolactin precipitation with polyethylene glycol (postPEG-PRL) were determined by the chemiluminometric method on the Beckman Coulter Access2 analyser.ResultsTotal PRL concentrations (median 1471; IQC: 1064-2016 mlU/L) and postPEG-PRL concentrations (median 1453; IQC: 979-1955 mlU/L) were significantly correlated using intraclass correlation coefficient for single measurements (mean estimation 0.96; 95%CI 0.93-0.97) and average measurement (mean estimation 0.98; 95%CI 0.96-0.99), and all investigated female patient had HPRL according to PRL and postPEG-PRL concentration. The median PRL recovery following PEG precipitation was 95; IQC: 90-100%. There was substantial agreement (kappa test = 0.859, 95% CI: 0.764-0.953) between the categories of HPRL severity based on total PRL concentrations and postPEG-PRL concentrations.ConclusionThe study demonstrated that HPRL was present in all subjects using the reference interval for total PRL concentration and postPEG-PRL concentration with no significant impact of macroprolactin presence in the serum on the categorization of patients according to severity of HPRL.     

女性系统性红斑狼疮患者血清中催乳素水平的研究

用放免法检测了２４名系统性红斑狼疮（ＳＬＥ）妇女及２０名健康对照组血清中催乳素（ＰＲＬ）水平， ＳＬＥ者同时检测ＩｇＧ和ＩｇＭ，结果发现ＳＬＥ伴有高催乳素血症，并且高水平 ＰＲＬ与 ＩｇＧ和 ＩｇＭ呈正相关．提示 ＰＲＬ通过刺激免疫球蛋白的产生诱导 ＳＬＥ发病．     

浅谈两栖类的变态

某些动物在发育过程中具有幼虫期,幼虫转变为成体要经过变态,本文重点介绍了两栖类的变态。,     

高温环境不同湿度条件下急性运动对人体血清催乳素、生长激素和皮质醇的影响

目的:探讨高温环境不同湿度条件下一次急性大强度运动对机体应激程度的影响;方法:20名来自不同专项的(平均年龄21.7±1.13岁,平均训练年限3.9±0.87年)男性受试者随机分为暴露组和运动组,分别在33℃,相对湿度20%、40%、60%、80%环境下进行高温暴露和进行急性大强度力竭性运动.用ELISA法测定运动前、后血清催乳素(PRL)、生长激素(GH)、皮质醇(cortisol)的浓度;结果:运动后血清PRL相对湿度60%组明显高于相对湿度20%组(P＜0.01),运动后血清cortisol相对湿度80%组明显高于相对湿度20%组(P＜0.01),运动后血清PRL、GH和cortisol均显著性升高.暴露组除相对温度80%组暴露后血清cortisol明显低于暴露前,其他各组均无显著性差异;结论:血清PRL是高温环境下运动对机体刺激较为敏感的一个指标,它可以反映机体热应激程度的大小,血清PRL与体温呈非常显著性相关.在高温环境下随着相对湿度的增加,运动引起的神经内分泌变化呈增加趋势,相对高温环境下,不同湿度条件运动对机体的应激程度不同.