Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

对山西省知识分子体育消费频率、项目与动机调查

对山西省知识分子体育消费频率、项目与动机进行调查。调查表明 :山西省知识分子群体体育消费总体消费水平频率较低 ;消费项目以“观看比赛”和“购买服装”消费为主 ;体育消费以追求体育最基本的生物功能为主。     

论中法交涉宗藩权与保护权之争的实质

中法越南问题交涉 ,宗藩权和保护权之争一直是双方交涉的焦点。中国维护宗藩权 ,是维系中越历史久长的藩属关系 ,从而保护西南边陲的安全 ,遏制法势力渗入云贵 ;法国强加越南于保护权 ,目的是使越南脱离中国的藩属 ,使越沦为法殖民地 ,从而以越为基地侵夺中国的云贵。中法宗藩权与保护权之争是反殖民化与殖民化之争 ;是中越人民反侵略与法国侵略的斗争。尽管越南最终沦为法国殖民地 ,但中国援越抗法斗争的正义性是永存的     

网络传播媒介对当代美术批评方法论的拓展

从建构传统美术批评体系中的批评家与批评话语权之间的关系入手,就当下社会生活中的网络传播媒介对传统美术批评体系的解构现象进行了初步探讨,并从网络美术批评语言的重构、批评话语权的平民化方式、批评的学理完整性和依据以及批评的思维方式等方面对当代美术批评方法论的拓展进行了思考性阐述。     

英、美、中三国公民权利比较研究

权利是历史地形成并向前发展的。同样,历史也形成了英国、美国和中国等国的宪法规定的公民权利的内容和特点,也决定了他们不同的公民权利实现途径。对不同国家的公民权利进行比较,可以从比较中发现不足,取人所长,为我所用。这对发展我国的公民权利,完善我国的公民权利实现的机制具有重要的意义。     

试论我国职业足球联赛比赛质量的改进

1问题的提出足球比赛质量是提高足球观赏性，增加联赛上座率的一个重要因素。但目前国内学术界对有关比赛质量的研究成果还很少。本文通过对高质量足球比赛的特性、影响我国足球比赛质量的因素、如何改进足球比赛质量等问题的研究，旨在促进我国职业足球联赛的比赛质量能够满足     

知识经济背景下科技期刊的变革与编辑的转型

论述知识经济时代科技期刊及其生存空间的变革，为适应这种变革，科技期刊编辑应尽快转型，包括思想观念的转型，知识结构的转型，编辑职能和工作方式的转型，以及编辑社会角色的转型。     

信息资源有效配置中帕累托最优理论的适用性问题

由于知识产权制度 ,信息产品成为无形财产被纳入现实经济运行体系 ,因此 ,帕累托最优可以用于信息配置效率分析 ,建立具有实证意义和规范意义的标准。参考文献 5。     

Pupil participation: the NASEN policy

NASEN is to be congratulated for developing a Policy on Pupil Participation (NASEN, 2004). The importance of developing this practice has been increasingly recognised over recent years by policy makers, practitioners and researchers. In this short article I shall address some of the issues that the development of such a policy raises. Although generally welcoming NASEN's initiatives and similar actions by other organizations, I consider it important also to review the issue more broadly.