几种增进机能的非兴奋剂使用药物和疗法

提出了关于在体育运动中非兴奋剂使用药物和疗法的观点，介绍了人乳、人血丙种球蛋白、氨基酸，脂肪乳制剂，人参、干姜、当归，回龙汤，能量合剂，暗示疗法，生物全息诊疗法，人工月经周期疗法等增进机能的辅助性非兴奋剂使用药物和疗法。     

The effect of l-citrulline and watermelon juice supplementation on anaerobic and aerobic exercise performance

Citrulline has been proposed as an ergogenic aid, leading to an interest in watermelon given its high citrulline concentration. The aim of this study was to determine the effects of a single, pre-exercise dose of l-citrulline, watermelon juice, or a placebo on the total maximum number of repetitions completed over 5 sets, time to exhaustion, maximal oxygen consumption (VO₂max), anaerobic threshold, and flow-mediated vasodilation. A randomised double-blind within-participants study design was used to examine these effects among 22 participants (n = 11 males). Supplementation included either a 7.5% sucrose drink containing 6 g of l-citrulline, 710 mL of watermelon juice (~1.0 g citrulline), or a 7.5% sucrose placebo drink. Supplementation was administered 1 or 2 h before exercise testing to investigate a timing effect. There was no significant effect between the three supplements for the total number of repetitions, time to exhaustion, VO₂max, anaerobic threshold, or flow-mediated vasodilation. There was also no interaction observed relative to gender or supplement timing (P > 0.05). A single dose of l-citrulline or watermelon juice as a pre-exercise supplement appears to be ineffective in improving exercise performance; however, greater doses of l-citrulline have been shown to be safe and are currently left unexamined.     

Acute caffeine ingestion enhances strength performance and reduces perceived exertion and muscle pain perception during resistance exercise

Abstract

The efficacy of caffeine ingestion in enhancing aerobic performance is well established. However, despite suggestions that caffeine may enhance resistance exercise performance, research is equivocal on the effect of acute caffeine ingestion on resistance exercise performance. It has also been suggested that dampened perception of perceived exertion and pain perception might be an explanation for any possible enhancement of resistance exercise performance due to caffeine ingestion. Therefore, the aim of this study was to examine the acute effect of caffeine ingestion on repetitions to failure, rating of perceived exertion (RPE) and muscle pain perception during resistance exercise to failure. Eleven resistance trained individuals (9 males, 2 females, mean age±SD=26.4±6.4 years), took part in this double-blind, randomised cross-over experimental study whereby they ingested a caffeinated (5 mg kg^?1) or placebo solution 60 minutes before completing a bout of resistance exercise. Experimental conditions were separated by at least 48 hours. Resistance exercise sessions consisted of bench press, deadlift, prone row and back squat exercise to failure at an intensity of 60% 1 repetition maximum. Results indicated that participants completed significantly greater repetitions to failure, irrespective of exercise, in the presence of caffeine (p=0.0001). Mean±S.D of repetitions to failure was 19.6±3.7 and 18.5±4.1 in caffeine and placebo conditions, respectively. There were no differences in peak heart rate or peak blood lactate values across conditions (both p >0.05). RPE was significantly lower in the caffeine compared to the placebo condition (p=0.03) and was significantly higher during lower body exercises compared to upper body exercises irrespective of substance ingested (p=0.0001). For muscle pain perception, a significant condition by exercise interaction (p=0.027) revealed that muscle pain perception was lower in the caffeine condition, irrespective of exercise. With caffeine, pain perception was significantly higher in the deadlift and back squat compared to the bench press. However, with placebo, pain perception was significantly higher for the deadlift and back squat compared to the prone row only. Therefore, acute caffeine ingestion not only enhances resistance exercise performance to failure but also reduces perception of exertion and muscle pain.     

