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<正>当细胞接受到生理或病理信号时,会做出相应的反应从而最大可能地维护生命体的正常功能。细胞死亡是这类反应中的一个,它的调控在个体发育及维护生命个体正常功能上起着很大的作用。因此,细胞死亡的机制是现代生物学的一个研究热点。细胞的死亡可以以不同的方式进行。细胞的死亡方式不同往往会导致不同的生物学效应。厦门大学韩家淮实验室近期的工作发现细胞的死亡方式之间可以转换,而此转换受能量代谢调控的影响。 相似文献
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<正>类比推理是科学研究中常用的方法之一。如萨顿将看不见的基因与看得见的染色体的行为进行类比,根据两者惊人的一致性,提出了基因位于染色体上的假说。在日常教学过程中,我体会到类比推理不仅是一种研究方法,更可作为一种教学技巧。如果将一些学生熟知的生活实例与相对复杂的生物学概念或过程进行类比,可使学生很快理解复杂问题的本质,进而提高了课堂质效。本文就列举了一些我个人原创且教学效果不错的具体实例,供同行们斧正。 相似文献
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Proapoptotic and pronecrosis effect of different truncated hepatitis C virus core proteins 总被引:2,自引:0,他引:2
Yan XB Chen Z Luo DH Xu XY Wu W Zhou LF 《Journal of Zhejiang University. Science. B》2005,6(4):295-300
Objective: To study the roles of different truncated hepatitis C virus (HCV) core proteins (CORE) in the pathogenesis of HCV persistent infection and hepatocellular carcinoma (HCC) and to assess intracellular localization in transiently transfected cells. Methods: Seven truncated CORE-GFP (green fluorescent protein) fusion protein expression plasmids were constructed,which contained HCV CORE sequences derived from tumor tissues (BT) and non-tumor tissues (BNT) from one patient infected with HCV. Amino acid (aa) lengths were BT: 1-172 aa, 1-126 aa, 1-58 aa, 59-126 aa, 127-172 aa; BNT: 1-172 aa and C191:1-172 aa respectively. Subcellular localization of CORE-GFP was analyzed by con-focal laser scanning microscope. Apoptosis and necrosis were quantified by flow cytometry. Results: Different truncated CORE-GFP localized mainly in the cytoplasm, but nuclear staining was also observed. HCV CORE could induce apoptosis and necrosis, and different truncated COREs could induce cell apoptosis and necrosis at different levels. Among the same length 1-172 aa of BT, BNT and C191, the cell apoptosis and necrosis percentage of BT is highest, and C191 is the lowest (BT>BNT>C191). To the different fragment COREs of BT,N-terminal of CORE induced apoptosis and necrosis higher, compared with that of C-terminal (1-172 aa>1-126 aa>1-58aa> 127-172 aa>59-126 aa). Conclusion: These results suggest HCV CORE could induce apoptosis and necrosis of cells, which might play an important role in the pathogenesis of HCV persistent infection and HCC and the different CORE domains of different HCV quasi-species might have some difference in their pathogenesis. 相似文献
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细胞凋亡是由基因调控的细胞死亡过程,它对于多细胞生物的生存和发展以及维持其自身的稳定有极其重要的作用。通过查阅资料,对各种实验模型中运动或类似运动而引起的细胞凋亡进行总结,试图从中发现运动性疲劳与细胞凋亡的关系,以便为运动性疲劳的判断和恢复、运动损伤的尽快修复提供一定的指导。 相似文献
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本文以图、文方式剖析了人教版<分子与细胞>教材中的胞间连丝、协助扩散、无丝分裂和细胞坏死等知识点,便于学生进一步了解相关内容. 相似文献