Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.     

Digital Module 05: Diagnostic Measurement—The G‐DINA Framework https://ncme.elevate.commpartners.com

In this ITEMS module, we introduce the generalized deterministic inputs, noisy “and” gate (G‐DINA) model, which is a general framework for specifying, estimating, and evaluating a wide variety of cognitive diagnosis models. The module contains a nontechnical introduction to diagnostic measurement, an introductory overview of the G‐DINA model, as well as common special cases, and a review of model‐data fit evaluation practices within this framework. We use the flexible GDINA R package, which is available for free within the R environment and provides a user‐friendly graphical interface in addition to the code‐driven layer. The digital module also contains videos of worked examples, solutions to data activity questions, curated resources, a glossary, and quizzes with diagnostic feedback.     

中药组方对提高有氧耐力运动员成绩的作用

把运动性疲劳的机体视为微细损伤的集合体,据此认识进行中药组方.通过对20名耐力跑运动员进行3个月分组对照实验后,测定实验前后的血色素(Hb)、个体乳酸阈值的跑速、红细胞(RBC)-SOD活性、RBC-GSH-Px活性、血浆丙二醛(MDA)的含量、RBC-MDA含量、定量负荷后血乳酸恢复速率和5000m跑最好成绩变化等.结果显示:服用中药组的各项指标和运动成绩均明显优于对照组(P＜0.05),表明本中药组方具有保护组织细胞、延迟疲劳出现和加快机能恢复的效果,对提高耐力运动成绩有良好的作用.     

中药复方制剂对力竭性游泳运动后大鼠骨骼肌线粒体的电镜观察

为了研究中药复方制剂对骨骼肌恢复的影响,采用组织学手段,通过电镜观察,研究中药复方制剂对力竭性运动大鼠骨骼肌的超微结构影响,结果发现服用中药复方制剂可以减少运动后线粒体形态结构的变化,改善大鼠骨骼肌线粒体机能,这对机体骨骼肌机能的恢复具有一定的帮助。     

循证医学和医学论文中统计学问题编辑鉴定的必要性

介绍循证医学这一新兴学说及其对21世纪临床医学的影响，指出为适应这一转变，开展医学论言语中统计学问题的编辑鉴定研究的必要性，开展此项研究可以：1）普及医学统计知识，2）提高临床与科研水平，3）提高作者撰写与阅读能力，4）提高医学期刊质量，5）丰富编辑学研究的内涵，并指出了编辑鉴审研究的初步思路。     

运动生理标准化考核对促进学生认知过程作用的初探

文章将标准化考试与传统考试方法作了对比分析．并将运动生理学第一次考试实施作了较全面的回顾，以及标准化考试对学生认知学习过程的促进作用．     

中西医结合治疗腰椎间盘突出症的研究

采用休息制动、手法按摩、牵引、骶管注射等中西医结合的保守疗法，对94例腰椎间盘突出症患者进行治疗，效果良好。     

中药消除运动性疲劳方法的研究综述

关于中药消除运动性疲劳的研究,近几年来取得很大的进展.但在今后一段时期还仍是运动医学界的重要话题.通过对近20年来部分研究文献的总结发现,运用中药消除运动性疲劳的方法主要有中药内服、中药外用、中药注射以及内外兼用四种.主要对这四种方法的研究及其临床实验进行了综述.     

行为医学与武术运动健身功能的内在一致性

武术是一种特殊的民族文化形态,具有健身、技击、以及观赏的社会价值。行为医学作为医学的三大体系之一,所整合的内容非常广阔,是一门综合性知识极强的体系。武术的健身功能与行为医学有着内在一致性,从行为医学的角度探讨了武术运动的健身功能。     

有氧健身操对中年女性心肺功能的影响

通过对60名中年女性实施16周有氧健身操练习，探讨有氧健身操对提高中年女性心肺功能的作用，结果发现有氧健身操可降低安静心率与血压、提高台阶实验指数、增加肺活量，是一种有效提高中年女性心肺功能的健身方法。