Caffeine supplementation and peak anaerobic power output

Abstract

The aim of this study was to investigate the effects of caffeine supplementation on peak anaerobic power output (W_max). Using a counterbalanced, randomised, double-blind, placebo-controlled design, 14 well-trained men completed three trials of a protocol consisting of a series of 6-s cycle ergometer sprints, separated by 5-min passive recovery periods. Sprints were performed at progressively increasing torque factors to determine the peak power/torque relationship and W_max. Apart from Trial 1 (familiarisation), participants ingested a capsule containing 5 mg·kg^?1 of caffeine or placebo, one hour before each trial. The effects of caffeine on blood lactate were investigated using capillary samples taken after each sprint. The torque factor which produced W_max was not significantly different (p ≥ 0.05) between the caffeine (1.15 ± 0.08 N·m·kg^?1) and placebo (1.13 ± 0.10 N·m·kg^?1) trials. There was, however, a significant effect (p < 0.05) of supplementation on W_max, with caffeine producing a higher value (1885 ± 303 W) than placebo (1835 ± 290 W). Analysis of the blood lactate data revealed a significant (p < 0.05) torque factor × supplement interaction with values being significantly higher from the sixth sprint (torque factor 1.0 N·m·kg^?1) onwards following caffeine supplementation. The results of this study confirm previous reports that caffeine supplementation significantly increases blood lactate and W_max. These findings may explain why the majority of previous studies, which have used fixed-torque factors of around 0.75 N·m·kg^?1 and thereby failing to elicit W_max, have failed to find an effect of caffeine on sprinting performance.     

Acute taurine supplementation enhances thermoregulation and endurance cycling performance in the heat

Abstract

This study investigated the effects of oral taurine supplementation on cycling time to exhaustion at a fixed-intensity and thermoregulation in the heat. In a double-blind, randomised crossover design, 11 healthy males participated in a time to exhaustion test in the heat (35°C, 40% RH), cycling at the power output associated with ventilatory threshold, 2?h after ingesting: Taurine (50?mg?kg^?1) or placebo (3?mg?kg^?1?maltodextrin). Core and mean skin temperature, mean sweat rate, heart rate, rating of perceived exertion (RPE), thermal comfort and thermal sensation were measured during exercise and blood lactate concentration (B[La]) was measured after exercise. Taurine supplementation increased time to exhaustion by 10% (25.16 min vs. 22.43 min, p?=?0.040), end sweat rate by 12.7% (687?nL?min^?1 vs. 600?nL?min^?1, p?=?0.034) and decreased B[La] by 16.5% (5.75?mmol?L^?1 vs. 6.85?mmol?L^?1, p?=?0.033). Core temperature was lower in the final 10% of the time to exhaustion (38.5°C vs. 38.1°C, p?=?0.049). Taurine supplementation increased time to exhaustion and local sweating, while decreasing RPE and core temperature in the later stages of exercise, as well as reducing post-exercise B[La]. This study provides the evidence of taurine's role in thermoregulatory processes. These findings have implications for the short-term preparation strategies of individuals exercising in the heat. Based on these findings, a single dose of taurine 2?h prior to training or competition would provide an ergogenic and thermoregulatory effect.     

Effect of Caffeine Ingestion on Cardiorespiratory Endurance in Men and Women

Abstract

The effect of caffeine ingestion on submaximal endurance performance of 15 females and 13 males was investigated. After completing a [Vdot]O ₂ max test, each subject performed two submaximal cycling tests at approximately 75% of [Vdot]O ₂ max to exhaustion. For the caffeine (C) trials, 300 mg of caffeine was added to 250 ml of decaffeinated coffee and ingested one hour prior to the exercise. The decaffeinated (D) trial involved consuming 250 ml of decaffeinated coffee an hour prior to the test. The C and D trials were administered randomly using a standard double blind design. Physiological parameters were monitored each 9, 10, and 11 minute intervals throughout each trial and averaged. As expected the [Vdot]O ₂ (L · min ^?1 ), [Vdot]E and work outputs (kgm) were significantly (p < 0.001) higher for the males than the females. All other variables, time to exhaustion, [Vdot]O ₂ (ml · kg · min ^?1 ), R, HR, and rating of perceived exertion (RPE) were not significantly (p > 0.05) different between the sexes for either the C or D trials. Time to exhaustion was 14.4 and 3.1% longer for the C trials for the females and males, respectively, however these increases were not significant (p > 0.05). Furthermore, there were no significant differences (p > 0.05) for any of the measured variables during successive 10 minute work intervals between the C and D trials for either sex. These results do not support the general use of caffeine in moderate amounts as an ergogenic aid for either males or females, but from a practical point it appears that caffeine may have an ergogenic effect on specific individuals.     

