Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

我国中小学体育教师继续教育的优化与整合

采用文献法、问卷调查法、专家谈访法、比较分析法、层次分析法,在总结我国中小学体育教师继续教育主要特征的基础上,就中小学体育教师继续教育的优化与整合,对全国7省市582名中小学体育教师进行了调查研究.结果表明:构建中小学体育教师教育一体化的机构和师资队伍是提高中小学体育教师继续教育质量的组织保证;根据中小学体育教师成长的阶段性特征和价值取向,优化继续教育的组织模式、教学模式、教育内容是提高继续教育质量的关键.     

齐海峰竞技成绩的灰色关联分析及GM(1,N)动态协调模型的研究

采用文献资料法和灰色关联度分析法,对我国优秀男子十项全能运动员齐海峰1999-2002年十项全能的比赛成绩进行统计与分析,运用GM(1,N)动态协调模型对其在总成绩不断提高的各个阶段诸因素间相互联系、相互影响的辩证发展关系进行多方位、多层次研究。结果表明:100米跑、铅球和跳远是影响齐海峰专项成绩的关键因素,其关联度分别为0.8928、0.7443和0.7571,研究还发现,齐海峰在成绩提高的每一个阶段中,系统处于不稳定和非协调发展,其中速度和速度——力量性项目落后是导致系统不稳定和非协调发展的主要因素。     

二次曲线的三种分类方法分析

分析了二次曲线在仿射几何、射影几何和欧氏几何中的分类方法，给出了3种方法之间的联系与区别。     

试论田径技术课多媒体优化组合教学的特点

21世纪是科技信息迅猛发展的世纪,教育现代化,将引发传统教育发生全方位的变革,使传统的教育观念、内容、方法、手段及其结构向全新的现代化教育理论体系转变,同时形成新的教育模式.本文通过研究高师体育院系田径技术课多媒体优化组合教学的特点,以促进教学改革深入开展.     

首尾和r-循环矩阵的逆与广义逆的快速算法

利用多项式的快速算法,给出了求首尾和r-循环矩阵的逆、{1,2}———逆、Drain逆的快速算法.     

高校大规模排考系统的算法统计

It is a multifactor optimization problem to arrange examinations on a large scale for universities. In this paper, a kind of grouped optimization algorithm was proposed. A principle about related degree, which plays a core role in realization, was introduced in the algorithm. According to the algorithm, we worked out a set of software correspondingly and applied it to a certain university in Shanghai to arrange examinations. It shows that the algorithm is very effective.     

优秀运动员齐海峰竞技成绩的灰色关联分析及其模式训练研究

运用文献资料法和数理统计分析方法，对我国优秀男子十项全能运动齐海峰近几年的比赛成绩进行了综合分析，找出了影响其专项成绩的主要因素，并在此基础上，运用CM（1，N）动态协调模型对其在总成绩不断提高的过程中，系统处于不稳定和非协调发展局势，进行了多方位，多层次的研究，旨在对其成绩的提高起到借鉴作用。     

丁胱亚磺酰亚胺排空组织谷胱甘肽对大鼠心肌c-jun、c-fos mRNA的影响

设计三种实验模型,即力竭游泳运动模型、递增负荷游泳训练模型、BSO排空GSH模型,研究三种模型对大鼠心肌中原癌基因c-jun和c-fos mRNA表达的影响。结果发现力竭运动后训练力竭组、注射BSO力竭组、对照力竭组的大鼠心肌中c-jun mRNA表达量与相对应的训练安静组、注射BSO、对照安静组均增加,大鼠心肌中c-fos安静组mRNA表达量增加。BSO力竭组的c-fos mRNA表达量高于对照力竭组。训练力竭组与对照力竭组相比c-fos mRNA表达量没有明显变化。由上述实验结果推出,长时间力竭运动机体活性氧产生增加,c-jun mRNA和c-fos mRNA的表达量增加,进而激活转录因子AP-1。