单核细胞增多性李斯特菌RsbR抗酸应激机制（英文）

目的:探明单增李斯特菌RsbR的两个保守磷酸化位点是否影响SigB(sigmaB)的表达.创新点:解析了RsbR在单增李斯特菌中SigB网络调控中的作用.方法:通过基因缺失、定点突变和回补技术构建rsbR基因缺失株、回补株和回补突变菌株,进行酸应激条件下的生长能力和强酸条件下的存活能力试验,并检测在酸应激下菌株中的SigB基因和蛋白表达的改变情况.结论:RsbR缺失能够显著降低单增李斯特菌的抗酸应激能力和下调SigB表达,RsbR-175位点是SigB调控途径中RsbT释放的先决条件.     

Evaluation of Sigma-Metric and Application of Quality Tools in Clinical Laboratory of a Tertiary Care Hospital

Variability in analytical performance of some analyte indicated the need of evaluation of quality plan of our laboratory. We tried to put the same degree of effort into our quality metrics as we put into the laboratory processes themselves. Application of six sigma methodologies improve the quality by focusing on the root causes of the problems in performance and analyzing by flowcharts, fishbone diagrams and other quality tools. Sigma metric was calculated for laboratory parameters for a period of 8 months during 2018–19. The analytes with poor sigma metric were free Thyroxine (FT3, FT4), Sodium, Calcium and Magnesium. Sigma metric of free Thyroxine (FT3, FT4), Sodium, Calcium and Magnesium were below 3. A road map for process improvement was designed with DMAIC (Define-Measure-Analyze-Improve-Control) model to solve the issue. Possible causes for low analytical performance of the particular analytes were depicted in Fishbone diagram. The Fishbone analysis identified the water quality issues with electrolyte analysis while high ambient temperature was culprit for poor assay performance of free Thyroxine. Sigma metric of the analytical performance was assessed once again after root cause analysis. Sigmametric showed marked improvement in control phase. Identification of problems led to reduction in non value added work leading to adequate resource utilization by addressing the priority issue. Therefore, DMAIC tool with Fish bone model analysis can be recommended as a well suited method for troubleshooting in poor performance of laboratory parameter.     

精益六西格玛应用于高职教学质量提升的研究

将精益化和六西格玛有机融合并创建其理论架构,灵活应用和移植六西格玛改进（DMAIC）、精益化（Lean）和PDCA循环等重要方法,致力于构建高职院校DMAIC网络测评平台、精益化课程实施环节和 PDCA 闭环教学监控网络,形成综合系统的精益六西格玛教学质量管理体系,以期有效促进高职院校教学质量的提升。     

Teaching Lean Six Sigma within A Supply Chain Context: The Airplane Supply Chain Simulation

Lean six sigma is a management methodology that firms can employ to achieve substantial improvement in supply chain performance. However, few pedagogical exercises facilitate students’ use of a comprehensive set of lean six sigma principles within a supply chain context. We describe the Airplane Supply Chain Simulation that helps students understand how lean six sigma concepts may be leveraged to improve supply chain performance. The basis of this simulation is a four‐tier supply chain, consisting of suppliers (two tiers), a manufacturer, and a customer, that produces three models of paper airplanes to meet randomly distributed customer demand. In the first of three successive runs, a highly structured simulation is executed in which supply chain roles are well defined, material flows are convoluted, and a “push” production strategy is followed. The first simulation as the “current state” and, for the second and third simulation runs, challenge competing student teams to leverage lean six sigma concepts to develop a “future state” that enables the fulfillment of all customer orders at the lowest cost. Results based on statistical analyses of survey response data from 194 MBA students show that the Airplane Supply Chain Simulation is an effective participative, team‐based learning tool.     

基于6Sigma的采购质量改进方法及案例分析

企业在全球供应链管理环境下,加强采购质量管理已成为企业不可忽视的重要措施。6Sigma被引入企业采购质量管理能有效的提高顾客满意度,同时降低经营成本和周期。文章结合6Sigma管理法分析制药企业采购业务流程,定义采购缺陷,评估采购业务绩效,设定质量改进目标并提出相应改进措施,以期提高采购质量水平。     

应用Six-Sigma改进冷凝器焊接过程质量

针对ZY企业出现冷凝器焊接线缺陷率居高不下的问题,运用六西格玛管理改进型DMAICY模型(项目界定(D)、项目测量(M)、项目分析(A)、项目改进(I)、项目控制(C)、项目收益（Y）)进行质量业绩改进,使用Minitab软件对质量数据统计分析,并制定一套行之有效的改进方案;通过案例实施,焊接直通率由原来的91.4%上升到99.77%,六西格玛水平由1.33提升到2.84,工序能力明显增强,实证表明DMAICY模型在焊线质量改进中的成功应用实现了预期目标,产生了显著的经济收益。     

Interlibrary Loan Meets Six Sigma: The University of Arizona Library's Success Applying Process Improvement

In 2004, the University of Arizona Library Document Delivery Team embarked on a strategic project to assess the service quality and cost of filling interlibrary loan journal article borrowing requests. The Document Delivery Team utilized a Six Sigma Define, Measure, Analyze, Improve, and Control process improvement method. Improvements that were implemented as a result of this study led to increased satisfaction, decreased turnaround time, and lower cost per delivered article. Customer satisfaction surveys were utilized to discover customer expectations and requirements and to evaluate the effect of improvements on the customer experience. Measurement of internal business processes and cost analysis tools were used to determine cost savings.     

六西格玛在加油站计量管理中的应用与研究

本文对六西格玛在计量管理中的应用作了一次非常有益的尝试,实践证明六西格玛指标应用于计量考核是对传统计量合格率的突破,有着显著的经济效益,并突现了管理的科学性。经过提炼和规范可方便地在基层推广,值得一试。     

基于TQM的中小企业六西格玛管理研究

六西格玛管理作为目前企业界广泛关注的一种先进的管理方法,在国内外很多大型企业已经得到了成功的应用。而中小企业作为国民经济的重要组成部分也需要通过六西格玛管理来提升企业自身的产品质量,提高企业效益,增强中小企业市场竞争力。在分析六西格玛管理内涵的基础上,针对中小企业自身的特点,分析其实施六西格玛管理的优势和劣势,揭示了中小企业要推行实施六西格玛管理的必要条件,并在此基础上建立全面质量管理基础上的六西格玛管理体系模型。最后提出在实施过程中应注意的几点内容。     

综合录井随钻地层压力监测技术的应用

本文以丰富的现场资料和实践经验,阐述了西部钻探现场常规采用DC指数和sigma指数监测地层压力的难点,并通过实例分析、研究得到了相应的解决方法。为西部综合录井准确监测地层压力提供新方法和科学依据。