Effects of short-term Rhodiola Rosea (Golden Root Extract) supplementation on anaerobic exercise performance

The purpose of this study was to examine the effects of short-term Rhodiola Rosea (Golden Root Extract (GRE)) supplementation on repeated Wingate performance. Eleven physically active college aged females were recruited for this study. In a within groups counterbalanced study design, participants were supplemented with either 1,500 mg/day of GRE or placebo (gluten-free cornstarch) for 3 days. Participants also took an additional 500 mg dose of corresponding treatment 30 minutes prior to testing of each trial. During each exercise trial, participants completed 3 × 15-second Wingate Anaerobic Tests (WAnTs) separated by 2-minute active recovery periods. Each exercise trial was separated by a 7 day washout period. Over the 3 × 15-second WAnTs, mean watts (p = 0.017, ES = 0.55), mean anaerobic capacity (p = 0.025, ES = 0.96), mean anaerobic power (p = 0.03, ES = 1.07), mean peak watts (p = 0.029,ES = 0.46), and mean total work (p = 0.017, ES = 0.49) were higher in the GRE treatment trial versus placebo. However, mean fatigue index (p = 0.094, ES = 0.39) was unaffected regardless of treatment. Our results show that GRE supplementation enhanced anaerobic exercise performance as measured through repeated WAnTs. GRE may possess ergogenic benefits and findings hold important implications for boosting anaerobic performance in repeated anaerobic bouts of exercise.     

Effects of caffeine chewing gum on race performance and physiology in male and female cyclists

This investigation reports the effects of chewing caffeinated gum on race performance with trained cyclists. Twenty competitive cyclists completed two 30-km time trials that included a maximal effort 0.2-km sprint each 10-km. Caffeine (~3–4 mg · kg^?1) or placebo was administered double-blind via chewing gum at the 10-km point following completion of the first sprint. Measures of power output, oxygen uptake, heart rate, lactate and perceived exertion were taken at set intervals during the time trial. Results indicated no substantial differences in any measured variables between caffeine and placebo conditions during the first 20-km of the time trial. Caffeine gum did however lead to substantial enhancements (mean ± 90% confidence limits (CLs)) in mean power during the final 10-km (3.8% ± 2.3%), and sprint power at 30-km (4.0% ± 3.6%). The increases in performance over the final 10-km were associated with small increases in heart rate and blood lactate (effect size of 0.24 and 0.28, respectively). There were large inter-individual variations in the response to caffeine, and apparent gender related differences in sprint performance. Chewing caffeine gum improves mean and sprint performance power in the final 10-km of a 30-km time trial in male and female cyclists most likely through an increase in nervous system activation.     

Effects of sodium phosphate and caffeine loading on repeated-sprint ability

The effects of sodium phosphate and caffeine supplementation were assessed on repeated-sprint ability. Using a randomised, double-blind, Latin-square design, 12 female, team-sport players participated in four trials: (1) sodium phosphate and caffeine, (2) sodium phosphate and placebo (for caffeine), (3) caffeine and placebo (for sodium phosphate) and (4) placebo (for sodium phosphate and caffeine), with ~21 days separating each trial. After each trial, participants performed a simulated team-game circuit (4 × 15 min quarters) with 6 × 20-m repeated-sprints performed once before (Set 1), at half-time (Set 2), and after end (Set 3). Total sprint times were faster after sodium phosphate and caffeine supplementation compared with placebo (Set 1: P = 0.003; Set 2: d = ?0.51; Set 3: P < 0.001; overall: P = 0.020), caffeine (Set 3: P = 0.004; overall: P = 0.033) and sodium phosphate (Set 3: d = ?0.67). Furthermore, total sprint times were faster after sodium phosphate supplementation compared with placebo (Set 1: d = ?0.52; Set 3: d = ?0.58). Best sprint results were faster after sodium phosphate and caffeine supplementation compared with placebo (Set 3: P = 0.007, d = ?0.90) and caffeine (Set 3: P = 0.024, d = ?0.73). Best sprint times were also faster after sodium phosphate supplementation compared with placebo (d = ?0.54 to ?0.61 for all sets). Sodium phosphate and combined sodium phosphate and caffeine loading improved repeated-sprint ability.     

Sports Nutriology-a Rapidly Developing New Branch of Learning

讨论了运动营养概念及其意义，指出运动营养学当前所面临的主要任务是研究：1）人体在运动时热能消耗量代谢规律，特点及需要量；2）人体三大热源物（蛋白质，脂肪糖）在运动时的代谢规律及与运动能力的关系；3）水、无机盐与运动能力的关系；4）维生素与运动能力；5）微量元素与运动能力；6）运动强力手段。